Local Delivery of Angiotensin II Receptor Blockers into the Kidney Passively Attenuates Inflammatory Reactions during the Early Phases of Streptozotocin-Induced Diabetic Nephropathy through Inhibition of Calpain Activity

2010 ◽  
Vol 115 (3) ◽  
pp. e69-e79 ◽  
Author(s):  
Fadia Kamal ◽  
Nadezhda Yanakieva-Georgieva ◽  
Honglan Piao ◽  
Tetsuo Morioka ◽  
Takashi Oite
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Local Delivery ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Calpain Activity ◽  
Inflammatory Reactions ◽  
Receptor Blockers ◽  
Early Phases

Underuse of ACE inhibitors and angiotensin II receptor blockers among patients with diabetic nephropathy in Taiwan

Health Policy ◽  
2011 ◽  
Vol 100 (2-3) ◽  
pp. 196-202 ◽  
Author(s):  
Hseng-Long Yeh ◽  
Li-Ying Huang ◽  
Syi Su ◽  
Ming-Chin Yang ◽  
Ting-Chung Wang
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Ace Inhibitors ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Receptor Blockers

scholarly journals Renoprotective Effects of Various Angiotensin II Receptor Blockers in Patients with Early-Stage Diabetic Nephropathy

2010 ◽  
Vol 33 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Nobuharu Fujiwara ◽  
Eiichi Sato ◽  
Yoshihiko Ueda ◽  
Takeshi Sugaya ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Early Stage ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Receptor Blockers

scholarly journals Identification of the Stages of Diabetic Nephropathy at Which Angiotensin II Receptor Blockers Most Effectively Suppress Albuminuria

2013 ◽  
Vol 26 (9) ◽  
pp. 1064-1069 ◽  
Author(s):  
Susumu Ogawa ◽  
Masato Matsushima ◽  
Takefumi Mori ◽  
Masashi Okamura ◽  
Miho Senda ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Receptor Blockers

The Impact of Angiotensin-II Receptor Blockers on Cardiovascular Events in Hypertensive Patients – Evidence from Real-life Databases

2010 ◽  
Vol 6 (3) ◽  
pp. 33
Author(s):  
Robert J Petrella ◽  
Keyword(s):  
Angiotensin Ii ◽  
Antihypertensive Drugs ◽  
Real Life ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Real World Setting ◽  
Actual Experience ◽  
Receptor Blockers ◽  
Randomised Controlled ◽  
The Impact

It is widely recognised that hypertension is a major risk factor for the development of future cardiovascular (CV) events, which in turn are a major cause of morbidity and mortality. Blood pressure (BP) control with antihypertensive drugs has been shown to reduce the risk of CV events. Angiotensin-II receptor blockers (ARBs) are one such class of antihypertensive drugs and randomised controlled trials (RCTs) have shown ARB-based therapies to have effective BP-lowering properties. However, data obtained under these tightly controlled settings do not necessarily reflect actual experience in clinical practice. Real-life databases may offer alternative information that reflects an uncontrolled real-world setting and complements and expands on the findings of clinical trials. Recent analyses of practice-based real-life databases have shown ARB-based therapies to be associated with better persistence and adherence rates and with superior BP control than non-ARB-based therapies. Analyses of real-life databases also suggest that ARB-based therapies may be associated with a lower risk of CV events than other antihypertensive-drug-based therapies.

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