Amino Acid Control of Neurotransmitter Synthesis and Release: Physiological and Clinical Implications

1993 ◽  
Vol 60 (1) ◽  
pp. 18-32 ◽  
Author(s):  
Hendrik Lehnert ◽  
Richard J. Wurtma
Keyword(s):  
Amino Acid ◽  
Clinical Implications ◽  
Acid Control ◽  
Neurotransmitter Synthesis

scholarly journals Self-Dividing Micelles: A Mechanistic Look with Evolutionary and Clinical Implications

2021 ◽  
pp. 8-20
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Laboratory Testing ◽  
Prebiotic Chemistry ◽  
Clinical Implications ◽  
Proof Of Concept ◽  
Mass Spec ◽  
First Time ◽  
Division Mechanism ◽  
Viable Treatment

Micellar therapy has become a usefully viable treatment arm in various fields, ranging from oncology to bioimaging. As such, research leading to any improvements or adaptations in administration and techniques can have far-reaching consequences. Potential aspects of prebiotic chemistry may also be explored in such research as well. To that end, proof-of-concept experiments were performed to elucidate a possible mechanism of action for prebiotic protocell division. Representative potentially prebiotically plausible biomolecules, i.e., a fatty acid, amino acid, and nucleotide were mixed and heated in water and subjected to microscopic examination for observation of possible self-division and laboratory testing for the presence of polypeptides and polynucleotides (Biuret, MALDI mass-spec, etc.) with and without the presence of nucleotide. The results are presented for the first time here and a mechanism is proposed that best fits the data obtained. The evolutionary, e.g., prebiotic biomolecular cooperativity, and clinical, e.g., potential antineoplastic micellar/vesicular therapy, ramifications are discussed as well. Keywords: Micelle; Liposome; Protocell; MRNA; Self-division; Mechanism; Solid tumors

scholarly journals Structure of yeast regulatory geneLEU3and evidence thatLEU3itself is under general amino acid control

1987 ◽  
Vol 15 (13) ◽  
pp. 5261-5273 ◽  
Author(s):  
Kemin Zhou ◽  
Paula R.G. Brisco ◽  
Ari E. Hinkkanen ◽  
Gunter B. Kohlhaw
Keyword(s):  
Amino Acid ◽  
General Amino Acid Control ◽  
Acid Control

Optimum dietary amino acid pattern and limiting order of some essential amino acids for growing-furring blue foxes (Alopex lagopus)

2004 ◽  
Vol 78 (1) ◽  
pp. 77-86 ◽  
Author(s):  
T. Dahlman ◽  
J. Valaja ◽  
E. Venäläinen ◽  
T. Jalava ◽  
I. Pölönen
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Control Diet ◽  
Essential Amino Acids ◽  
Amino Acid Pattern ◽  
N Retention ◽  
Low Protein ◽  
Acid Control ◽  
Blue Fox ◽  
Limiting Amino Acid

AbstractThe optimum pattern and limiting order of some essential amino acids for growing-furring blue foxes were assessed from nitrogen (N) retention responses. Total tract digestibility and N balance trials were carried out on 24 weaned blue fox males in an 8 ✕ 5 cyclic change-over experiment. Eight experimental diets were prepared by removing proportionately about 0·4 of each of the amino acids studied – methionine + cystine, lysine, threonine, tryptophan and histidine – successively from the amino acid control diet. The main source of protein in the amino acid control diet was casein and an amino acid mixture was added to bring the calculated crude protein (CP) content up to the level of 170 g/kg dry matter (DM). Low-protein (CP 95·7 g/kg DM) and high-protein (CP 166·6 g/kg DM) diets, the protein proportion of which was casein protein, served as negative and positive control diets, respectively. The reduction in N retention when one amino acid in turn was deleted from the amino acid control diet was calculated, and a regression analysis was made between N retention and relative amino acid intake. Data on the animals’ intake of each limiting amino acid and those on the amino acid control diet were used. The optimum amino acid pattern, expressed relative to lysine = 100, proved to be: methionine + cystine 77, threonine 64, histidine 55 and tryptophan 22. The first-limiting amino acids were methionine + cystine. Blue fox responses (N retention, weight gain) to deletion of methionine + cystine from the diet were very severe and exceeded those to deletion of any other amino acid. Moreover, removing methionine + cystine from the diet significantly impaired the apparent digestibility of organic matter, reducing it to a level even lower than that of the low-protein diet. After methionine + cystine, the next-limiting amino acid in casein-based diets was threonine, followed by histidine and tryptophan. The results show the importance of verifying the sufficiency of dietary methionine + cystine in the practical feeding of blue foxes.

scholarly journals Boron Stress Activates the General Amino Acid Control Mechanism and Inhibits Protein Synthesis

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27772 ◽  
Author(s):  
Irem Uluisik ◽  
Alaattin Kaya ◽  
Dmitri E. Fomenko ◽  
Huseyin C. Karakaya ◽  
Bradley A. Carlson ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Amino Acid ◽  
Control Mechanism ◽  
General Amino Acid Control ◽  
Acid Control

scholarly journals Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis

2014 ◽  
Vol 55 (2) ◽  
pp. 264-276 ◽  
Author(s):  
Arindam Saha ◽  
Stephen Connelly ◽  
Jingjing Jiang ◽  
Shunhui Zhuang ◽  
Deron T. Amador ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nodal Point ◽  
Purine Synthesis ◽  
Akt Phosphorylation ◽  
Acid Control
Sign in / Sign up

Export Citation Format

Share Document