Role of Pericytes in Vascular Biology

2009 ◽  
pp. 194-202
Author(s):  
Annika Armulik ◽  
Christer Betsholtz
Keyword(s):  
Vascular Biology

scholarly journals Role of Mechanotransduction in Vascular Biology

2015 ◽  
Vol 116 (8) ◽  
pp. 1448-1461 ◽  
Author(s):  
Jay D. Humphrey ◽  
Martin A. Schwartz ◽  
George Tellides ◽  
Dianna M. Milewicz
Keyword(s):  
Vascular Biology

scholarly journals The Role of Autophagy in Vascular Biology

2015 ◽  
Vol 116 (3) ◽  
pp. 480-488 ◽  
Author(s):  
Samuel C. Nussenzweig ◽  
Subodh Verma ◽  
Toren Finkel
Keyword(s):  
Vascular Biology

Functional role of protease activated receptors in vascular biology

2014 ◽  
Vol 62 (2) ◽  
pp. 72-81 ◽  
Author(s):  
Maria Adele Alberelli ◽  
Erica De Candia
Keyword(s):  
Functional Role ◽  
Vascular Biology ◽  
Protease Activated Receptors

scholarly journals Vascular Biology of Diabetic Macroangiopathy: Role of Nonenzymatic Glycation of Extracellular matrix in Atherogenesis

1996 ◽  
Vol 24 (3) ◽  
pp. 107-115 ◽  
Author(s):  
Noriyuki SAKATAI ◽  
Jing MENG ◽  
Koji MLYAMOTO ◽  
Shigeo TAKEBAYASHI ◽  
Tatsuo FURUKAWA ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Biology ◽  
Nonenzymatic Glycation ◽  
Diabetic Macroangiopathy

scholarly journals Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance

2019 ◽  
Vol 20 (12) ◽  
pp. 3076 ◽  
Author(s):  
Candice Chapouly ◽  
Sarah Guimbal ◽  
Pierre-Louis Hollier ◽  
Marie-Ange Renault
Keyword(s):  
Hedgehog Signaling ◽  
Current Knowledge ◽  
Vascular Biology ◽  
Cerebrovascular Diseases ◽  
Future Research ◽  
Cellular Mechanisms ◽  
Vascular Integrity ◽  
Hh Signaling ◽  
Vessel Integrity

The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic role of the Hh ligands has been confirmed in adults, especially under pathologic conditions. More recently, the Hh signaling has been proposed to improve vascular integrity especially at the blood–brain barrier (BBB). However, molecular and cellular mechanisms underlying the role of the Hh signaling in vascular biology remain poorly understood and conflicting results have been reported. As a matter of fact, in several settings, it is currently not clear whether Hh ligands promote vessel integrity and quiescence or destabilize vessels to promote angiogenesis. The present review relates the current knowledge regarding the role of the Hh signaling in vasculature development, maturation and maintenance, discusses the underlying proposed mechanisms and highlights controversial data which may serve as a guideline for future research. Most importantly, fully understanding such mechanisms is critical for the development of safe and efficient therapies to target the Hh signaling in both cancer and cardiovascular/cerebrovascular diseases.

Vascular biology of thrombosis: The role of platelet-vessel wall adhesion

Neurology ◽  
2001 ◽  
Vol 57 (Supplement 2) ◽  
pp. S1-S4 ◽  
Author(s):  
D. J. Fitzgerald
Keyword(s):  
Vessel Wall ◽  
Vascular Biology

Vascular Biology

Stroke ◽  
2021 ◽  
Author(s):  
Nabil J. Alkayed ◽  
Marilyn J. Cipolla
Keyword(s):  
Vascular Biology ◽  
Collateral Flow ◽  
Cerebral Microcirculation ◽  
Flow Variability

The article summarizes recent studies investigating mechanisms of collateral flow variability in stroke and the role of pericytes in cerebral microcirculation and stroke.

scholarly journals Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology

Blood ◽  
2012 ◽  
Vol 119 (11) ◽  
pp. 2452-2457 ◽  
Author(s):  
Marie-Christine Bouton ◽  
Yacine Boulaftali ◽  
Benjamin Richard ◽  
Véronique Arocas ◽  
Jean-Baptiste Michel ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Vascular Biology ◽  
Cell Types ◽  
Plasminogen Activators ◽  
Key Factor ◽  
Nervous System Function ◽  
Heparan Sulfates ◽  
Protease Nexin ◽  
Deficient Mice

Abstract Serine protease inhibitors, termed serpins, are key regulators in many biologic events. Protease nexin-1 (PN-1) is a serpin that is barely detectable in plasma but found in many organs and produced by most cell types, including monocytes, platelets, and vascular cells. It has a large inhibition spectrum because it is the most efficient tissue inhibitor of thrombin but also a powerful inhibitor of plasminogen activators and plasmin. It has a high affinity for glycosaminoglycans, such as heparan sulfates, which potentiate its activity toward thrombin and target it to the pericellular space. PN-1 has been previously largely described as a crucial regulator of the proteolytic activity in nerves and of central and peripheral nervous system function. In contrast, little was known about its involvement in hemostasis and vascular biology. This article reviews recent data underlining its emerging role as a key factor in the responses of vessels to injury. Indeed, studies of PN-1–deficient mice have established important antithrombotic and antifibrinolytic properties of this serpin that have heretofore gone unrecognized. The roles of PN-1 in the areas of hemostasis and thrombosis summarized here provide insights that may allow the development of drugs and treatment strategies to prevent or limit thrombotic disorders.

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