Hormonal Changes in Urine and Plasma in Patients with Various Testicular Tumours before and after Treatment

1973 ◽  
Vol 28 (2) ◽  
pp. 127-134 ◽  
Author(s):  
D. Lindenmeyer ◽  
D. Hornung ◽  
F. Körner
Keyword(s):  
Hormonal Changes ◽  
Testicular Tumours ◽  
Before And After

Parathyroid gland before and after cisplatin treatment

1987 ◽  
Vol 45 ◽  
pp. 860-861
Author(s):  
S.K. Aggarwal ◽  
J.M. Fadool
Keyword(s):  
Parathyroid Gland ◽  
Wistar Rats ◽  
Antitumor Agent ◽  
The Body ◽  
Cross Linking ◽  
Limiting Factor ◽  
Hormonal Changes ◽  
Primary Mechanism ◽  
Before And After ◽  
Dna Strands

Cisplatin (CDDP) a potent antitumor agent suffers from severe toxic side effects with nephrotoxicity being the major dose-limiting factor, The primary mechanism of its action has been proposed to be through its cross-linking DNA strands. It has also been shown to inactivate various transport enzymes and induce hypocalcemia and hypomagnesemia that may be the underlying cause for some of its toxicities. The present is an effort to study its influence on the parathyroid gland for any hormonal changes that control calcium levels in the body.Male Swiss Wistar rats (Crl: (WI) BR) weighing 200-300 g and of 60 days in age were injected (ip) with cisplatin (7mg/kg in normal saline). The controls received saline injections only. The animals were injected (iv) with calcium (0.5 ml of 10% calcium gluconate/day) and were killed by decapitation on day 1 through 5. Trunk blood was collected in heparinized tubes.

CHANGES IN THE CONCENTRATION OF PITUITARY AND STEROID HORMONES IN THE FOLLICULAR FLUID OF HUMAN GRAAFIAN FOLLICLES THROUGHOUT THE MENSTRUAL CYCLE

1975 ◽  
Vol 64 (3) ◽  
pp. 555-571 ◽  
Author(s):  
K. P. McNATTY ◽  
W. M. HUNTER ◽  
A. S. McNEILLY ◽  
R. S. SAWERS
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Follicular Fluid ◽  
Follicle Stimulating Hormone ◽  
Secretory Activity ◽  
Follicular Phase ◽  
Hormonal Changes ◽  
Peripheral Plasma ◽  
Before And After ◽  
Late Follicular Phase

SUMMARY The concentrations of FSH, LH, prolactin, oestradiol and progesterone were measured in peripheral plasma and follicular fluid of women throughout the menstrual cycle. With the exception of prolactin, concentrations of pituitary and steroid hormones in follicular fluid correlated with those in peripheral plasma. Follicle-stimulating hormone was present in a greater number of small follicles ( < 8 mm) during or just after the peaks of FSH in peripheral plasma. During the mid-follicular phase the concentration of both FSH and oestradiol in fluid from large follicles ( ≥ 8 mm) was high. During the late follicular phase the large follicles ( ≥ 8 mm) contained high amounts of progesterone in addition to oestradiol, low physiological levels of prolactin, and concentrations of LH and FSH about 30 and 60% respectively of those found in plasma. By contrast no large 'active' follicles ( ≥ 8 mm) were found during the luteal phase although many contained both LH and FSH. Luteinizing hormone was present in a proportion of small follicles ( < 8 mm) during the late follicular and early luteal but not at other stages of the menstrual cycle. It is suggested that a precise sequence of hormonal changes occur within the microenvironment of the developing Graafian follicle; the order in which they occur may be of considerable importance for the growth of that follicle and secretory activity of the granulosa cells both before and after ovulation.

