scholarly journals Differential Modulation of Sonic-Hedgehog-Induced Cerebellar Granule Cell Precursor Proliferation by the IGF Signaling Network

2010 ◽  
Vol 32 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Carla Fernandez ◽  
Valérie M. Tatard ◽  
Nicolas Bertrand ◽  
Nadia Dahmane
Keyword(s):  
Sonic Hedgehog ◽  
Granule Cell ◽  
Signaling Network ◽  
Cerebellar Granule Cell ◽  
Differential Modulation ◽  
Cell Precursor ◽  
Cerebellar Granule ◽  
Granule Cell Precursor ◽  
Igf Signaling

scholarly journals A Role for p27/Kip1 in the Control of Cerebellar Granule Cell Precursor Proliferation

2000 ◽  
Vol 20 (15) ◽  
pp. 5756-5763 ◽  
Author(s):  
Kazuhiro Miyazawa ◽  
Toshiyuki Himi ◽  
Veronica Garcia ◽  
Hisakazu Yamagishi ◽  
Shigeaki Sato ◽  
...  
Keyword(s):  
Granule Cell ◽  
Cerebellar Granule Cell ◽  
Cell Precursor ◽  
Cerebellar Granule ◽  
Granule Cell Precursor ◽  
P27 Kip1

scholarly journals Multifaceted functions of Rab23 on primary cilium and Hedgehog signaling-mediated granule cell proliferation

2020 ◽  
Author(s):  
CHH Hor ◽  
WY Leong ◽  
ELK Goh
Keyword(s):  
Sonic Hedgehog ◽  
Primary Cilium ◽  
Granule Cell ◽  
Hedgehog Signaling ◽  
Cell Precursor ◽  
Shh Signaling ◽  
Shh Pathway ◽  
Granule Cell Precursor

AbstractSonic Hedgehog (Shh) signaling from the primary cilium drives cerebellar granule cell precursor (GCP) proliferation. Mutations of hedgehog (Hh) pathway repressors could cause medulloblastoma, the most prevalent and malignant childhood brain tumor that arises from aberrant GCP proliferation. We demonstrate that brain-specific knockout of a Shh pathway repressor Rab23 in mice caused mis-patterning of cerebellar folia and elevated GCP proliferation during early development, but with no prevalent occurrence of medulloblastoma at adult stage. Strikingly, Rab23-depleted GCPs exhibited up-regulated basal level of Shh pathway activities despite reduced ciliation, and were desensitized against stimulations by Shh and Smoothened (Smo) agonist in primary GCP culture. These results illustrate dual functions of Rab23 in repressing the basal level of Shh signaling, while facilitating Shh signal transduction via Shh/Smo on primary cilium. Collectively, our findings unravel instrumental roles of Rab23 in GCP proliferation and ciliogenesis. Rab23’s potentiation of Shh signaling pathway through the primary cilium and Smo, suggests a potential new therapeutic for Smo/primary cilium-driven medulloblastoma.Author SummaryC.H.H conceived, designed, lead, and performed all in vitro and in vivo experiments, analyzed data and wrote the manuscript. W.Y performed QPCR experiments and primary GCP cultures and analyzed data. E.L.G conceived and directed the study.

scholarly journals Cerebellar granule cell axons support high-dimensional representations

2021 ◽  
Author(s):  
Frederic Lanore ◽  
N. Alex Cayco-Gajic ◽  
Harsha Gurnani ◽  
Diccon Coyle ◽  
R. Angus Silver
Keyword(s):  
Granule Cell ◽  
Cerebellar Granule Cell ◽  
High Dimensional ◽  
Cerebellar Granule
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