Low-Dose Valganciclovir as Preemptive Therapy for Cytomegalovirus Infection Occurring in Allogeneic Stem Cell Transplant Recipients

2010 ◽  
Vol 123 (4) ◽  
pp. 230-234 ◽  
Author(s):  
Mariangela Palladino ◽  
Luca Laurenti ◽  
Patrizia Chiusolo ◽  
Paola Piccioni ◽  
Idanna Innocenti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cytomegalovirus Infection ◽  
Low Dose ◽  
Stem Cell Transplant ◽  
Preemptive Therapy ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients

Preemptive Therapy for Cytomegalovirus Disease in Allogeneic Stem Cell Transplant Recipients

2008 ◽  
Vol 40 (9) ◽  
pp. 3102-3103 ◽  
Author(s):  
F. de la Cruz-Vicente ◽  
P. Cerezuela Martinez ◽  
E. Gil-Espárraga ◽  
C. Martin Aguilera ◽  
M. Aguilar Guisado ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplant ◽  
Preemptive Therapy ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients ◽  
Cytomegalovirus Disease

scholarly journals Lack of Emergence of Cytomegalovirus UL97 Mutations Conferring Ganciclovir (GCV) Resistance following Preemptive GCV Therapy in Allogeneic Stem Cell Transplant Recipients

2001 ◽  
Vol 45 (12) ◽  
pp. 3669-3671 ◽  
Author(s):  
C. Gilbert ◽  
J. Roy ◽  
R. Belanger ◽  
R. Delage ◽  
C. Beliveau ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplant ◽  
Preemptive Therapy ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients ◽  
Pp65 Antigenemia ◽  
Therapy Trial ◽  
Ganciclovir Resistance

ABSTRACT Fifty allogeneic stem cell transplant recipients were enrolled in a prospective cytomegalovirus pp65 antigenemia-guided preemptive therapy trial. Among these, 10 of 34 patients who received ganciclovir exhibited sustained and/or recurrent antigenemia despite treatment. Thirteen leukocyte preparations from these 10 subjects were screened for the presence of the most frequent cytomegalovirus UL97 mutations conferring ganciclovir resistance. None of these mutations were detected after mean and median ganciclovir exposures of 31.6 and 28.0 days, respectively.

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