Effects of Mucin Ophthalmic Solution on Epithelial Wound Healing in Rabbit Cornea

1997 ◽  
Vol 29 (2) ◽  
pp. 61-66 ◽  
Author(s):  
Toshiro Shigemitsu ◽  
Yoshito Shimizu ◽  
Yoshiao Majima
Keyword(s):  
Wound Healing ◽  
Ophthalmic Solution ◽  
Rabbit Cornea ◽  
Epithelial Wound Healing

scholarly journals Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing

2021 ◽  
Vol 14 (2) ◽  
pp. 88
Author(s):  
Yutaro Tobita ◽  
Takeshi Arima ◽  
Yuji Nakano ◽  
Masaaki Uchiyama ◽  
Akira Shimizu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ophthalmic Solution ◽  
Vehicle Group ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Corneal Epithelial ◽  
Ppar Agonist ◽  
Alkali Burn ◽  
Epithelial Wound Healing ◽  
Epithelial Healing

The effects of each subtype-selective peroxisome proliferator activated receptor (PPAR) agonist (α, β/δ, γ) on corneal epithelial wound healing were investigated using a rat corneal alkali burn model. After the alkali burn, each PPAR agonist or vehicle ophthalmic solution was instilled topically onto the rat’s cornea. Corneal epithelial healing processes were evaluated by fluorescein staining. Pathological analyses and real-time reverse transcription polymerase chain reactions were performed to evaluate Ki67 (proliferative maker) expression and inflammatory findings. The area of the corneal epithelial defect at 12 h and 24 h after the alkali burn was significantly smaller in each PPAR group than in the vehicle group. Ki67 mRNA expression was increased in the PPARβ/δ group, whereas mRNA expressions of inflammatory cytokines were suppressed in all of the PPAR agonist groups. Nuclear factor kappa B (NF-κB) was the most suppressed in the PPARγ group. The accelerated corneal epithelial healing effects of each PPAR ligand were thought to be related to the promotion of proliferative capacity and inhibition of inflammation.

Role of the C Domain of IGFs in Synergistic Promotion, with a Substance P–Derived Peptide, of Rabbit Corneal Epithelial Wound Healing

2004 ◽  
Vol 45 (4) ◽  
pp. 1125 ◽  
Author(s):  
Naoyuki Yamada ◽  
Ryoji Yanai ◽  
Masatsugu Nakamura ◽  
Makoto Inui ◽  
Teruo Nishida
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

In Vivo Confocal Microscopic Studies of Endothelial Wound Healing in Rabbit Cornea

Cornea ◽  
1993 ◽  
Vol 12 (5) ◽  
pp. 369-378 ◽  
Author(s):  
Hideji Ichijima ◽  
W Matthew Petroll ◽  
James V. Jester ◽  
Patricia A. Barry ◽  
Peter M. Andrews ◽  
...  
Keyword(s):  
Wound Healing ◽  
Rabbit Cornea ◽  
Microscopic Studies ◽  
Endothelial Wound Healing
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