Corneal Autofluorescence and Epithelial Barrier Function in Diabetic Patients

1995 ◽  
Vol 27 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Shu-Wen Chang ◽  
Hui-Chuan Hsu ◽  
Fung-Rong Hu ◽  
Muh-Shy Chen
Keyword(s):  
Barrier Function ◽  
Epithelial Barrier ◽  
Diabetic Patients ◽  
Epithelial Barrier Function ◽  
Corneal Autofluorescence

Corneal Epithelial Barrier Function in Diabetic Patients

Cornea ◽  
2004 ◽  
Vol 23 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Mamomu Gekka ◽  
Kazunori Miyata ◽  
Yuji Nagai ◽  
Shingo Nemoto ◽  
Tomokazu Sameshima ◽  
...  
Keyword(s):  
Barrier Function ◽  
Epithelial Barrier ◽  
Diabetic Patients ◽  
Epithelial Barrier Function ◽  
Corneal Epithelial

scholarly journals PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aubrey N. Michi ◽  
Bryan G. Yipp ◽  
Antoine Dufour ◽  
Fernando Lopes ◽  
David Proud
Keyword(s):  
Host Defense ◽  
Barrier Function ◽  
Bacterial Infections ◽  
Molecular Mechanisms ◽  
Cellular Damage ◽  
Epithelial Barrier ◽  
Airway Epithelial ◽  
Barrier Dysfunction ◽  
Epithelial Barrier Function ◽  
Epithelial Damage

AbstractHuman rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower airways diseases. Although viral induced epithelial damage mediates inflammation, the molecular mechanisms responsible for airway epithelial damage and dysfunction remain undefined. Using experimental HRV infection studies in highly differentiated human bronchial epithelial cells grown at air-liquid interface (ALI), we examine the links between viral host defense, cellular metabolism, and epithelial barrier function. We observe that early HRV-C15 infection induces a transitory barrier-protective metabolic state characterized by glycolysis that ultimately becomes exhausted as the infection progresses and leads to cellular damage. Pharmacological promotion of glycolysis induces ROS-dependent upregulation of the mitochondrial metabolic regulator, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), thereby restoring epithelial barrier function, improving viral defense, and attenuating disease pathology. Therefore, PGC-1α regulates a metabolic pathway essential to host defense that can be therapeutically targeted to rescue airway epithelial barrier dysfunction and potentially prevent severe respiratory complications or secondary bacterial infections.

The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease

2010 ◽  
Vol 4 (5) ◽  
pp. 637-651 ◽  
Author(s):  
Susanne A Snoek ◽  
Marleen I Verstege ◽  
Guy E Boeckxstaens ◽  
René M van den Wijngaard ◽  
Wouter J de Jonge
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Health And Disease
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