Role of Th2 Cells in IgG4-Related Lacrimal Gland Enlargement

2010 ◽  
Vol 152 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Hiroko Kanari ◽  
Shin-ichiro Kagami ◽  
Daisuke Kashiwakuma ◽  
Yoshihiro Oya ◽  
Shunsuke Furuta ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Th2 Cells ◽  
Gland Enlargement

The role of TH1 and TH2 cells in a rodent malaria infection

Science ◽  
1993 ◽  
Vol 260 (5116) ◽  
pp. 1931-1934 ◽  
Author(s):  
A. Taylor-Robinson ◽  
R. Phillips ◽  
A Severn ◽  
S Moncada ◽  
F. Liew
Keyword(s):  
Malaria Infection ◽  
Th2 Cells ◽  
Rodent Malaria ◽  
Th1 And Th2

Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease

2018 ◽  
Vol 257 (2) ◽  
pp. 405-411 ◽  
Author(s):  
Eri Ishikawa ◽  
Yasuhiro Takahashi ◽  
Ma. Regina Paula Valencia ◽  
Marian Grace Ana-Magadia ◽  
Hirohiko Kakizaki
Keyword(s):  
Lacrimal Gland ◽  
Thyroid Eye Disease ◽  
Eye Disease ◽  
Gland Enlargement

scholarly journals Potential of Immunoglobulin A to Prevent Allergic Asthma

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Anouk K. Gloudemans ◽  
Bart N. Lambrecht ◽  
Hermelijn H. Smits
Keyword(s):  
Allergic Asthma ◽  
Immunoglobulin A ◽  
Bronchial Hyperresponsiveness ◽  
Airway Disease ◽  
Epidemiological Studies ◽  
Allergic Airway Disease ◽  
Secretory Iga ◽  
Th2 Cells ◽  
Lower Airway

Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens. The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma. In contrast, in healthy individuals, allergen-specific IgA and IgG4 molecules are found but no IgE, and their T cells fail to proliferate in response to allergens, probably because of the development of regulatory processes that actively suppress responses to allergens. The presence of allergen-specific secretory IgA has drawn little attention so far, although a few epidemiological studies point at a reverse association between IgA levels and the incidence of allergic airway disease. This review highlights the latest literature on the role of mucosal IgA in protection against allergic airway disease, the mechanisms described to induce secretory IgA, and the role of (mucosal) dendritic cells in this process. Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies.

Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses toAspergillus fumigatus

2002 ◽  
Vol 283 (1) ◽  
pp. L198-L204 ◽  
Author(s):  
Jane M. Schuh ◽  
Kate Blease ◽  
Steven L. Kunkel ◽  
Cory M. Hogaboam
Keyword(s):  
T Cell ◽  
Airway Hyperresponsiveness ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Th2 Cells ◽  
Wild Type ◽  
Cell Recruitment ◽  
Chronic Model ◽  
Airway Responses

Eotaxin/CCL11 is a major chemoattractant for eosinophils and Th2 cells. As such, it represents an attractive target in the treatment of allergic disease. The present study addresses the role of eotaxin/CCL11 during acute and chronic allergic airway responses to the fungus Aspergillus fumigatus. Mice lacking the eotaxin gene (Eo−/−) and wild-type mice (Eo+/+) were sensitized to A. fumigatus and received either an intratracheal challenge with soluble A. fumigatusantigens (acute model) or an intratracheal challenge with live A. fumigatus spores or conidia (chronic model). Airway hyperresponsiveness and eosinophil, but not T cell, recruitment were significantly decreased at 24 h after the soluble allergen in A. fumigatus-sensitized Eo−/− mice compared with similarly sensitized Eo+/+ mice. In contrast, the development of chronic allergic airway disease due to A. fumigatus conidia was not altered by the lack of eotaxin. Together, these data suggest that eotaxin initiates allergic airway disease due to A. fumigatus, but this chemokine did not appear to contribute to the maintenance of A. fumigatus-induced allergic airway disease.

scholarly journals Abstract 2679: Role of TH2 cells in pancreatic cancer progression

2021 ◽  
Author(s):  
Aftab Alam ◽  
Maulasri Bhatta ◽  
Parker Denz ◽  
Eric Levanduski ◽  
Prasenjit Dey
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Th2 Cells

Lacrimal Gland Enlargement

2014 ◽  
pp. 69-69
Author(s):  
Om Sharma ◽  
Violeta Mihailovic-Vucinic
Keyword(s):  
Lacrimal Gland ◽  
Gland Enlargement
Sign in / Sign up

Export Citation Format

Share Document