Impact of Clomiphene Citrate on the Steroid Profile in Dysmetabolic Men with Low Testosterone Levels

2021 ◽  
Vol 53 (08) ◽  
pp. 520-528
Author(s):  
Carla Pelusi ◽  
Flamina Fanelli ◽  
Margherita Baccini ◽  
Giovanni De Pergola ◽  
Vincenzo Triggiani ◽  
...  
Keyword(s):  
Clomiphene Citrate ◽  
Serum Levels ◽  
Male Hypogonadism ◽  
Hormonal Changes ◽  
Double Blind ◽  
Adrenal Steroidogenesis ◽  
Steroid Profiling ◽  
Corticosteroid Binding Globulin ◽  
Before And After ◽  
17Β Estradiol

AbstractClomiphene citrate (CC) in male hypogonadism increases testosterone (T) and estrogen levels by stimulating pituitary gonadotropin release. Our group confirmed these hormonal changes in a randomized, cross-over, double-blind trial of CC versus placebo in addition to metformin, conducted in 21 obese dysmetabolic men with low T levels. However, we hypothesize that based on its mechanism of action, CC may directly or indirectly affect adrenal steroidogenesis. The aim of this sub-study was to better understand the changes in steroid levels and metabolism induced by CC treatment. We assessed 17α-hydroxypregnelone (17αOH-P5), dehydroepiandrosterone (DHEA), progesterone (P4), 17α-hydroxyprogesterone (17αOH-P4), androstenedione (A), T, dihydrotestosterone (DHT), estrone (E1), 17β-estradiol (E2), 11-deoxycortisol (11 S), cortisol (F), and cortisone (E) by LC-MS/MS, and corticosteroid binding globulin (CBG) by ELISA, before and after each treatment. In addition, free-F and steroid product/precursor ratios were calculated. We observed a significant change in serum levels induced by CC compared with placebo for 17αOH-P4, DHT, T, E2, E1, F, E, and CBG, but not free-F. In addition, compared to placebo, CC induced higher 17αOH-P4/P4, E2/E1, 17αOH-P4/17αOH-P5, A/17αOH-P4, T/A, E1/A, F/11 S, and F/E ratios. Therefore, besides the CC stimulating effect on testis steroidogenesis, our study showed increased F, E, but not free-F, levels, indicating changes in steroid metabolism rather than adrenal secretion stimulation. The steroid profiling also revealed the CC stimulation of the Δ5 rather than the Δ4 pathway, thus indicating considerable testicular involvement in the increased androgen secretion.

scholarly journals Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

2013 ◽  
Vol 169 (4) ◽  
pp. 503-510 ◽  
Author(s):  
M L Hendriks ◽  
T König ◽  
R S Soleman ◽  
T Korsen ◽  
R Schats ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Transvaginal Ultrasound ◽  
Ovarian Hormones ◽  
Pulse Interval ◽  
Hormonal Changes ◽  
Before And After ◽  
Mechanical Manipulation ◽  
Lh Secretion ◽  
Late Follicular Phase ◽  
Ovarian Syndrome

ObjectiveLittle is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. DesignProspective case–control study (2008–2010).MethodsTen PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation.ResultsAll PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P<0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (P=0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, P=0.67). None of the ovarian hormones (estradiol, progesterone, anti-Müllerian hormone, inhibin B, androstenedione and testosterone) changed in either group.ConclusionsOvarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic–pituitary system is the most reasonable explanation.

Effects of endurance training on hormonal responses to prolonged physical exercise in males

1993 ◽  
Vol 129 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Tommi J Vasankari ◽  
Urho M Kujala ◽  
Olli J Heinonen ◽  
Ilpo T Huhtaniemi
Keyword(s):  
Physical Exercise ◽  
Endurance Training ◽  
Venous Blood ◽  
Serum Testosterone ◽  
Hormonal Changes ◽  
Significant Trial ◽  
Significant Group ◽  
Prolonged Physical Exercise ◽  
Before And After ◽  
On The Road

