Polymorphous Low-Grade Adenocarcinoma: A ‘New’ Salivary Gland Tumour

ORL ◽  
1991 ◽  
Vol 53 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Henrik B. Hellquist ◽  
Maciej Tytor
2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Rammohan Kumar ◽  
Srikant Natarajan ◽  
K.S. Sneha ◽  
Nunna Sai Chitra ◽  
Karen Boaz ◽  
...  

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.


Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S120
Author(s):  
Kathleen Young ◽  
Spinderjeet Samra ◽  
Hedley Coleman ◽  
Mark Tshuchnigg

2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.


2008 ◽  
Vol 36 ◽  
pp. S187-S188
Author(s):  
E. Sahuquillo-Arce ◽  
Gm. Barrios-Sanchez ◽  
F. Gomez-Lopez ◽  
Ma. Pla-Esparza ◽  
S. Garcera ◽  
...  

Author(s):  
R Zare ◽  
A Andisheh-Tadbir ◽  
N Moghadasi ◽  
BI Khademi ◽  
M Malekzadeh ◽  
...  

1974 ◽  
Vol 41 (4) ◽  
pp. 152-153
Author(s):  
R. M. Saboo ◽  
Raj Kumar

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