scholarly journals High Levels of Copper, Zinc, Iron and Magnesium, but not Calcium, in the Cerebrospinal Fluid of Patients with Fahr’s Disease

2010 ◽  
Vol 2 (2) ◽  
pp. 46-51 ◽  
Author(s):  
Isao Hozumi ◽  
Akihiro Kohmura ◽  
Akio Kimura ◽  
Tatsuya Hasegawa ◽  
Akiko Honda ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Fahr’S Disease ◽  
Fahr's Disease ◽  
Copper Zinc

scholarly journals A Case of Fahr's Disease Presenting as Chorea Successfully Treated by the Use of Quetiapine

2009 ◽  
Vol 2 ◽  
pp. CCRep.S3423
Author(s):  
Syoichiro Kono ◽  
Yasuhiro Manabe ◽  
Tomotaka Tanaka ◽  
Daiki Fujii ◽  
Yasuko Sakai ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cerebrospinal Fluid ◽  
Lactic Acid ◽  
White Matter ◽  
Calcium Phosphate ◽  
Subcortical White Matter ◽  
Laboratory Studies ◽  
Brain Computed Tomography ◽  
Fahr’S Disease ◽  
Fahr's Disease

We report a case of 30-year-old man presenting chorea in his legs. A brain computed tomography (CT) scan showed bilateral symmetric calcifications in the basal ganglia, thalamus, cerebellum and subcortical white matter. Laboratory studies showed no abnormalities of serum calcium, phosphate, PTH, lactic acid, pyruvic acid and cerebrospinal fluid. Under the diagnosis of Fahr's disease (FD), we treated with quetiapine (75 mg/day), which completely abolished his symptoms and he showed no other side effect. Our experience suggests that quetiapine is well tolerated in FD patients and effectively treats chorea without extrapyramidal movement.

Elevated cerebrospinal fluid lactate levels and the pathomechanism of calcification in Fahr's disease

2006 ◽  
Vol 13 (5) ◽  
pp. 539-543 ◽  
Author(s):  
N. Hagiwara ◽  
H. Ooboshi ◽  
M. Ishibashi ◽  
H. Kurushima ◽  
T. Kitazono ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Fahr’S Disease ◽  
Fahr's Disease ◽  
Lactate Levels

Fahr’s disease with an initial presentation of crescendo TIA

2021 ◽  
Vol 14 (6) ◽  
pp. e242837
Author(s):  
Paul Smith ◽  
Kalun Ng ◽  
Kailash Krishnan
Keyword(s):  
White Matter ◽  
Psychiatric Symptoms ◽  
Symptomatic Relief ◽  
Management Strategies ◽  
Initial Presentation ◽  
Fahr’S Disease ◽  
Fahr's Disease ◽  
Personality Changes ◽  
Brain Calcification ◽  
Ischaemic Attack

A 51-year-old man presented with vertigo, slurred speech and left facial droop. He had been previously diagnosed with transient ischaemic attack (TIA) and had a prior lacunar infarct. Imaging showed heavy symmetrical calcification in the globus pallidus, frontal white matter and cerebellar dentate nuclei/deep white matter. The imaging was pathognomonic for Fahr’s disease and diagnosis was confirmed when other secondary causes of hypercalcemia were excluded. Fahr’s disease is a rare, autosomal dominant, neurological condition characterised by primary brain calcification. Patients present with progressive neurological and psychiatric symptoms; commonly, Parkinsonian movement disorders, seizures, headaches, dysarthria, cognitive decline, psychosis and personality changes. There is an association with intracerebral ischaemic events. This case supports a growing body of anecdotal evidence of this association and is the first in which crescendo TIA may be the initial presentation of Fahr’s disease. Referral for genetic counselling and symptomatic relief for neurological symptoms are the main management strategies.

scholarly journals Fahr's disease: a rare neurological presentation in a tropical setting

2015 ◽  
Vol 3 (10) ◽  
pp. 806-808
Author(s):  
Akaninyene Asuquo Otu ◽  
Jude Chinedu Anikwe ◽  
Derek Cocker
Keyword(s):  
Fahr’S Disease ◽  
Fahr's Disease ◽  
Neurological Presentation

scholarly journals Adult-Onset Focal Chorea in Fahr's Disease Resulting FromSLC20A2Mutation: A Novel Phenotype

2014 ◽  
Vol 2 (1) ◽  
pp. 79-80 ◽  
Author(s):  
Miryam Carecchio ◽  
Chiara Barzaghi ◽  
Claudia Varrasi ◽  
Roberto Cantello ◽  
Barbara Garavaglia
Keyword(s):  
Adult Onset ◽  
Fahr’S Disease ◽  
Fahr's Disease

scholarly journals Fahr’s Disease Presenting as Bipolar Affective Disorder - Case Report

2017 ◽  
Vol 03 (01) ◽  
Author(s):  
Vutova V ◽  
Popov L ◽  
Zlatareva D ◽  
Tacheva S ◽  
Vladimirova R ◽  
...  
Keyword(s):  
Case Report ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Fahr’S Disease ◽  
Fahr's Disease

scholarly journals Fahr’s syndrome in adolescence: a case report

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Karla Costa ◽  
Jamson Nunes Junior ◽  
Guilherme Giunzioni ◽  
Maria de Fatima Rizzo ◽  
Gabriela Paladini
Keyword(s):  
Autosomal Dominant ◽  
Age Group ◽  
Pediatric Age ◽  
Fahr’S Disease ◽  
Pediatric Age Group ◽  
Incurable Disease ◽  
Fahr's Disease ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Irreversible Evolution

We present here a case of Fahr’s disease in the pediatric age group. Fahr’s disease is a neurological, degenerative and rare disease, especially in this age group. It differs from Fahrs syndrome, which is associated with infectious pathologies, such as human immunodeficiency virus infection and metabolic causes, such as hypoparathyroidism. In contrast, Fahr’s disease has an idiopathic or familial cause and is related to neuropsychic symptoms. However, the differentiation of these terms is still poorly established in the literature. It has an unknown prevalence and affects individuals of both sexes in any age group, and individuals from the 4th decade are more likely to develop it. It has polygenic etiology being autosomal dominant, characterized by abnormal deposits of minerals, including mainly calcium and phosphate in the basal ganglia. It presents extra-pyramidal, psychiatric and epileptic manifestations. It is an incurable disease with progressive and irreversible evolution. Due to the involvement of the central nervous system, the prognosis is reserved and eventually fatal. The patient in question was MF, 15-years-old, male, with severe holocranial headache and convulsive crisis with findings of calcifications in the base ganglia bilaterally tomography of the skull.

Sign in / Sign up

Export Citation Format

Share Document