The effect of several years' endurance training on hormonal changes during acute prolonged physical exercise was studied. In trial I, 13 cross-country skiers were studied before and after a 75-km ski race and 3 weeks later on a control day. In trial II, 10 trained and 8 untrained subjects bicycled for 4 h on the road with as high a performance level as possible. Venous blood samples were taken in both trials before and after the exercise. In trial I, serum concentrations of luteinizing hormone (p<0.01) and follicle-stimulating hormone (FSH, p <0.001) decreased more from morning to afternoon samples, and cortisol (p <0.001) and growth hormone (GH, p <0.001) increased more during the ski race when compared to the control day. Serum testosterone decreased during the ski race (p <0.01) but not on the control day. In trial II, a group difference was seen in serum FSH levels which was higher in the trained than untrained subjects at all three time points (F =4.66, p=0.046). A significant trial-group interaction (p =0.020) was seen in GH, the GH being lower before exercise and higher 2 h after exercise in the untrained subjects. There was a significant group contrast between pre- and post-exercise samples in testosterone (p = 0.021) and cortisol (p = 0.022). In conclusion, the higher basal FSH concentration in the trained versus untrained subjects may be a sign of compensated hypogonadism due to intensive chronic training or it may be due to dysfunction of Sertoli cells. Signs of adaptation to resist the hormonal changes caused by acute physical exercise can be seen in the trained subjects when compared to the untrained subjects.

scholarly journals Supportive Group Therapy untuk Menurunkan Kecemasan Ibu Hamil di Wilayah Puskesmas Srandakan

PSYCHE 165 ◽  
2021 ◽  
pp. 296-302
Author(s):  
Fahrunnisa Lanjarto ◽  
Raras Indah Fitriana
Keyword(s):  
Group Therapy ◽  
Pregnant Women ◽  
Group Discussion ◽  
Wilcoxon Test ◽  
Hormonal Changes ◽  
A Value ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental ◽  
Supportive Group

Pregnancy is time when a person experiences many changes, both physically and psychologically, making them more vulnerable to stress. This case happens because pregnant women experience hormonal changes that affect psychological and physical conditions during the pregnancy process. This study aims to determine the effect of group therapy using supportive techniques coupled with the provision of information needed to reduce anxiety in pregnant women. The data collection methods used in this study were observation, interviews, Focused Group Discussion (FGD), as well as pre-test and post-test using the Beck Anxiety Inventory (BAI). The research design using quasi-experimental with pre-test and post-test without control, the sample in the study consisted of 7 pregnant women who had mild to severe anxiety levels. The results of data analysis using non-parametric test with the Wilcoxon test showed a value of z = 2.731 and a value of p = 0.018 (p <0.05). The results showed a significant decrease in anxiety scores before and after following the group therapy process. Based on the results of the study, it can be concluded that there is an effect of supportive group therapy on pregnant women at the Srandakan Public Health Center.

scholarly journals Effects of creatine hydrochloride supplementation on physical performance and hormonal changes in soldiers

2021 ◽  
Vol 9 (1) ◽  
pp. 93-99
Author(s):  
Mohammad Milad Tayebi ◽  
Mitra Yousefpour ◽  
Laya Ghahari
Keyword(s):  
Physical Performance ◽  
Vertical Jump ◽  
Hormonal Changes ◽  
Power Performance ◽  
Mean Power ◽  
Wingate Anaerobic Test ◽  
Double Blind ◽  
Back Squat ◽  
Before And After ◽  
Army Soldiers

Purpose: The aim of this study was to examine the effects of 2 weeks of creatine hydrochloride (CrHCl) supplementation on physical performance and hormonal changes in army soldiers. Materials: Eighteen male army soldiers were randomly assigned in a double-blind fashion to either a CrHCl (n=9) or placebo (Pl) (n=9) groups. CrHCl group costumed 3g of creatine per day, whereas Pl group was given dextrose. Before and after supplementation period, the subjects performed a battery of performance tests including one repletion maximum (1RM) of bench press and back squat, vertical jump (VJ) and Wingate anaerobic test. In addition, blood samples were obtained to determine changes in testosterone and cortisol concentrations per and post supplementation. Results: There were significant increases in VJ, peak and mean power, and 1RM back squat test following the 2 weeks of CrHCl supplementation (p < 0.05) without any significant change for the Pl group. In addition significant changes were observed in testosterone and cortisol concentrations from before to after supplementation in CrHCl group (p < 0.05) and compared with Pl group (p=0.001). Conclusions: In conclusion, the present study indicates that CrHCl supplementation can improve VJ, power performance, 1RM back squat and hormonal changes in army soldiers.

