Surgical Excision of Basal Cell Carcinoma with Complete Margin Control: Outcome at 5-Year Follow-Up

Dermatology ◽  
2010 ◽  
Vol 220 (4) ◽  
pp. 363-369 ◽  
Author(s):  
T. Wetzig ◽  
M. Woitek ◽  
K. Eichhorn ◽  
J.C. Simon ◽  
U. Paasch
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Surgical Excision ◽  
Margin Control

Staged excision of primary periocular basal cell carcinoma: absence of residual tumour in re-excised specimens: a 10-year series

2018 ◽  
Vol 103 (7) ◽  
pp. 976-979 ◽  
Author(s):  
Lindsay A McGrath ◽  
Adam Meeney ◽  
Zanna I Currie ◽  
Hardeep Singh Mudhar ◽  
Jennifer H Tan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Significant Proportion ◽  
Surgical Excision ◽  
Lower Eyelid ◽  
Growth Patterns ◽  
Residual Tumour ◽  
Tumour Characteristics

AimsThe aim is to study staged periocular basal cell carcinoma (BCC) excision in a tertiary oculoplastic referral centre in Sheffield, UK. In particular, we examined patients with close or positive margins and no tumour seen on re-excision to identify demographics and tumour characteristics in this population.MethodsA retrospective review of medical records of 437 cases of staged periocular BCC excisions over a 10-year period (2007–2017) was carried out. Patients had surgical excision with 3 mm clinically clear margins. Staged excision was performed for all cases included in this study. Standard reconstruction techniques were employed. Histopathology was analysed for tumour type, subtype and stage.ResultsOver the 10-year period, of the 437 periocular BCCs, 156 had close or involved margins. Residual tumour was found in 29 (18.6%), whereas in 122 eyelids of 120 patients (78.2%) no residual tumour was identified on histological examination. Micronodular (54.1%) and nodular (23.7%) growth patterns of BCC, as well as lower eyelid location (72.1%), were the most prevalent in this population. Two patients (1.6%) had recurrence of BCC over a mean follow-up of 57 months (range 1–125 months).ConclusionsA significant proportion of BCCs transected on initial excision show no residual tumour in the re-excision specimens. In the interval between initial excision and re-excision, there may be eradication of the residual tumour. The exact mechanisms for this are unclear, however, and re-excision remains the appropriate recommended course in the presence of involved surgical margins of periocular BCC, particularly when high-risk tumour subtypes are encountered.

scholarly journals Histological and Clinical Features of Primary and Recurrent Periocular Basal Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Guy J. Ben Simon ◽  
Semion Lukovetsky ◽  
Fabio Lavinsky ◽  
Nahum Rosen ◽  
Mordechai Rosner
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Clinical Characteristics ◽  
Frozen Section ◽  
Surgical Excision ◽  
Anatomical Location ◽  
Duration Of Symptoms ◽  
Histological Features ◽  
Margin Control

Background. Basal cell carcinoma (BCC) is the most common malignancy of the eyelids. Medial canthal BCCs tends to recur more often. Purpose. To evaluate the clinical and histological features of primary and recurrent periocular BCC, in order to identify any existing associations. Methods. Data from 87 patients (71 primary and 16 recurrent) were analyzed in this study. All patients underwent tumor excision with frozen section margin control at the Goldschleger Eye Institute between 1/1995 to 12/1997. Statistical analysis was performed to identify possible associations between histological and clinical characteristics of primary and recurrent BCC. Main Outcome Measures. Anatomical location, clinical presentation, and histology of peri-ocular BCC. Results. No association was found between histopathological and clinical characteristics of BCC. Similar features with regard to eyelid location and histology were found in primary and recurrent peri-ocular BCCs, whereas recurrent BCCs tended to involve a greater eyelid extent with a longer duration of symptoms. Medial canthal BCCs, morpheaform, or sclerosing histology were not more common in the recurrent BCC group. Conclusions. Similar clinical and histological characteristics were noted in primary and recurrent periocular BCC, implying that incomplete surgical excision rather than anatomical location or histological features is the main cause for recurrence.

Surgical excision versus Mohs’ micrographic surgery for basal cell carcinoma of the face: A randomised clinical trial with 10year follow-up

2014 ◽  
Vol 50 (17) ◽  
pp. 3011-3020 ◽  
Author(s):  
Eva van Loo ◽  
Klara Mosterd ◽  
Gertruud A.M. Krekels ◽  
Marieke H. Roozeboom ◽  
Judith U. Ostertag ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Surgical Excision ◽  
Randomised Clinical Trial ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
The Face

scholarly journals Ulcerated Metatypical Basal Cell Carcinoma of the Forehead

2017 ◽  
Vol 5 (6) ◽  
pp. 807-809
Author(s):  
Jose Cardoso ◽  
Uwe Wollina ◽  
Georgi Tchernev
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Disease ◽  
Basal Cell ◽  
Fusidic Acid ◽  
Aggressive Behaviour ◽  
Surgical Excision ◽  
Clinical Impression ◽  
Local Recurrences

An 81-year-old male presented with an ulcerated lesion on the frontal area. The lesion had started three years before with a small ulceration and was initially treated with a cream of betamethasone and fusidic acid twice daily for several months. The clinical impression was ulcerated basal cell carcinoma (BCC).The histopathological findings after surgical excision were consistent with metatypical or basosquamous carcinoma.  The importance of metatypical and basosquamous carcinomas is their potential for a more aggressive behaviour than conventional BCC, both regarding local recurrences and metastatic disease. Clinicians should be aware of the more aggressive behaviour of metatypical BCC since it may influence the protocols of follow-up of these patients to timely detect local recurrences and/or metastatic disease.

scholarly journals 490 5-Year Follow-up of Periocular Primary Basal Cell Carcinoma at Burnley General Teaching Hospital

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
Y Lu ◽  
H Usmani ◽  
B Fernando
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Recurrence Rate ◽  
Teaching Hospital ◽  
Basal Cell ◽  
Surgical Excision ◽  
Anatomical Site ◽  
Recommended Treatment ◽  
Standard Set

Abstract Aim (1) To investigate the recurrence rate of periocular primary basal cell carcinoma (pBCC) in Burnley General Teaching Hospital (BGTH). (2) To compare the recurrence rate of periocular pBCC in our centre with the standards published by the British Association of Dermatologists (BAD). Method A retrospective cohort study was carried out. Inclusion criterion was all patients undergoing surgical excision of periocular pBCC in BGTH between January 2011 to December 2016. Electronic records were reviewed, and the recurrence rate locally was then calculated and compared with the 2% stated in the BAD guidelines [1]. Results A total of 197 cases met the audit inclusion criteria over the period of 5 years at BGTH. All of them completed 5 years of follow-up. The mean age of the selected population was 75.7 years (SD 12.77). Male:female ratio was 104:93. Only one case was identified as recurrent primary BCC, which makes the recurrence rate of this audit 0.5% (1/197). Conclusions This audit confirmed that the recurrence rate of periocular pBCC after margin section control achieved the standard set by BAD guidelines. The reason might be that reconstruction is performed after the confirmation of marginal clearance. Although the recommended treatment for pBCC is MMS, it is not available in every centre. However, patients need to wait at least one week for the reconstruction after margin section control. The limitation of this audit includes the data of the size and anatomical site were incomplete for all patients due to inconsistent histology reports.

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