Mass Treatment of Parasitic Disease: Implications for the Development and Spread of Anthelmintic Resistance

2010 ◽  
pp. 120-137 ◽  
Author(s):  
Thomas S. Churcher ◽  
Ray M. Kaplan ◽  
Bernadette F. Ardelli ◽  
Jan M. Schwenkenbecher ◽  
María-Gloria Basáñez ◽  
...  
Keyword(s):  
Anthelmintic Resistance ◽  
Parasitic Disease ◽  
Mass Treatment

scholarly journals Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis

2022 ◽  
Vol 15 (1) ◽  
pp. 80
Author(s):  
Ehab Ghazy ◽  
Mohamed Abdelsalam ◽  
Dina Robaa ◽  
Raymond J. Pierce ◽  
Wolfgang Sippl
Keyword(s):  
Life Cycle ◽  
Histone Deacetylase ◽  
Control Strategy ◽  
Histone Deacetylases ◽  
Drug Targets ◽  
Hdac Inhibitors ◽  
Parasitic Disease ◽  
Mass Treatment ◽  
Epigenetic Mechanisms ◽  
Histone Deacetylase 8

Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel. Schistosomes display morphologically distinct stages during their life cycle and the transformations between stages are controlled by epigenetic mechanisms. The targeting of epigenetic actors might therefore represent the parasites’ Achilles’ heel. Specifically, histone deacetylases have been recently characterized as drug targets for the treatment of schistosomiasis. This review focuses on the recent development of inhibitors for schistosome histone deacetylases. In particular, advances in the development of inhibitors of Schistosoma mansoni histone deacetylase 8 have indicated that targeting this enzyme is a promising approach for the treatment of this infection.

CPD article: Equine gastrointestinal parasite infections

UK-Vet Equine ◽  
2020 ◽  
Vol 4 (5) ◽  
pp. 156-160
Author(s):  
Ian Wright
Keyword(s):  
Anthelmintic Resistance ◽  
Gastrointestinal Parasites ◽  
Parasitic Disease ◽  
Gastrointestinal Parasite ◽  
Wide Range ◽  
Fundamental Understanding ◽  
Parasite Infections ◽  
Intestinal Worm ◽  
Worm Control

Horses can be infected by a wide range of gastrointestinal parasites including roundworms, tapeworms and bot flies. Anthelmintics have formed the basis of intestinal worm control in horses through routine use for many years but the development of anthelmintic resistance now means that strategies are required to limit anthelmintic use while minimising parasitic disease. Pasture and stable hygiene, accurate dosing of horses and faecal testing are all key to reducing anthelmintic use, while not compromising welfare. A fundamental understanding of the parasites involved and communication with clients is vital if these aims are to be achieved.

Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex

1974 ◽  
Vol 12 (2) ◽  
pp. 141 ◽  
Author(s):  
Han Jong Rim ◽  
Joung Hwan Ha ◽  
Joon Sang Lee ◽  
Il Hyun ◽  
Kwang Bon Uh
Keyword(s):  
Kainic Acid ◽  
Mass Treatment ◽  
Acid Complex

Effect of Jatropha curcas Latex on L3 Haemonchus contortus Larval Motility

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Noorzaid Muhamad ◽  
Syahirah Sazeli ◽  
Resni Mona ◽  
Jannathul Firdous
Keyword(s):  
Larvicidal Activity ◽  
Jatropha Curcas ◽  
Haemonchus Contortus ◽  
Anthelmintic Resistance ◽  
Small Ruminants ◽  
Gastrointestinal Nematodes ◽  
Dose Dependent ◽  
Plants Extract

The anthelmintic resistance has limited the control of gastrointestinal nematodes of small ruminants and thus has awakened interest in the study of plants extract as a source of anthelmintics. These experiments were carried out to evaluate the in vitro efficacy of Jatrophacurcas latex extract against Haemonchuscontortus larval motility. To evaluate the larvicidal activity, H.contortus L3 were incubated with the extracts with varying concentration of 5 mg/mL, 10 mg/mL, 15 mg/mL and 20 mg/mL at 27°C for 48, 72 and 96 hrs. The results were subjected to the Kruskal-Wallis test (P less than 0.05). The extracts showed dose-dependent larvicidal effects. These results suggest that J.curcas can be used to control gastrointestinal nematodes of small ruminants.

Reduce Disease Burden of Human Schistosomiasis in Asia Through Biological Control

2020 ◽  
Vol 20 (12) ◽  
pp. 1118-1132
Author(s):  
Sidra Saleem ◽  
Haroon Ahmed ◽  
Tooba Siddiqui ◽  
Seyma Gunyakti Kilinc ◽  
Aisha Khan ◽  
...  
Keyword(s):  
Biological Control ◽  
Geographical Distribution ◽  
Disease Burden ◽  
Management Practices ◽  
Control Strategies ◽  
Parasitic Disease ◽  
Asian Countries ◽  
Neglected Disease ◽  
Current Review ◽  
Near Future

Schistosomiasis is a chronic parasitic disease caused by a trematode blood fluke of the genus Schistosoma that belongs to the Schistosomatidae family. It is a neglected disease in different regions of Asia. In this review, 218 articles (between 2000 and 2017) related to the topic were collected from PubMed and Google scholar and reviewed. After thoroughly reading collected articles, due to irrelevant topic requirements, 94 articles were excluded. Articles that have data associated with Asian regions are considered. In Asia, the disease is prevalent in China, Philippines, Indonesia, Yemen, Nepal and Laos, etc. While in Pakistan, India and Bangladesh, the disease is not endemic and very few cases were reported. The disease was eliminated from Japan and Iran. The current review highlights the geographical distribution among Asian countries, transmission patterns, diagnosis, control strategies based on the use of anthelmintic plants and management practices implemented in Asia for the control of schistosomiasis. However, new implementations to treat schistosomiasis in humans should be proved to eliminate the disease finally in the future. This review emphasizes the biological control of schistosomiasis for the eradication of the disease from Asia in the near future.

scholarly journals Successful pregnancy after operation in an infertile woman caused by luteinizing hormone-secreting pituitary adenoma: case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi Zhang ◽  
Cheng Chen ◽  
Min Lin ◽  
Kan Deng ◽  
Huijuan Zhu ◽  
...  
Keyword(s):  
Case Report ◽  
Pituitary Adenoma ◽  
Literature Review ◽  
Pituitary Adenomas ◽  
Sella Turcica ◽  
Infertile Woman ◽  
Mass Treatment ◽  
Successful Pregnancy ◽  
Case Presentation ◽  
Transsphenoidal Resection

Abstract Background Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual. Case presentation A 30-year-old woman with elevated LH and normal FSH presented with inability to conceive. An MRI revealed an enlarged sella turcica and an intrasellar mass. Treatment with transsphenoidal resection led to normalization of LH and estradiol, as well as successful pregnancy. And we reviewed 6 cases of LH-secreting pituitary adenomas from 1981 to 2020. Conclusions Our case is unique because of the LH-secreting pituitary adenoma without FSH hypersecretion. This case indicates that pituitary adenoma should be considered when other diseases causing infertility have been excluded.

scholarly journals Ocular toxocariasis: a neglected parasitic disease in Egypt

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Nagwa Mostafa El-Sayed ◽  
Nagham Gamal Masoud
Keyword(s):  
Parasitic Disease ◽  
Ocular Toxocariasis
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