scholarly journals Power of Competing Strategies of Linkage Analysis for Complex Traits

2010 ◽  
Vol 70 (1) ◽  
pp. 55-62
Author(s):  
Jianzhong Ma ◽  
E. Warwick Daw ◽  
Christopher I. Amos
Keyword(s):  
Linkage Analysis ◽  
Complex Traits

scholarly journals Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent.

Genetics ◽  
1995 ◽  
Vol 140 (2) ◽  
pp. 843-856
Author(s):  
J Dupuis ◽  
P O Brown ◽  
D Siegmund
Keyword(s):  
Linkage Analysis ◽  
Statistical Methods ◽  
Complex Traits ◽  
Gene Interaction ◽  
Polymorphic Markers ◽  
Identity By Descent ◽  
Descent Data ◽  
Multilocus Model ◽  
Multiplicative Models ◽  
Dense Set

Abstract A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis). Statistical methods of linkage analysis are discussed under the assumption that identity by descent data from a dense set of polymorphic markers are available. Three methods, single locus search, simultaneous search and conditional search, are described and compared.

Two-locus approach of segregation and linkage analysis in the study of complex traits

1995 ◽  
Vol 12 (6) ◽  
pp. 825-830 ◽  
Author(s):  
Jianfeng Xu ◽  
Eugene W. Taylor ◽  
Carolien I. M. Panhuysen ◽  
Valerie L. Prenger ◽  
Rebecca Koskela ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Complex Traits
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