Anorexia nervosa in Italy: Clinical Features and Outcome in a Long-Term Follow-Up Study

1987 ◽  
Vol 20 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Paolo Santonastaso ◽  
Gerardo Favaretto ◽  
Graziano Canton
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Features ◽  
Follow Up Study ◽  
Long Term Follow Up

Long-Term Follow-up Study of MRI-Guided Bilateral Anterior Capsulotomy in Patients With Refractory Anorexia Nervosa

Neurosurgery ◽  
2017 ◽  
Vol 83 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Wei Liu ◽  
Dianyou Li ◽  
Fafa Sun ◽  
Xiaoxiao Zhang ◽  
Tao Wang ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Memory Loss ◽  
Novel Treatments ◽  
Follow Up Study ◽  
Life Saving ◽  
Scale Scores ◽  
Long Term Follow Up ◽  
Anterior Capsulotomy

Abstract BACKGROUND Anorexia nervosa (AN) is one of the most challenging psychiatric disorders to treat. The poor clinical outcomes warrant novel treatments for AN, especially in severe and persistent cases. OBJECTIVE To explore the feasibility of magnetic resonance imaging-guided bilateral anterior capsulotomy in the treatment of refractory AN. METHODS Seventy-four patients diagnosed with refractory AN who underwent capsulotomy completed this 3-yr follow-up study. Outcomes included body mass index (BMI) and results from a series of psychiatric scales (for obsessive, depressive, and anxious symptoms) that were implemented at baseline (presurgery), and 1 mo, 1 yr, and 3 yr after surgery. RESULTS Compared to presurgical levels, BMI increased significantly at 1-yr and 3-yr follow-ups. Compared to presurgery scores, psychiatric scale scores were significantly improved at 1-mo postsurgery, and continued to remain low at the 1-yr and 3-yr follow-ups. In addition, Mini-Mental State Examination (MMSE) scores were in the normal range during the long-term follow-up. The most common short-term side effects included urinary incontinence (n = 7), sleep disorders (n = 8), and fatigue (n = 6). Long-term complications included disinhibition (n = 6), memory loss (n = 3), and lethargy (n = 4). No patient in this study experienced death or disability. CONCLUSION Capsulotomy enabled patients with refractory AN to normalize their weight, especially those in life-threatening conditions. While it appears to be an acceptable life-saving treatment, it is indicated only when fulfilling strict criteria given its complications and irreversibility.

scholarly journals Deep brain stimulation of the nucleus accumbens for treatment-refractory anorexia nervosa: A long-term follow-up study

2020 ◽  
Vol 13 (3) ◽  
pp. 643-649 ◽  
Author(s):  
Wei Liu ◽  
Shikun Zhan ◽  
Dianyou Li ◽  
Zhengyu Lin ◽  
Chencheng Zhang ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Deep Brain Stimulation ◽  
Nucleus Accumbens ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Treatment Refractory ◽  
Deep Brain ◽  
Stimulation Of

Anorexia nervosa—clinical features and long term follow-up

1968 ◽  
Vol 21 (5) ◽  
pp. 361-367 ◽  
Author(s):  
John F. Seidensticker ◽  
Manuel Tzagournis
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Features ◽  
Long Term Follow Up

scholarly journals Letter: Long-Term Follow-up Study of MRI-Guided Bilateral Anterior Capsulotomy in Patients With Refractory Anorexia Nervosa

Neurosurgery ◽  
2018 ◽  
Vol 83 (1) ◽  
pp. E39-E40 ◽  
Author(s):  
Marc Zanello ◽  
Philibert Duriez ◽  
Johan Pallud ◽  
Alexandre Roux ◽  
Tarek Sharshar ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Mri Guided ◽  
Anterior Capsulotomy

Value of family background and clinical features as predictors of long-term outcome in anorexia nervosa: four-year follow-up study of 41 patients

1975 ◽  
Vol 5 (4) ◽  
pp. 355-371 ◽  
Author(s):  
H. G. Morgan ◽  
G. F. M. Russell
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Features ◽  
Psychiatric Treatment ◽  
Psychiatric Hospitals ◽  
Term Outcome ◽  
Premorbid Personality ◽  
Long Term Outcome ◽  
Follow Up Study

SynopsisThis is a prognostic study on 41 patients with anorexia nervosa (including three males) who satisfied defined diagnostic criteria. The patients had all been admitted to a metabolic unit where the mainstay of treatment was nursing care aimed at rapid restoration of body weight. A follow-up was conducted after a minimum lapse of four years after each patient's discharge from hospital. The outcome of the patient's illness was expressed in terms of an ‘average outcome score’ and a ‘general outcome’. The series included a relatively high proportion of patients with a long illness who had received previous psychiatric treatment. Their families tended to come from higher social classes; a disturbed relationship with the patient was frequent. Premorbid disturbances in personality development were also common. The immediate response to treatment was excellent, with the majority of the patients returning to a normal weight, but relapses after discharge were common and readmissions were necessary in half the patients. At follow-up, the patients fell into the following defined categories: ‘good’ (39%), ‘intermediate’ (27%), ‘poor’ (29%), died (5%). Most of the patients who failed to recover continued to display the clinical features characteristic of anorexia nervosa. Among predictors of an unfavourable outcome were found a relatively late age of onset, a longer duration of illness, previous admissions to psychiatric hospitals, a disturbed relationship between the patient and other members of the family, and premorbid personality difficulties. It is suggested that the long-term outcome found in a series will depend more on factors influencing patient referral according to the severity of their illness, rather than on the method of treatment itself. The illness may last several years before eventual improvement or recovery, and a follow-up study must be extended over at least four years to be meaningful. An accurate prediction of eventual outcome is almost impossible, but late recoveries justify an optimistic outlook and continued therapeutic endeavour.

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