Monozygotic Twinning as a Congenital Defect and Congenital Defects in Monozygotic Twins

1990 ◽  
Vol 5 (2) ◽  
pp. 61-69 ◽  
Author(s):  
Barbara Luke ◽  
Louis G. Keith
Keyword(s):  
Monozygotic Twins ◽  
Congenital Defect ◽  
Congenital Defects ◽  
Monozygotic Twinning

Prune Belly Syndrome and Heart Defect in One of Monozygotic Twins, Following Exposure to Tigan and Bendectin

1985 ◽  
Vol 34 (1-2) ◽  
pp. 101-104 ◽  
Author(s):  
C. Greene ◽  
A. Wilson ◽  
E. Shapira
Keyword(s):  
Congenital Heart Defect ◽  
Congenital Heart ◽  
Monozygotic Twins ◽  
Hla Typing ◽  
Prune Belly Syndrome ◽  
Red Cell ◽  
Review Of The Literature ◽  
Monozygotic Twinning ◽  
Prune Belly ◽  
Heart Defect

AbstractOne of twins was bom with prune belly syndrome and congenital heart defect following exposure to Bendectin and Tigan. Red cell antigens and HLA typing were compatible with monozygosity. The possible associations of the prune belly syndrome to monozygotic twinning or to teratogenic agents is considered in light of this patient and review of the literature.

scholarly journals Monozygotic Triplets and Dizygotic Twins following Transfer of Three Poor-Quality Cleavage Stage Embryos

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Reshef Tal ◽  
Dmitry Fridman ◽  
Richard V. Grazi
Keyword(s):  
Preterm Labor ◽  
Fetal Heart ◽  
Monozygotic Twins ◽  
Clinical Importance ◽  
Poor Quality ◽  
Cleavage Stage ◽  
Monozygotic Twinning ◽  
Emergency Cesarean ◽  
Increased Risk ◽  
Selective Embryo Reduction

Background. Assisted reproductive technology has been linked to the increased incidence of monozygotic twinning. It is of clinical importance due to the increased risk of complications in multiple pregnancies in general and in monozygotic twins in particular.Case. A 29-year-old female, nulligravida underwent her first IVF cycle. Three poor-quality cleavage stage embryos were transferred resulting in monochorionic triamniotic triplets and dichorionic diamniotic twins. Selective embryo reduction was performed at 12 weeks leaving dichorionic twins. The patient underwent emergency cesarean section due to preterm labor and nonreassuring fetal heart tracing at 30 weeks of gestation.Conclusion. Our case emphasizes that even embryos with significant morphological abnormalities should be considered viable and the possibility of simultaneous spontaneous embryo splitting must be factored into determining number of embryos to transfer.

scholarly journals HYPERTROPHIC CARDIOMYOPATHY WITH PARTIAL ANOMALOUS PULMONARY VENOUS CONNECTION AND ATRIAL SEPTAL DEFECT: A RARE PRESENTATION

2017 ◽  
Vol 10 (8) ◽  
pp. 5
Author(s):  
Alphonsa M ◽  
Karthik R ◽  
Satish C Gowda ◽  
Navin Patil ◽  
Balaji O ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Medical Literature ◽  
Congenital Defect ◽  
Congenital Defects ◽  
Clinical Expression ◽  
Rare Presentation ◽  
Anomalous Pulmonary Venous Connection

Hypertrophic cardiomyopathy (HOCM) is characterized by heterogeneous clinical expression, unique pathophysiology, and diverse natural history.Coexistence of arterial septal defect and partial anomalous pulmonary venous connection (PAPVC) is very rare. Since HOCM is a congenital defect,coexistence of other congenital defects should be kept in mind when we treat the patients. Only very few cases of HOCM with coexisting congenitalanomalies have been reported so far in medical literature. Hence, we report a case of HOCM with atrial septal defect and PAPVC in a 49-year-old malepatient.

