scholarly journals Oxidized Low-Density Lipoprotein Induces Apoptosis in Endothelial Progenitor Cells by Inactivating the Phosphoinositide 3-Kinase/Akt Pathway

2010 ◽  
Vol 47 (6) ◽  
pp. 519-530 ◽  
Author(s):  
Guodong Tie ◽  
Jinglian Yan ◽  
Yagai Yang ◽  
Brian D. Park ◽  
Julia A. Messina ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Akt Pathway ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Endothelial Progenitor ◽  
Phosphoinositide 3 Kinase

scholarly journals The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0123971 ◽  
Author(s):  
Feng-Yen Lin ◽  
Nai-Wen Tsao ◽  
Chun-Ming Shih ◽  
Yi-Wen Lin ◽  
Jong-Shiua Yeh ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Endothelial Progenitor

Carbamylated low‐density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells

2011 ◽  
Vol 25 (4) ◽  
pp. 1314-1322 ◽  
Author(s):  
Julia Carracedo ◽  
Ana Merino ◽  
Carolina Briceño ◽  
Sagrario Soriano ◽  
Paula Buendía ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Endothelial Progenitor ◽  
Accelerated Senescence

scholarly journals Probucol Protects Endothelial Progenitor Cells Against Oxidized Low-Density Lipoprotein via Suppression of Reactive Oxygen Species Formation In Vivo

2016 ◽  
Vol 39 (1) ◽  
pp. 89-101 ◽  
Author(s):  
Qingbin Zhang ◽  
Liming Chen ◽  
Zhihua Si ◽  
Haoran Bu ◽  
Chandrakala A. Narasimhulu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Ros Production ◽  
Oxygen Species ◽  
Oxidized Low Density Lipoprotein

Background/Aims: Oxidized low-density lipoprotein (ox-LDL) is a major component of hyperlipidemia and contributes to atherosclerosis. Endothelial progenitor cells (EPCs) play an important role in preventing atherosclerosis and notably decreased in hyperlipidemia. Ox-LDL and ox-LDL-related reactive oxygen species (ROS) have deleterious effects on EPCs. Probucol as an antioxidant and anti-inflammatory drug reduces ROS production. The present study was to determine if probucol could protect EPCs from ox-LDL in vivo and to investigate the potential mechanisms. Methods: ox-LDL was injected into male C57BL/6 mice for 3 days with or without probucol treatment with PBS as control. Bone marrow (BM) fluid, serum, circulating mononuclear cells (MNCs) and EPCs were collected for analysis. Results: the increased extracellular ROS in BM, serum and blood intracellular ROS production in the mice with ox-LDL treatment in association with a significant reduction of circulating MNCs and EPCs were restored with Probucol treatment. A significant increase in the serum ox-LDL and C-reactive protein and decrease in superoxide dismutase and circulating MNCs and EPCs were observed in hyperlipidemic patients that were effectively reversed with probucol treatment. Conclusion: these data suggested that probucol could protect EPCs from ox-LDL through inhibition of ROS production in vivo.

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