Human Endolymphatic Sac: Evidence for a Role in Inner Ear Immune Defence (With 1 color plate)

ORL ◽  
1990 ◽  
Vol 52 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Hans Jörg Altermatt ◽  
Jan-Olaf Gebbers ◽  
Christoph Müller ◽  
Wolfgang Arnold ◽  
Jean Albert Laissue
Keyword(s):  
Inner Ear ◽  
Endolymphatic Sac ◽  
Immune Defence ◽  
Color Plate

The Role of the Endolymphatic Sac in Inner Ear Immunity

1987 ◽  
Vol 103 (5) ◽  
pp. 182-188 ◽  
Author(s):  
Shunichi Tomiyama ◽  
Jeffrey Harris
Keyword(s):  
Inner Ear ◽  
Endolymphatic Sac

Gene Transfer to the Inner Ear Following Adenoviral Vector Inoculation into the Endolymphatic Sac.

2000 ◽  
Vol 59 (1) ◽  
pp. 45-51
Author(s):  
Tatsuya Yamasoba ◽  
Masao Yagi ◽  
Mitsuya Suzuki
Keyword(s):  
Gene Transfer ◽  
Inner Ear ◽  
Adenoviral Vector ◽  
Endolymphatic Sac

The Role of the Endolymphatic Sac in Inner Ear Immunity

1987 ◽  
Vol 103 (3-4) ◽  
pp. 182-188 ◽  
Author(s):  
Shunichi Tomiyama ◽  
Jeffrey P. Harris
Keyword(s):  
Inner Ear ◽  
Endolymphatic Sac

The Endolymphatic Sac as the Immunocompetent Organ of the Inner Ear

1997 ◽  
Vol 830 (1 Immunologic D) ◽  
pp. 243-252 ◽  
Author(s):  
M. BARBARA ◽  
G. ATTANASIO ◽  
V. PETROZZA ◽  
A. MODESTI ◽  
R. FILIPO
Keyword(s):  
Inner Ear ◽  
Endolymphatic Sac ◽  
Immunocompetent Organ

scholarly journals Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window

2010 ◽  
Vol 120 (10) ◽  
pp. 2054-2060 ◽  
Author(s):  
Yiliang Zhang ◽  
Ru Zhang ◽  
Chunfu Dai ◽  
Peter S. Steyger ◽  
Yongfu Yu
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Endolymphatic Sac

scholarly journals Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac

2016 ◽  
Vol 230 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Martin N. Møller ◽  
Svend Kirkeby ◽  
Per Cayé-Thomasen
Keyword(s):  
Inner Ear ◽  
Immune Defense ◽  
Innate Immune ◽  
Endolymphatic Sac ◽  
Innate Immune Defense

Pathophysiologic Findings in the Human Endolymphatic Sac in Endolymphatic Hydrops: Functional and Molecular Evidence

2019 ◽  
Vol 128 (6_suppl) ◽  
pp. 76S-83S ◽  
Author(s):  
Sung Huhn Kim ◽  
Gi-Sung Nam ◽  
Jae Young Choi
Keyword(s):  
Inner Ear ◽  
Animal Studies ◽  
Endolymphatic Hydrops ◽  
Single Layer ◽  
Sensory Epithelium ◽  
Endolymphatic Sac ◽  
Molecular Evidence ◽  
Limited Opportunity ◽  
Basic Studies

Background: The endolymphatic sac (ES) is a cystic structure situated on the posterior fossa dura and is connected to the luminal space of the vestibular organ through the endolymphatic duct, which branches into the utricular and saccular ducts. Unlike the cochlea and vestibule, the ES does not contain sensory epithelium in its luminal space, and a single layer of epithelial cells line the luminal surface area. The ES in the inner ear is thought to play a role in the regulation of inner ear homeostasis, fluid volume, and immune reaction. If these functions of the ES are disrupted, dysfunction of the inner ear may develop. The most well-known pathology arising from dysfunction of the ES is endolymphatic hydrops, characterized by an enlarged endolymphatic space due to the accumulation of excessive endolymphatic fluid. Although, molecular identities and functional evidence for the roles were identified in animal studies, basic studies of the human ES are relatively uncommon compared with those using animal tissues, because of limited opportunity to harvest the human ES. Methods: In this study, molecular and functional evidence for the role of the human ES in the development of endolymphatic hydrops are reviewed. Results and Conclusions: Although evidence is insufficient, studies using the human ES have mostly produced findings similar to those of animal studies. This review may provide a basis for planning further studies to investigate the pathophysiology of disorders with the finding of endolymphatic hydrops.

Large Na+ influx and high Na+, K+–ATPase activity in mitochondria-rich epithelial cells of the inner ear endolymphatic sac

2006 ◽  
Vol 453 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Takenori Miyashita ◽  
Hitoshi Tatsumi ◽  
Kimihide Hayakawa ◽  
Nozomu Mori ◽  
Masahiro Sokabe
Keyword(s):  
Epithelial Cells ◽  
Atpase Activity ◽  
Inner Ear ◽  
Endolymphatic Sac

Endolymphatic sac tumor with overexpression of V2 receptor mRNA and inner ear hydrops

2011 ◽  
Vol 131 (9) ◽  
pp. 951-957 ◽  
Author(s):  
Tadashi Kitahara ◽  
Chie Maekawa ◽  
Kaoru Kizawa ◽  
Takefumi Kamakura ◽  
Arata Horii ◽  
...  
Keyword(s):  
Inner Ear ◽  
Endolymphatic Sac ◽  
Endolymphatic Sac Tumor ◽  
Receptor Mrna ◽  
V2 Receptor
Sign in / Sign up

Export Citation Format

Share Document