Sex Steroids, Growth Hormone, Leptin and the Pubertal Growth Spurt

2009 ◽  
pp. 77-85 ◽  
Author(s):  
Alan D. Rogol
Keyword(s):  
Growth Hormone ◽  
Sex Steroids ◽  
Growth Spurt ◽  
Pubertal Growth Spurt ◽  
Pubertal Growth

scholarly journals The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt

2015 ◽  
Vol 82 (6) ◽  
pp. 862-869 ◽  
Author(s):  
T.J. Cole ◽  
M.L. Ahmed ◽  
M.A. Preece ◽  
P. Hindmarsh ◽  
D.B. Dunger
Keyword(s):  
Growth Factor ◽  
Sex Steroids ◽  
Growth Spurt ◽  
Insulin Like Growth Factor ◽  
Pubertal Growth Spurt ◽  
Pubertal Growth ◽  
The Relationship

scholarly journals Serum DHEA-S levels could be used as a comparable diagnostic test to assess the pubertal growth spurt in dentofacial orthopedics

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
V. Anusuya ◽  
Amit Nagar ◽  
Pradeep Tandon ◽  
G. K. Singh ◽  
Gyan Prakash Singh ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Growth Spurt ◽  
Pubertal Growth Spurt ◽  
Pubertal Growth ◽  
Dentofacial Orthopedics

Prepubertal urinary estrogen excretion and its relationship with pubertal timing

2010 ◽  
Vol 299 (6) ◽  
pp. E990-E997 ◽  
Author(s):  
Lijie Shi ◽  
Thomas Remer ◽  
Anette E. Buyken ◽  
Michaela F. Hartmann ◽  
Philipp Hoffmann ◽  
...  
Keyword(s):  
Pubertal Timing ◽  
Height Velocity ◽  
Breast Development ◽  
Growth Spurt ◽  
Age At Menarche ◽  
Healthy Children ◽  
Pubertal Growth Spurt ◽  
Peak Height Velocity ◽  
Pubertal Growth ◽  
Estrogen Production

Whether prepubertal estrogen production impacts on the timing of puberty is not clear. We aimed to investigate prepubertal 24-h estrogen excretion levels and their association with early and late pubertal markers. Daily urinary excretion rates of estrogens of 132 healthy children, who provided 24-h urine samples 1 and 2 yr before the start of the pubertal growth spurt [age at takeoff (ATO)], were quantified by stable isotope dilution/GC-MS. E-sum3 (estrone + estradiol + estriol) was used as a marker for potentially bioactive estrogen metabolites and E-sum5 (E-sum3 + 16-epiestriol + 16-ketoestradiol) for total estrogen production. Pubertal outcomes were ATO, age at peak height velocity (APHV), duration of pubertal growth acceleration (APHV-ATO), age at Tanner stage 2 for pubic hair (PH2), genital (G2, boys) and breast (B2, girls) development, and age at menarche. Prepubertal urinary estrogen excretions (E-sum3 and E-sum5) were not associated with ATO, APHV, and age at PH2 but with duration of pubertal growth acceleration ( P < 0.01) in both sexes. Girls with higher E-sum3 reached B2 0.9 yr ( P = 0.04) and menarche 0.3 yr earlier ( P = 0.04) than girls with lower E-sum3. E-sum3 was not associated with age at G2 in boys ( P = 0.6). For most pubertal variables, the associations with E-sum3 were stronger than with E-sum5. In conclusion, prepubertal estrogens may not be critical for the onset of the pubertal growth spurt but are correlated with its duration in both boys and girls. Prepubertal estrogen levels may already predict the timing of girls' menstruation and breast development but do not appear to affect sexual maturation in boys.

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