Protective Effects of the Angiotensin II Receptor Blocker Losartan on Cisplatin-Induced Kidney Injury

Chemotherapy ◽  
2009 ◽  
Vol 55 (6) ◽  
pp. 399-406 ◽  
Author(s):  
Samira Saleh ◽  
Afaf A. Ain-Shoka ◽  
Ebtehal El-Demerdash ◽  
Marwa M. Khalef
Keyword(s):  
Angiotensin Ii ◽  
Kidney Injury ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Protective Effects ◽  
Angiotensin Ii Receptor

Protective effects of the angiotensin II receptor blocker telmisartan on epirubicin-induced inflammation, oxidative stress, and early ventricular impairment

2010 ◽  
Vol 160 (3) ◽  
pp. 487.e1-487.e7 ◽  
Author(s):  
Christian Cadeddu ◽  
Alessandra Piras ◽  
Giovanni Mantovani ◽  
Martino Deidda ◽  
Mariele Dessì ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Protective Effects ◽  
Angiotensin Ii Receptor

scholarly journals Renin Inhibitor Aliskiren Improves Impaired Nitric Oxide Bioavailability and Protects Against Atherosclerotic Changes

Hypertension ◽  
2008 ◽  
Vol 52 (3) ◽  
pp. 563-572 ◽  
Author(s):  
Toshio Imanishi ◽  
Hiroto Tsujioka ◽  
Hideyuki Ikejima ◽  
Akio Kuroi ◽  
Shigeho Takarada ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renin Inhibitor ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Protective Effects ◽  
Angiotensin Ii Receptor ◽  
Plaque Area ◽  
Direct Renin Inhibitor ◽  
Valsartan Group ◽  
Atherosclerotic Changes

We investigated whether aliskiren, a direct renin inhibitor, improves NO bioavailability and protects against spontaneous atherosclerotic changes. We also examined the effects of cotreatment with aliskiren and valsartan, an angiotensin II receptor blocker, on the above-mentioned outcomes. Watanabe heritable hyperlipidemic rabbits were treated with vehicle (control), aliskiren, valsartan, or aliskiren plus valsartan for 8 weeks. Then, acetylcholine-induced NO production was measured as a surrogate index of endothelium protective function, and both superoxide and vascular peroxynitrite were measured. Tetrahydrobiopterin in aortic segments was assessed by high-performance liquid chromatography with fluorescence detection. Plaque area was quantified by histology. Increase in plasma NO concentration in response to intra-aortic acetylcholine infusion was significantly greater in all of the test groups than in controls. Aliskiren+valsartan cotreatment increased acetylcholine-induced NO by 6.2 nmol/L, which was significantly higher than that with either aliskiren or valsartan alone. Vascular superoxide and peroxynitrite levels were both significantly higher in controls and significantly lower in the aliskiren+valsartan group than in the aliskiren or valsartan group. The highest tetrahydrobiopterin levels were observed after aliskiren+valsartan cotreatment. Histology of the thoracic aorta revealed that the plaque area was significantly decreased with combination therapy compared with monotherapy. Treatment with a direct renin inhibitor has protective effects on endothelial function and atherosclerotic changes. Furthermore, cotreatment with a direct renin inhibitor and an angiotensin II receptor blocker has additive protective effects on both.

scholarly journals Efficacy and Mechanism of Angiotensin II Receptor Blocker Treatment in Experimental Abdominal Aortic Aneurysms

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e49642 ◽  
Author(s):  
Yasunori Iida ◽  
Baohui Xu ◽  
Geoffrey M. Schultz ◽  
Vinca Chow ◽  
Julie J. White ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Abdominal Aortic

911 A Novel Use of Angiotensin II Receptor Blocker (ARB) Losartan to Inhibit AOM Induced Tumorigenesis and Neoangiogenesis in Experimental Colon Cancer

2015 ◽  
Vol 148 (4) ◽  
pp. S-172 ◽  
Author(s):  
Vesta Valuckaite ◽  
Sarah Ruderman ◽  
Anas Almoghrabi ◽  
John Hart ◽  
Almaz Abdyrakov ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Angiotensin Ii ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor
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