scholarly journals Apoptosis of Oligodendrocytes and Post-Translational Modifications of Myelin Basic Protein in Multiple Sclerosis: Possible Role for the Early Stages of Multiple Sclerosis

2010 ◽  
Vol 63 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Artemios K. Artemiadis ◽  
Maria C. Anagnostouli
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Post Translational Modifications ◽  
Early Stages

MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis

2015 ◽  
Vol 472 (1) ◽  
pp. 17-32 ◽  
Author(s):  
Kenrick A. Vassall ◽  
Vladimir V. Bamm ◽  
George Harauz
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Basic Protein ◽  
Intrinsically Disordered Proteins ◽  
Basic Protein ◽  
Disordered Proteins ◽  
Post Translational Modifications ◽  
Src Homology 3 ◽  
Intrinsically Disordered ◽  
Src Homology ◽  
Membrane Anchoring

The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The predominant 18.5-kDa isoform links together the cytosolic surfaces of oligodendrocytes, but additionally participates in cytoskeletal turnover and membrane extension, Fyn-mediated signalling pathways, sequestration of phosphoinositides and maintenance of calcium homoeostasis. All MBP isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions. Their conformations and associations are modulated by environment and by a dynamic barcode of post-translational modifications, particularly phosphorylation by mitogen-activated and other protein kinases and deimination [a hallmark of demyelination in multiple sclerosis (MS)]. The MBPs are thus to myelin what basic histones are to chromatin. Originally thought to be merely structural proteins forming an inert spool, histones are now known to be dynamic entities involved in epigenetic regulation and diseases such as cancer. Analogously, the MBPs are not mere adhesives of compact myelin, but active participants in oligodendrocyte proliferation and in membrane process extension and stabilization during myelinogenesis. A central segment of these proteins is pivotal in membrane-anchoring and SH3 domain (Src homology 3) interaction. We discuss in the present review advances in our understanding of conformational conversions of this classic basic protein upon membrane association, including new thermodynamic analyses of transitions into different structural ensembles and how a shift in the pattern of its post-translational modifications is associated with the pathogenesis and potentially onset of demyelination in MS.

scholarly journals T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

Immunology ◽  
2008 ◽  
Vol 125 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Chris J. Hedegaard ◽  
Martin Krakauer ◽  
Klaus Bendtzen ◽  
Henrik Lund ◽  
Finn Sellebjerg ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Helper Cell Type

scholarly journals Urinary Myelin Basic Protein–like Material in Patients With Multiple Sclerosis During Interferon Beta-1b Treatment

1999 ◽  
Vol 56 (6) ◽  
pp. 687 ◽  
Author(s):  
John N. Whitaker ◽  
Beverly A. Layton ◽  
Alfred A. Bartolucci ◽  
Galen W. Mitchell ◽  
Khurram Bashir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Basic Protein ◽  
Interferon Beta ◽  
Basic Protein

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Nature ◽  
1993 ◽  
Vol 362 (6415) ◽  
pp. 68-70 ◽  
Author(s):  
Jorge R. Oksenberg ◽  
Michael A. Panzara ◽  
Ann B. Begovich ◽  
Dennis Mitchell ◽  
Henry A. Erlich ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
T Cell Receptor ◽  
Basic Protein ◽  
Cell Receptor ◽  
Brain Lesions ◽  
Gene Rearrangements ◽  
Selection For ◽  
T Cell Receptor Vβ

Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis

1989 ◽  
Vol 22 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Constantin N. Baxevanis ◽  
George J. Reclos ◽  
Catherine Servis ◽  
Emmanuel Anastasopoulos ◽  
Paula Arsenis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Lymphocytes ◽  
Myelin Basic Protein ◽  
Basic Protein
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