Maternal Age-Dependent and Sex-Related Changes of Gestational Serum Alpha-Fetoprotein

1995 ◽  
Vol 10 (6) ◽  
pp. 368-372 ◽  
Author(s):  
Maria Szabó ◽  
Lajos Veress ◽  
Ákos Münnich ◽  
Zoltán Papp
Keyword(s):  
Maternal Age ◽  
Alpha Fetoprotein ◽  
Age Dependent ◽  
Serum Alpha Fetoprotein

Reference Intervals for Serum Alpha-Fetoprotein and Carcinoembryonic Antigen in Chinese Han Ethnic Males from the Fangchenggang Area Male Health and Examination Survey

2011 ◽  
Vol 26 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Xue Qin ◽  
Liwen Lin ◽  
Zengnan Mo ◽  
Hui Lv ◽  
Yong Gao ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Reference Intervals ◽  
Alpha Fetoprotein ◽  
Male Health ◽  
Significant Difference ◽  
Reference Limits ◽  
Age Dependent ◽  
Serum Alpha Fetoprotein ◽  
Serum Cea ◽  
Normally Distributed

Objectives We calculated upper 95% reference limits for serum alpha-fetoprotein (AFP)and carcinoembryonic antigen (CEA) according to the CLSI/NCCLS C28-A3 guideline. Material and methods Serum samples from 1400 healthy male subjects were collected from the Fangchenggang Area Male Health and Examination Survey (FAMHES). Serum AFP and CEA values were measured by electrochemiluminescence immunoassay on COBAS 6000 system E601 (Elecsys module) immunoassay analyzers. Results Serum AFP and CEA values were not normally distributed but log normally distributed. The upper 95% reference limits of the reference intervals were ≤4.76 IU/mL (nonparametric) or ≤4.56 IU/mL (parametric) for AFP and ≤5.57 ng/mL (nonparametric) or ≤5.82 ng/mL (parametric) for CEA. The distribution of AFP levels was found to be consistent between the non-smoking and smoking (p=0.740) and non-drinking and drinking groups (p=0.698). The distribution of serum CEA levels was significantly higher in the smoking than the non-smoking group (p<105), whereas there was no significant difference in this respect between the non-drinking and drinking groups (p=0.147). A significant increase with age was found both for serum AFP and CEA levels, and the age-dependent reference intervals were calculated. Conclusions The reference intervals for serum AFP and CEA show a slight deviation compared to previously reported reference levels. Distinct reference intervals of serum CEA must be established for smoking and non-smoking populations. In addition, age-dependent reference intervals should be implemented in clinical laboratories.

Screening for Down's syndrome using an iso-risk curve based on maternal age and serum alpha-fetoprotein level

1987 ◽  
Vol 94 (7) ◽  
pp. 636-642 ◽  
Author(s):  
ANN TABOR ◽  
SEVERIN OLESEN LARSEN ◽  
JAN NIELSEN ◽  
JOHANNES NIELSEN ◽  
JOHN PHILIP ◽  
...  
Keyword(s):  
Maternal Age ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Alpha Fetoprotein ◽  
Risk Curve ◽  
Serum Alpha Fetoprotein

Hepatoid adenocarcinoma of the lung and the review of the literature

2020 ◽  
Vol 26 (6) ◽  
pp. 1505-1510
Author(s):  
Onder Tonyali ◽  
Onur Gonullu ◽  
Mehmet Akif Ozturk ◽  
Aysun Kosif ◽  
Ozlenen Gonca Civi
Keyword(s):  
Concurrent Chemoradiotherapy ◽  
Mediastinal Lymph Node ◽  
Alpha Fetoprotein ◽  
Disease Stage ◽  
Hepatoid Adenocarcinoma ◽  
Rare Type ◽  
Adenocarcinoma Of The Lung ◽  
Female Smoker ◽  
Diagnostic Biopsy ◽  
Serum Alpha Fetoprotein

Introduction Hepatoid adenocarcinoma of the lung is an extremely rare type of the non-small cell lung cancer. Treatment principles and prognosis are similar to that of lung adenocarcinoma. Case report A 62-year-old female smoker presented with a huge mass in the left upper lobe. After diagnostic biopsy, she underwent left pneumonectomy and mediastinal lymph node dissection. A diagnosis of stage T4N1M0 hepatoid adenocarcinoma of the lung with positive surgical margins was made. Management and outcome After the operation, the level of serum alpha fetoprotein was 9010 ng/ml (N: <10). The level of serum alpha fetoprotein was decreased with concurrent chemoradiotherapy and chemotherapy. Disease progression was detected at 11 months after diagnosis. No response was obtained to other therapies. The patient died at 14 months from the time of diagnosis. Discussion Usually, patients with hepatoid adenocarcinoma of the lung are male smokers. Hepatoid adenocarcinoma tends to settle in the upper lobes of the lung. The most important prognostic factor of the hepatoid adenocarcinoma of the lung is the disease stage at the diagnosis and patients with metastatic disease have poor survival.

Very Low Second-Trimester Maternal Serum Alpha-fetoprotein

2002 ◽  
Vol 99 (4) ◽  
pp. 531-536 ◽  
Author(s):  
Ahmet A. Baschat ◽  
Chris R. Harman ◽  
Gehan Farid ◽  
Bernard N. Chodirker ◽  
Jane A. Evans
Keyword(s):  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Second Trimester ◽  
Serum Alpha Fetoprotein
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