scholarly journals Biomechanics of Resistance Artery Wall Remodeling in Angiotensin-II Hypertension and Subsequent Recovery

2010 ◽  
Vol 33 (1) ◽  
pp. 37-47 ◽  
Author(s):  
György L. Nádasy ◽  
Szabolcs Várbíró ◽  
Mária Szekeres ◽  
Adrienn Kocsis ◽  
Béla Székács ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Resistance Artery ◽  
Artery Wall ◽  
Subsequent Recovery

Enhanced resistance artery sensitivity to agonists under isobaric compared with isometric conditions

1994 ◽  
Vol 266 (1) ◽  
pp. H147-H155 ◽  
Author(s):  
W. R. Dunn ◽  
G. C. Wellman ◽  
J. A. Bevan
Keyword(s):  
Membrane Potential ◽  
Angiotensin Ii ◽  
Myogenic Tone ◽  
Isometric Contractions ◽  
Fundamental Interaction ◽  
Resistance Artery ◽  
Resistance Arteries ◽  
Enhanced Resistance ◽  
Increased Sensitivity

We have compared the responsiveness of rabbit mesenteric resistance arteries with agonists under isometric and isobaric conditions. When pressurized (60 mmHg), arteries spontaneously reduced their diameter by 18.1%. An equivalent isometric stress did not generate force in a “wire” myograph. Subsequently, much higher concentrations of norepinephrine (NE) and histamine were required to cause isometric contractions than were needed to reduce vascular diameter of pressurized vessels, whereas angiotensin II produced a maintained response only in pressurized arteries. Reducing transmural pressure to 20 mmHg abolished pressure-induced myogenic tone and decreased arterial sensitivity to NE. Under isometric conditions, partial depolarization with KCl increased sensitivity to NE and histamine to within the concentration range effective in pressurized vessels and also "revealed" responses to angiotensin II. The membrane potential of the vascular smooth muscle cells under partially depolarized conditions was similar to that found in vivo and in vessels studied isobarically. These observations demonstrate a fundamental interaction between pressure-induced myogenic tone and the sensitivity of resistance arteries to vasoactive stimuli. This influence was mimicked in isometrically mounted vessels by partial depolarization, indicating a possible pivotal role for membrane potential in determining the reactivity of the resistance vasculature.

BLOCKADE OF ANGIOTENSIN II TYPE 1 RECEPTORS REDUCES RADIAL ARTERY WALL THICKNESS IN HYPERTENSIVES

2000 ◽  
Vol 18 ◽  
pp. S179-S180
Author(s):  
S. Gautier ◽  
A. Laflèche ◽  
B. Pannier ◽  
R. Asmar ◽  
X. Girerd ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Radial Artery ◽  
Wall Thickness ◽  
Artery Wall

Resistance artery wall and network remodeling in Ang-II hypertension

2009 ◽  
Author(s):  
György L. Nádasy ◽  
Szabolcs Várbíró ◽  
Mária Szekeres ◽  
Adrienn Kocsis ◽  
Béla Székács ◽  
...  
Keyword(s):  
Ang Ii ◽  
Resistance Artery ◽  
Artery Wall

RESISTANCE ARTERY MECHANICS AND COMPOSITION IN ANGIOTENSIN II-INFUSED MICE: EFFECTS OF CYCLOOXYGENASE-1 INHIBITION: PP.6.229

2010 ◽  
Vol 28 ◽  
pp. e118
Author(s):  
A Virdis ◽  
MF Neves ◽  
F Aydinoglu ◽  
E Daghini ◽  
E Duranti ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Resistance Artery ◽  
Cyclooxygenase 1

scholarly journals Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure

2015 ◽  
Vol 308 (5) ◽  
pp. H376-H385 ◽  
Author(s):  
Istvan Czikora ◽  
Attila Feher ◽  
Rudolf Lucas ◽  
David J. R. Fulton ◽  
Zsolt Bagi
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Cell Surface ◽  
Systemic Blood Pressure ◽  
Ang Ii ◽  
Resistance Artery ◽  
High Fat ◽  
Short Term ◽  
Systemic Blood ◽  
Caveolin 1

The type 1 angiotensin II (ANG II) receptor (AT1R) undergoes internalization following stimulation by ANG II. Internalization reduces cell surface AT1Rs, and it is required for AT1R resensitization. In this process AT1R may interact with caveolin-1 (Cav1), the main scaffolding protein of caveolae. We hypothesized that the interaction between Cav1 and AT1R delays AT1R resensitization and thereby prevents sustained ANG II-induced resistance artery (RA) constriction under normal conditions and in experimental obesity. In rat and mouse skeletal muscle RA (diameter: ∼90–120 μm) ANG II-induced constrictions were reduced upon repeated (30-min apart) administrations. Upon disruption of caveolae with methyl-β-cyclodextrin or in RA of Cav1 knockout mice, repeated ANG II applications resulted in essentially maintained constrictions. In vascular smooth muscle cells, AT1R interacted with Cav1, and the degree of cell surface interactions was reduced by long-term (15-min), but not short-term (2-min), exposure to ANG II. When Cav1 was silenced, the amount of membrane-associated AT1R was significantly reduced by a short-term ANG II exposure. Moreover, Cav1 knockout mice fed a high-fat diet exhibited augmented and sustained RA constriction to ANG II and had elevated systemic blood pressure, when compared with normal or high-fat fed wild-type mice. Thus, Cav1, through a direct interaction, delays internalization and subsequent resensitization of AT1R. We suggest that this mechanism prevents sustained ANG II-induced RA constriction and elevated systemic blood pressure in diet-induced obesity.

scholarly journals Morphological remodeling of the intramural coronary resistance artery network geometry in chronically Angiotensin II infused hypertensive female rats

Heliyon ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. e03807
Author(s):  
Anna Monori-Kiss ◽  
Peter Antal ◽  
Maria Szekeres ◽  
Szabolcs Varbiro ◽  
Alexander Fees ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Female Rats ◽  
Coronary Resistance ◽  
Resistance Artery ◽  
Network Geometry

scholarly journals Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition

2011 ◽  
Vol 33 (17) ◽  
pp. 2225-2234 ◽  
Author(s):  
Agostino Virdis ◽  
Rocchina Colucci ◽  
Mario Fritsch Neves ◽  
Ilaria Rugani ◽  
Fatma Aydinoglu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Resistance Artery ◽  
Cyclooxygenase 1

Resistance artery mechanics and composition in angiotensin II-infused rats

2003 ◽  
Vol 21 (1) ◽  
pp. 189-198 ◽  
Author(s):  
Mario Fritsch Neves ◽  
Agostino Virdis ◽  
Ernesto L Schiffrin
Keyword(s):  
Angiotensin Ii ◽  
Resistance Artery
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