Heart Rate and Blood Pressure Response and Metabolic Changes in the Sheep Fetus following Reduction of Uterine Blood Flow

1983 ◽  
Vol 15 (5) ◽  
pp. 300-317 ◽  
Author(s):  
Wolfgang Künzel ◽  
Eckart Kastendieck ◽  
Manfred Hohmann
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Metabolic Changes ◽  
Uterine Blood Flow ◽  
Sheep Fetus

scholarly journals Large Conductance Ca2+-Activated and Voltage-Activated K+ Channels Contribute to the Rise and Maintenance of Estrogen-Induced Uterine Vasodilation and Maintenance of Blood Pressure

Endocrinology ◽  
2012 ◽  
Vol 153 (12) ◽  
pp. 6012-6020 ◽  
Author(s):  
Charles R. Rosenfeld ◽  
Timothy Roy
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Uterine Artery ◽  
K Channel ◽  
Uterine Blood Flow ◽  
K Channels ◽  
Channel Inhibition ◽  
Estradiol 17Β ◽  
Cgmp Synthesis

Abstract Uterine blood flow (UBF) increases greater than 4-fold 90 min after systemic estradiol-17β (E2β) in nonpregnant sheep and remains elevated longer than 6–8 h; mean arterial pressure (MAP) is unchanged. Large-conductance Ca+2-activated (BKCa) and voltage-activated (KV) K+ channels contribute to the acute rise in UBF; their role in maintaining UBF and MAP longer than 90 min is unknown. We examined this in five nonpregnant, ovariectomized ewes with uterine artery (UA) flow probes and catheters in a UA for infusion of K+ channel inhibitors and uterine vein to sample venous effluent. Animals received systemic E2β (1.0 μg/kg; control), E2β+UA tetraethylammonium (TEA; 0.4–0.8 mm, n = 4), and E2β+UA 4-aminopyridine (4-AP; 0.01–0.08 mm, n = 4) to block BKCa and KV, respectively, while monitoring MAP, heart rate, and UBF. Uterine cGMP synthesis was measured. Ninety minutes after E2β, UBF rose 4.5-fold, uterine vascular resistance (UVR) fell greater than 5-fold and MAP was unchanged [78 ± 0.8 (sem) vs. 77 ± 1.5 mm Hg] in control studies and before UA inhibition with TEA and 4-AP. Between 90 and 120min, UBF, UVR, and MAP were unchanged after E2β alone. E2β+TEA dose dependently decreased ipsilateral UBF and increased UVR (24 ± 8.9 and 38 ± 16%, respectively, at 0.8 mm; P < 0.03); MAP was unchanged. Contralateral UBF/UVR were unaffected. E2β+4-AP also dose dependently decreased ipsilateral UBF and increased UVR (27 ± 5.3 and 76 ± 18%, respectively, at 0.08 mm; P < 0.001); however, MAP rose 27 ± 6.9% (P ≤ 0.006). E2β increased uterine cGMP synthesis greater than 3.5-fold and was unaffected by local K+ channel inhibition. BKCa and KV contribute to the rise and maintenance of E2β-induced uterine vasodilation, which is partially cGMP dependent. Systemic vascular KV also contributes to maintaining MAP after systemic E2β.

scholarly journals Resistance exercise with different volumes: blood pressure response and forearm blood flow in the hypertensive elderly

2014 ◽  
pp. 2151 ◽  
Author(s):  
Caio Victor Coutinho de Oliveira ◽  
Amilton da Cruz Santos ◽  
Aline Brito ◽  
Maria so Socorro Brasileiro
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Resistance Exercise ◽  
Forearm Blood Flow ◽  
Blood Pressure Response ◽  
Pressure Response

scholarly journals Relationship between blood pressure response during hemodialysis and exercise tolerance or heart rate recovery measured using cardio-pulmonary exercise testing in maintenance hemodialysis patients

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Hiroki Yabe ◽  
Kenichi Kono ◽  
Ryota Shiraki ◽  
Akiho Masuda ◽  
Yoshifumi Moriyama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oxygen Uptake ◽  
Exercise Testing ◽  
Exercise Tolerance ◽  
Blood Pressure Response ◽  
Heart Rate Recovery ◽  
Cardiopulmonary Exercise Testing ◽  
Pressure Response ◽  
Exercise Intolerance

Abstract Background This study investigated the association between the blood pressure response during hemodialysis (HD) and exercise tolerance or heart rate recovery (HRR) measured with cardiopulmonary exercise testing (CPX). Methods The study enrolled 23 patients who had been undergoing 4-h regular maintenance HD. The maximum workload (Loadpeak), peak oxygen uptake (VO2peak), workload and oxygen uptake at the anaerobic threshold (LoadAT and VO2AT, respectively), and HRR were measured with CPX. The average systolic blood pressure during HD (SBPav) was measured, and the number of times the SBP was less than 100 mmHg was determined in the 2-week period after CPX. Results The SBPav showed a significant correlation with LoadAT (r = 0.46) and Loadpeak (r = 0.43, p < 0.05). The number of times the SBP was less than 100 mmHg showed a significant correlation with the HRR (r = − 0.44, p < 0.05). Conclusion Exercise intolerance and HRR in HD patients may be associated with blood pressure instability during HD.

scholarly journals Caffeine Consumption and Heart Rate and Blood Pressure Response to Regadenoson

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130487 ◽  
Author(s):  
Abbas Bitar ◽  
Ronald Mastouri ◽  
Rolf P. Kreutz
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Caffeine Consumption
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