Congenital Hydranencephaly/Porencephaly Due to Vascular Disruption in Monozygotic Twins

PEDIATRICS ◽  
1984 ◽  
Vol 73 (4) ◽  
pp. 467-469
Author(s):  
Jack H. Jung ◽  
John M. Graham ◽  
Nancy Schultz ◽  
David W. Smith
Keyword(s):  
Monozygotic Twins ◽  
Recurrence Risk ◽  
Careful Examination ◽  
Monozygotic Twinning ◽  
Vascular Disruption ◽  
The Common ◽  
Common Association

Monozygotic twinning has been associated with a variety of vascular disruptive defects including congenital hydranencephaly/porencephaly. Data involving 24 cases of congenital hydranencephaly/porencephaly associated with twinning are reported. In these cases, the finding of a preponderance of monozygotic twins and the common association of a deceased co-twin support the hypothesis of a vascular disruptive etiology. These defects are presumed to be secondary to embolic phenomena or thromboplastin release from the deceased co-twin to the survivor via the vascular interconnections of a conjoined monochorionic placenta. In all cases of hydranencephaly/porencephaly, a careful examination of the placenta and membranes for evidence of a deceased co-twin is warranted prior to providing recurrence risk counseling.

scholarly journals Congenital Perineal Groove Defect in Monozygotic Twin Infants: A Literature Review

2021 ◽  
Vol 11 (01) ◽  
pp. e54-e57
Author(s):  
Mimily Harsono ◽  
David Yanishevski ◽  
Massroor Pourcyrous
Keyword(s):  
Congenital Anomaly ◽  
Monozygotic Twins ◽  
Expectant Management ◽  
Monozygotic Twin ◽  
Congenital Defect ◽  
Surgical Correction ◽  
Female Predominance ◽  
Parental Counseling ◽  
Good Hygiene

AbstractPerineal groove is a rare benign congenital anomaly with lesion that resembles perforation of mid-perineum or perineal raphe area. Most reported cases of congenital perineal groove presented as an isolated defect in term or early-term singleton female infants. Thus far, there is no reported case of this anomaly in monozygotic twins. Embryo pathogenesis of this female predominance congenital defect remains controversial. Many clinicians are unfamiliar with this congenital anomaly. This congenital defect tends to get self-resolved at around 2 year of age. Nevertheless, the exposed nonepithelized mucous membrane can carry risk of local infection or irritation with the possibility of requiring early surgical correction. The defect can be infrequently associated with other ano-urogenital malformations that required immediate surgical intervention. Most isolated cases tend to be asymptomatic and self-healed with expectant management. Surgical correction may be considered if not healed after 2 years of age. Early diagnosis at birth is important to avoid misdiagnoses at later age for trauma, dermatitis, sexual abuse, and risk of unnecessary aggressive intervention. Early parental counseling for providing good hygiene and close follow-up is important to prevent infection or inflammation. Presentation of this anomaly in both monozygotic twins may support the hypothesis of potential disruption during embryo morphogenesis stages.

On the Possible Cause of Monozygotic Twinning: Lessons From the 9-Banded Armadillo and From Assisted Reproduction

2007 ◽  
Vol 10 (2) ◽  
pp. 394-399 ◽  
Author(s):  
Isaac Blickstein ◽  
Louis G. Keith
Keyword(s):  
Assisted Reproduction ◽  
Monozygotic Twins ◽  
Infertility Treatment ◽  
Monozygotic Twinning ◽  
Dependent Relationship ◽  
Distinct Cell ◽  
Different Populations ◽  
Dose Dependent ◽  
Possible Cause ◽  
Hypothetical Explanation

AbstractAvailable hypotheses proposed to explain the mechanism of zygotic splitting fail to explain why monozygotic twins are more prevalent after all methods of assisted reproduction and which structure is likely to control this phenomenon. Arguably, a small proportion of oocytes might have an inborn propensity to undergo splitting upon fertilization leading to the constant prevalence of spontaneous monozygotic conceptions among different populations. Ovarian stimulation would then predictably increase the number of available splitting-prone oocytes and consequently would increase the chance for such oocytes to develop into monozygotic twins, leading to a ‘dose’-dependent relationship between monozygosity rates and the combined effect of infertility treatment. Embryonic division into 2 distinct cell lines begins and accommodates within an intact zona pellucida that controls the process by preventing ill-timed hatching. Human fertilized oocytes are able to undergo 2 binary fissions, just as is the case for the 9-banded armadillo (the only other mammal that produces monozygotic quadruplets) and to give rise to a variety of combinations of monozygotic pregnancies. This hypothetical explanation does not negate the already existing and genetically sound hypotheses, but places them into a broader perspective that respects recent observations from modern infertility treatment.

scholarly journals The Potency of ∆F 508-T Gen Mutant the Coding of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) As Prototype at the Congenital Bilateral Absence of Vas Deferens (CBAVD) Disease in Indonesia

