Infection of Human Epithelial Cell Lines by Epstein-Barr Virus

ORL ◽  
1984 ◽  
Vol 46 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Tom Takimoto ◽  
Kazuo Morishita ◽  
Ryozo Umeda ◽  
Hisashi Ogura ◽  
Motoichi Hatano
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Human Epithelial Cell ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Epstein Barr

scholarly journals Tumorigenesis of Epstein–Barr Virus-Positive Epithelial Cell Lines Derived from Gastric Tissues in the SCID Mouse

Virology ◽  
2000 ◽  
Vol 277 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Masanao Murakami ◽  
Yoshiko Hoshikawa ◽  
Yukio Satoh ◽  
Hisao Ito ◽  
Masako Tajima ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Scid Mouse ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Epstein Barr

Spontaneous reduction in Epstein-Barr virus (EBV) DNA copy number in EBV-infected epithelial cell lines

2001 ◽  
Vol 3 (13) ◽  
pp. 1085-1091 ◽  
Author(s):  
Mikiko Kanamori ◽  
Masanao Murakami ◽  
Tomoko Takahashi ◽  
Nanao Kamada ◽  
Masako Tajima ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Copy Number ◽  
Epstein Barr Virus ◽  
Spontaneous Reduction ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Infected Epithelial Cell

scholarly journals Infectious Epstein-Barr Virus Lacking Major Glycoprotein BLLF1 (gp350/220) Demonstrates the Existence of Additional Viral Ligands

2000 ◽  
Vol 74 (21) ◽  
pp. 10142-10152 ◽  
Author(s):  
Annette Janz ◽  
Muhsin Oezel ◽  
Christian Kurzeder ◽  
Josef Mautner ◽  
Dagmar Pich ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Target Cells ◽  
Wild Type ◽  
Viral Glycoprotein ◽  
Barr Virus ◽  
Viral Mutant ◽  
Epithelial Cell Lines ◽  
Epstein Barr

ABSTRACT The binding of the viral major glycoprotein BLLF1 (gp350/220) to the CD21 cellular receptor is thought to play an essential role during infection of B lymphocytes by the Epstein-Barr virus (EBV). However, since CD21-negative cells have been reported to be infectible with EBV, additional interactions between viral and cellular molecules seem to be probable. Based on a recombinant genomic EBV plasmid, we deleted the gene that encodes the viral glycoprotein BLLF1. We tested the ability of the viral mutant to infect different lymphoid and epithelial cell lines. Primary human B cells, lymphoid cell lines, and nearly all of the epithelial cell lines that are susceptible to wild-type EBV infection could also be successfully infected with the viral mutant in vitro, although the efficiency of infection with BLLF1-negative virus was clearly lower than the one observed with wild-type EBV. Our studies show that the interaction between BLLF1 and CD21 is not absolutely required for the infection of lymphocytes and epithelial cells, indicating that viral molecules other than BLLF1 can mediate the binding of EBV to its target cells. In this context, our results further suggest the hypothesis that additional cellular molecules, apart from CD21, allow virus entry into these cells.

scholarly journals Productive Infection of Epstein–Barr Virus (EBV) in EBV-Genome-Positive Epithelial Cell Lines (GT38 and GT39) Derived from Gastric Tissues

Virology ◽  
1998 ◽  
Vol 247 (2) ◽  
pp. 152-159 ◽  
Author(s):  
Noriko Takasaka ◽  
Masako Tajima ◽  
Kota Okinaga ◽  
Yukio Satoh ◽  
Yoshiko Hoshikawa ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Productive Infection ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Epstein Barr
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