scholarly journals Athletic Activity and Hormone Concentrations in High School Female Athletes

2015 ◽  
Vol 50 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Edward M. Wojtys ◽  
Mary L. Jannausch ◽  
Jennifer L. Kreinbrink ◽  
Siobán D. Harlow ◽  
MaryFran R. Sowers
Keyword(s):  
Physical Activity ◽  
High School ◽  
Body Composition ◽  
Athletic Training ◽  
Body Mass ◽  
Adolescent Girls ◽  
Female Athletes ◽  
Fat Body ◽  
Hormonal Changes ◽  
Before And After

Context: Physical activity may affect the concentrations of circulating endogenous hormones in female athletes. Understanding the relationship between athletic and physical activity and circulating female hormone concentrations is critical. Objective: To test the hypotheses that (1) the estradiol-progesterone profile of high school adolescent girls participating in training, conditioning, and competition would differ from that of physically inactive, age-matched adolescent girls throughout a 3-month period; and (2) athletic training and conditioning would alter body composition (muscle, bone), leading to an increasingly greater lean–body-mass to fat–body-mass ratio with accompanying hormonal changes. Design: Cohort study. Settings: Laboratory and participants' homes. Patients or Other Participants: A total of 106 adolescent girls, ages 14–18 years, who had experienced at least 3 menstrual cycles in their lifetime. Main Outcome Measure(s): Participants were prospectively monitored throughout a 13-week period, with weekly physical activity assessments and 15 urine samples for estrogen, luteinizing hormone, creatinine, and progesterone concentrations. Each girl underwent body-composition measurements before and after the study period. Results: Seventy-four of the 98 girls (76%) who completed the study classified themselves as athletes. Body mass index, body mass, and fat measures remained stable, and 17 teenagers had no complete menstrual cycle during the observation period. Mean concentrations of log(estrogen/creatinine) were slightly greater in nonathletes who had cycles of &lt;24 or &gt;35 days. Mean log(progesterone/creatinine) concentrations in nonathletes were less in the first half and greater in the second half of the cycle, but the differences were not statistically significant. Conclusions: A moderate level of athletic or physical activity did not influence urine concentrations of estrogen, progesterone, or luteinizing hormones. However, none of the participants achieved high levels of physical activity. A significant number (17%) of girls in both activity groups were amenorrheic during the 3-month study period.

Isolated ACTH deficiency accompanied by 'primary hypothyroidism' and hyperprolactinaemia

1983 ◽  
Vol 104 (4) ◽  
pp. 397-401 ◽  
Author(s):  
Tadayoshi Yoshida ◽  
Tetsuya Arai ◽  
Jinpei Sugano ◽  
Hiroshi Yarita ◽  
Hideo Yanagisawa
Keyword(s):  
Pituitary Gland ◽  
Primary Hypothyroidism ◽  
Hormonal Changes ◽  
Plasma Acth ◽  
Isolated Acth Deficiency ◽  
Acth Deficiency ◽  
Corticotrophin Releasing Factor ◽  
Lysine Vasopressin ◽  
Before And After

Abstract. A 55 year old man with isolated ACTH deficiency is reported. The lesion would appear to be located in the pituitary gland since plasma ACTH and cortisol did not respond to lysine vasopressin and corticotrophin releasing factor (CRF). A fall in T4, a rise in basal values of TSH, prolactin (Prl), LH and FSH, excessive responses of TSH and Prl to TRH, and hyperreactive responses of LH and FSH to LRH were observed. These hormonal changes were examined before and after administration of cortisol. The abnormality in these hormones might be caused by deficiency of long-term glucocorticoid.

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