2017 ◽  
Vol 3 (6) ◽  
pp. 139
Author(s):  
Maslichah Mafruchati ◽  
Mas’ud Harijadi ◽  
Widjiati Widjiati ◽  
Boerhan Hidayat
Keyword(s):  
Birth Defect ◽  
Congenital Defect ◽  
Congenital Defects ◽  
Prenatal Period ◽  
Gene Target ◽  
Optimal Output ◽  
Bilateral Absence ◽  
The World ◽  
Congenital Condition ◽  
Genetic Anomaly

Birth defect (congenital defect / congenital condition) is an anomaly appearing at birth and able to cause the physical or mental defect or death. Birth defect generally can be detected during the prenatal period. However, if this cannot be detected during the prenatal period, it can be identified at the post natal examination. Congenital Bilateral Absence Vas Difference (CBAVD) is of one the congenital defects characterized by Azoospermia causing the occurrence of infertility. This congenital defect can bring impact to the structural, functional and metabolism anomalies. Approximately 7.9 million children in the world (about 6% of the whole anomalies in the world) were born with serious congenital defects every year due to genetic anomaly or other post-conception. The determination of optimal output from PCR optimization to obtain the location of ∆F 508-T mutant on CBAVD patients in Indonesia is conducted pursuant to the gene target. The conclution were influence of various factors as the indicator specifying the mutation of ∆F 508-T mutant needs to be considered in making a decision for the preliminary research on CBAVD in Indonesia.

scholarly journals Serological and Hematological Study of Toxoplasmosis in Blood of Newly Born Babies

2021 ◽  
Vol 2 (3) ◽  
pp. 102-106
Author(s):  
Khairy A. Dawood Assit ◽  
Ruaa A. Talib ◽  
Hasanain Falah
Keyword(s):  
Elisa Test ◽  
Congenital Defect ◽  
Congenital Defects ◽  
Control Group ◽  
Normocytic Anemia ◽  
Blood Picture ◽  
Other Hand ◽  
Serological Identification ◽  
Group Unknown

Serological identification and blood pictures were done for specific IgM and IgG.10% of cases were positive IgM of Toxoplasmosis because have 10 IU/ml (mean) in comparison with control group were 0.11 IU/ml (mean). On other hand 20% of diagnosed cases were positive IgG of Toxoplasmosis because have 11 IU/ml .Two cases were followed for their history one from group IgM and other IgG , first one suffered from three abortion and now have five child three of them healthy while two have congenital defects. Second case (IgG positive ) have four abortion and now have three child , two healthy and one have congenital defect. Blood picture reveal 40% suffered from Normocytic anemia , these cases classified to three groups , first Toxoplasma group 30% (positive in ELISA test). Second group (Unknown causes), these cases not only normocytic anemia also have high total leukocytes 17 x10 (mean) and high MCV (103 ft). Third group have low MCV 78ft.

scholarly journals Maternal and perinatal aspects of birth defects: a case-control study

2014 ◽  
Vol 32 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Geiza Cesar Nhoncanse ◽  
Carla Maria R. Germano ◽  
Lucimar Retto da S. de Avo ◽  
Debora Gusmao Melo
Keyword(s):  
Birth Defects ◽  
Case Control Study ◽  
Case Control ◽  
Congenital Defect ◽  
Birth Certificates ◽  
Treatment Programs ◽  
Congenital Defects ◽  
Chi Square ◽  
Epidemiological Monitoring ◽  
Control Study

Objective: To assess the prevalence of congenital defects and to investigate their maternal and perinatal associated aspects by reviewing Birth Certificates. Methods: Among all born alive infants from January 2003 to December 2007 in Maternidade da Santa Casa de Misericórdia of São Carlos, Southeast Brazil (12,199 infants), cases were identified as the newborns whose Birth Certificates registered any congenital defect. The same sex neonate born immediately after the case was chosen as a control. In total, 13 variables were analyzed: six were maternal related, three represented labor and delivery conditions and four were linked to fetal status. The chi-square and Fisher's exact tests were used to compare the variables, being significant p<0.05. Results: The prevalence of congenital defects was 0.38% and the association of two or more defects represented 32% of all cases. The number of mothers whose education level was equal or less than eight years was significantly higher among the group with birth defects (p=0.047). A higher frequency of prematurity (p<0.001) and cesarean delivery (p=0.004) was observed among children with birth defects. This group also showed lower birth weight and Apgar scores in the 1st and the 5th minute (p<0.001). Conclusions: The prevalence of congenital defect of 0.38% is possibly due to underreporting. The defects notified in the Birth Certificates were only the most visible ones, regardless of their severity. There is a need of adequate epidemiological monitoring of birth defects in order to create and expand prevention and treatment programs.

Sign in / Sign up

Export Citation Format

Share Document