The Cellular Basis of Immunologic Memory

1971 ◽  
pp. 223-267 ◽  
Author(s):  
F. Celada
Keyword(s):  
Immunologic Memory ◽  
Cellular Basis

Cellular Basis for Immunologic Memory

Nature ◽  
1971 ◽  
Vol 232 (5313) ◽  
pp. 639-641 ◽  
Author(s):  
R. K. GERSHON ◽  
J. KRÜGER ◽  
J. D. NAYSMITH ◽  
B. H. WAKSMAN
Keyword(s):  
Immunologic Memory ◽  
Cellular Basis

scholarly journals Metabolic Swifts Govern Normal and Malignant B Cell Lymphopoiesis

2021 ◽  
Vol 22 (15) ◽  
pp. 8269
Author(s):  
Aikaterini Poulaki ◽  
Stavroula Giannouli
Keyword(s):  
B Cell ◽  
B Lymphocytes ◽  
Control Program ◽  
Memory B Cells ◽  
Immunologic Memory ◽  
Human Immune System ◽  
B Cell Malignancies ◽  
Stringent Control ◽  
Human Immune ◽  
New Research

B lymphocytes are an indispensable part of the human immune system. They are the effective mediators of adaptive immunity and memory. To accomplish specificity against an antigen, and to establish the related immunologic memory, B cells differentiate through a complicated and strenuous training program that is characterized by multiple drastic genomic modifications. In order to avoid malignant transformation, these events are tightly regulated by multiple checkpoints, the vast majority of them involving bioenergetic alterations. Despite this stringent control program, B cell malignancies are amongst the top ten most common worldwide. In an effort to better understand malignant pathobiology, in this review, we summarize the metabolic swifts that govern normal B cell lymphopoiesis. We also review the existent knowledge regarding malignant metabolism as a means to unravel new research goals and/or therapeutic targets.

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