Epstein-Barr Virus Involvement in Salivary Gland Lesions Associated with Sjögren’s Syndrome

ORL ◽  
1990 ◽  
Vol 52 (4) ◽  
pp. 254-259 ◽  
Author(s):  
S. Syrjänen ◽  
V. Kärjä ◽  
Fuju Chang ◽  
B. Johansson ◽  
K. Syrjänen
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

scholarly journals Role of Viral Infections in the Pathogenesis of Sjögren’s Syndrome: Different Characteristics of Epstein-Barr Virus and HTLV-1

2020 ◽  
Vol 9 (5) ◽  
pp. 1459 ◽  
Author(s):  
Hideki Nakamura ◽  
Toshimasa Shimizu ◽  
Atsushi Kawakami
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Cell Leukemia Virus Type ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

Viruses are possible pathogenic agents in several autoimmune diseases. Sjögren’s syndrome (SS), which involves exocrine dysfunction and the appearance of autoantibodies, shows salivary gland- and lacrimal gland-oriented clinical features. Epstein-Barr virus (EBV) is the most investigated pathogen as a candidate that directly induces the phenotype found in SS. The reactivation of the virus with various stimuli induced a dysregulated form of EBV that has the potential to infect SS-specific B cells and plasma cells that are closely associated with the function of an ectopic lymphoid structure that contains a germinal center (GC) in the salivary glands of individuals with SS. The involvement of human T-cell leukemia virus type 1 (HTLV-1) in SS has been epidemiologically established, but the disease concept of HTLV-1-associated SS remains unexplained due to limited evidence from basic research. Unlike the cell-to-cell contact between lymphocytes, biofilm-like structures are candidates as the mode of HTLV-1 infection of salivary gland epithelial cells (SGECs). HTLV-1 can infect SGECs with enhanced levels of inflammatory cytokines and chemokines that are secreted from SGECs. Regardless of the different targets that viruses have with respect to affinitive lymphocytes, viruses are involved in the formation of pathological alterations with immunological modifications in SS.

Epstein-Barr Virus in the Sublabial Salivary Gland in Sjogren’s Syndrome

1989 ◽  
Vol 91 (4) ◽  
pp. 461-463 ◽  
Author(s):  
Henk-Jan Schuurman ◽  
Maike H. G. Schemmann ◽  
Roel A. De Weger ◽  
Henk Aanstoot ◽  
Ronald Hene
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

Normal serologic response to Epstein-Barr virus in patients with sjögren's syndrome

1989 ◽  
Vol 32 (6) ◽  
pp. 811-812 ◽  
Author(s):  
Patrick J. W. Venables ◽  
Christina Baboonian ◽  
Ravinder N. Maini ◽  
Nobuyuki Miyasaka ◽  
Kunio Yamaoka ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Barr Virus ◽  
Serologic Response ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

Epstein-Barr virus (types 1 and 2) in the tear film in Sjogren's syndrome and HIV infection

2002 ◽  
Vol 68 (3) ◽  
pp. 378-383 ◽  
Author(s):  
C.E. Willoughby ◽  
K. Baker ◽  
S.B. Kaye ◽  
P. Carey ◽  
N. O'Donnell ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Tear Film ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome
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