Retinal Early Receptor Potential in Retinitis pigmentosa: Correlations with Visual Field and Fluoroangiography Estimates

1991 ◽  
Vol 203 (2) ◽  
pp. 82-88 ◽  
Author(s):  
Mauro Fioretto ◽  
Raffaella Lotti ◽  
Stefania Rela ◽  
Gian Piero Fava ◽  
Walter G. Sannita
Keyword(s):  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Receptor Potential ◽  
Early Receptor Potential

scholarly journals Concentric division of 10° visual field tests in retinitis pigmentosa

2013 ◽  
Vol 57 (3) ◽  
pp. 268-274 ◽  
Author(s):  
Ken Ogino ◽  
Atsushi Otani ◽  
Akio Oishi ◽  
Masafumi Kurimoto ◽  
Takuro Sekiya ◽  
...  
Keyword(s):  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Field Tests

scholarly journals A novel mutation in the PRPH2 gene in a Chinese pedigree with retinitis pigmentosa and angle-closure glaucoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei-ning Li ◽  
Xiu-juan Du ◽  
Yu-ting Zhang ◽  
Le-yi Wang ◽  
Jing Zhu
Keyword(s):  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Novel Mutation ◽  
Genetic Mutation ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
The Novel ◽  
Progressive Loss ◽  
Whole Exome ◽  
Transversion Mutation

Abstract Background Retinitis pigmentosa (RP) is a rare, progressive, and hereditary disorder that leads to the progressive loss of vision and visual field, and in some cases blindness. The specific relationship between RP and glaucoma has been debated for decades. Methods In this study, we examined a Han RP family with concomitant angle-closure glaucoma (ACG), performed an inductive analysis of their clinical features and assistant results, and applied whole-exome sequencing (WES) technology for a molecular diagnosis. Results A novel transversion mutation (c.626 T > A) was identified in the peripherin-2 (PRPH2) gene in the proband, resulting in the substitution of Valine to aspartic acid in codon 209. A full ophthalmic examination showed that the proband with the c.626 T > A mutation had a typical RP manifestation, with close angles; however, the proband’s elder brother, who lacked the novel mutation, had a normal fundus and open angles. Conclusion Our results extend the genetic mutation spectrum of PRPH2 in RP, and provide evidence to support a genetic correlation between RP and ACG.

scholarly journals Electrophysiological measurement of the number of rhodopsin molecules in single Limulus photoreceptors.

1977 ◽  
Vol 70 (5) ◽  
pp. 621-633 ◽  
Author(s):  
J E Lisman ◽  
H Bering
Keyword(s):  
Relative Intensity ◽  
Surface Density ◽  
Receptor Potential ◽  
Absolute Intensity ◽  
Charge Movement ◽  
Half Time ◽  
Quantal Response ◽  
Early Receptor Potential ◽  
Electrophysiological Measurement ◽  
Electrophysiological Methods

Two partly independent electrophysiological methods are described for measuring the number of rhodopsin molecules (R) in single ventral photoreceptors. Method 1 is based on measurements of the relative intensity required to elicit a quantal response and the relative intensity required to half-saturate the early receptor potential (ERP). Method 2 is based on measurements of the absolute intensity required to elicit a quantal response. Both methods give values of R approximately equal to 10(9). From these and other measurements, estimates are derived for the surface density of rhodopsin (8,000/micrometer2), the charge movement during the ERP per isomerized rhodopsin (20 X 10(-21) C), and the half-time for thermal isomerization of rhodopsin (36yr).

scholarly journals A Prediction Method of Visual Field Sensitivity Using Fundus Autofluorescence Images in Patients With Retinitis Pigmentosa

2020 ◽  
Vol 61 (10) ◽  
pp. 51
Author(s):  
Tatsuya Inoue ◽  
Kosuke Nakajima ◽  
Yohei Hashimoto ◽  
Shotaro Asano ◽  
Kohdai Kitamoto ◽  
...  
Keyword(s):  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Fundus Autofluorescence ◽  
Prediction Method ◽  
Field Sensitivity

scholarly journals Effect of Short-Term Oral Valproic Acid on Vision and Visual Field in Retinitis Pigmentosa

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
P. Mahesh Shanmugam ◽  
C. K. Minija ◽  
Rajesh Ramanjulu ◽  
Pradeep Tekwani ◽  
Manish Saxena
Keyword(s):  
Valproic Acid ◽  
Visual Field ◽  
Retinitis Pigmentosa ◽  
Short Term
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