Gender Dimorphic Associations between N-Terminal Pro-Brain Natriuretic Peptide, Body Mass Index and Blood Pressure in Children and Adolescents

2010 ◽  
Vol 73 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Panagiota Pervanidou ◽  
Athanassios Akalestos ◽  
Sophia Sakka ◽  
Christina Kanaka-Gantenbein ◽  
Ioannis Papassotiriou ◽  
...  
2011 ◽  
Vol 15 (4) ◽  
pp. 477-484 ◽  
Author(s):  
Hernan TRIMARCHI ◽  
Alexis MURYAN ◽  
Mariana DICUGNO ◽  
Mariano FORRESTER ◽  
Fernando LOMBI ◽  
...  

Cardiology ◽  
2017 ◽  
Vol 137 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Zubair Shah ◽  
Mark Wiley ◽  
Arun Mahankali Sridhar ◽  
Reza Masoomi ◽  
Mazda Biria ◽  
...  

Objective: The aim of this paper was to study the association between body mass index (BMI) and coronary sinus (CS) brain natriuretic peptide (BNP) levels in patients with heart failure and reduced systolic function (HFrEF). Background: There is an inverse relationship between systemic venous BNP (V-BNP) levels and BMI in patients with HFrEF. It is unclear whether this finding is due to decreased production or due to an increased metabolism of BNP. Since CS-BNP levels reflect BNP production, we hypothesized that assessing the correlation of CS-BNP levels with BMI would provide insight into the mechanism of this inverse relationship of V-BNP and BMI. Methods: We prospectively enrolled 54 subjects with HFrEF who were to undergo cardiac resynchronization device implantation. CS-BNP, V-BNP, and arterial BNP (A-BNP) levels were measured during the implant procedure. Subjects were divided into 2 groups based on their BMI (group 1: BMI <30 and group 2: BMI ≥30). Results: The mean age of the overall study group was 64 ± 10 years. Average BMI for group 1 was 25.8 ± 2.8 and 36.8 ± 4.6 for group 2 (p < 0.03). A history of hypertension was present in 55% (n = 26) of the subjects, while diabetes was reported in 31% (n = 15). Serum creatinine was 1.0 ± 0.2 mg/dL and TSH 2.1 ± 1.4 mIU/L. 79% of the subjects were receiving β-blockers, while 94% were receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. The mean CS-BNP, V-BNP, and A-BNP levels in group 2 were significantly lower than in group 1 (286.2 ± 170.5 vs. 417.5 ± 247.5 pg/mL, p = 0.04; 126.6 ± 32.5 vs. 228 ± 96.4 pg/mL, p = 0.01; and 151.9 ± 28.6 vs. 242 ± 88.8 pg/mL, p = 0.04, respectively). Univariate analysis and multivariate regression adjusted for age, diabetes mellitus, sex, glomerular filtration rate, and left atrial size confirmed BMI as an independent predictor of CS-BNP levels (β = -0.372, p = 0. 03) in our study. Conclusions: In this study, we demonstrate an inverse relationship between CS-BNP levels and BMI in patients with HFrEF. These findings suggest that the previously established inverse relationship between V-BNP and BMI is due to a decreased cardiac production of BNP in obese patients rather than from increased peripheral metabolism.


2017 ◽  
Vol 27 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Shu-Rong Wang ◽  
Yong-Bao Zhu ◽  
Yan Cheng ◽  
Ying-Xiu Zhang

2011 ◽  
Vol 34 (8) ◽  
pp. 963-967 ◽  
Author(s):  
Romulo A Fernandes ◽  
Diego G D Christofaro ◽  
Camila Buonani ◽  
Henrique L Monteriro ◽  
Jefferson R Cardoso ◽  
...  

Author(s):  
Shahnaz Taghizadeh ◽  
Mahdieh Abbasalizad Farhangi ◽  
Fathollah Poorali

Introduction: The prevalence of childhood high blood pressure is rising fast. The possibility of high blood pressure augments with increasing body mass index (BMI), inappropriate dietary intake and lifestyle problems. The aim of this study was to investigate the correlation between blood pressure, body mass index, life style and dietary habits in children and adolescents aged 6 - 18 years in Tabriz, Iran. Methods: The present study was a cross-sectional study. Using data of the Sib software (the software used in the health transformation system) were collected. This data includes anthropometric information, some demographic factors, dietary intake and lifestyle of 425 children and adolescents with overweight and obesity. The data were analyzed by STATA software (MP 4.2 potable 2017). Results: The association between systolic blood pressure and dairy products (P = 0.02), watching TV / PC (P = 0.041), BMI quarter (P <0.001), BMI (P <0.001), and age (P <0.001) as well as the association between diastolic blood pressure with BMI quarter (P <0.001), BMI (P <0.001) and age (P <0.001) was statistically significant and the other variables did not show a meaningful statistical relationship. Conclusion: Age, BMI, less dairy consumption, and watching TV/PC has a relationship with high blood pressure. Therefore, nutritionists and health workers should consider the above considerations when making recommendations in children and adolescents with overweight and obesity.


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