scholarly journals Increased Serum Levels of Growth-Related Oncogene-α in Patients with Generalized Pustular Psoriasis

Dermatology ◽  
2010 ◽  
Vol 220 (1) ◽  
pp. 46-48 ◽  
Author(s):  
Yasunobu Kato ◽  
Toshiyuki Yamamoto
Keyword(s):  
Serum Levels ◽  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

scholarly journals A Case of Old Age-Onset Generalized Pustular Psoriasis with a Deficiency of IL-36RN (DITRA) Treated by Granulocyte and Monocyte Apheresis

2015 ◽  
Vol 7 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Chiharu Tominaga ◽  
Masaaki Yamamoto ◽  
Yasutomo Imai ◽  
Kiyofumi Yamanishi
Keyword(s):  
Receptor Antagonist ◽  
Dose Reduction ◽  
Old Age ◽  
Psoriasis Vulgaris ◽  
Serum Levels ◽  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis ◽  
Homozygous Mutations ◽  
Inflammatory Infiltrates

A 78-year-old woman who had been suffering from psoriasis vulgaris for 31 years was admitted to hospital because of her erythroderma. A toxic eruption was suspected and she was treated with prednisolone 30 mg daily. However, it was ineffective and, suspecting psoriatic erythroderma, cyclosporine 150 mg daily was administered with tapering of the prednisolone. Two weeks after a dose reduction of cyclosporine to 100 mg/day, erythroderma with widespread generalized pustules and fever developed. Histology of a biopsy revealed inflammatory infiltrates in the skin with a spongiform pustule of Kogoj, which was consistent with generalized pustular psoriasis (GPP). Her pustules improved with additional etretinate 20 mg/day, but the erythroderma persisted and she consulted us. Three sessions of granulocyte and monocyte apheresis once weekly were effective for her condition and decreased her serum levels of IL-6 and IL-8. She had homozygous mutations of c.[28C>T] in IL36RN which cause p.[Arg10Ter]. She is the oldest reported case of GPP with a deficiency of interleukin-36 receptor antagonist (DITRA), although GPP in DITRA has been suggested to usually occur in younger cases with no pre-existing psoriasis vulgaris.

14402 Serum levels of thymus and activation-regulated chemokine in patients with psoriasis: Higher in patients with generalized pustular psoriasis

2020 ◽  
Vol 83 (6) ◽  
pp. AB137
Author(s):  
Yurika Kawasaki ◽  
Masahiro Kamata ◽  
Mayumi Nagata ◽  
Saki Fukaya ◽  
Kotaro Hayashi ◽  
...  
Keyword(s):  
Serum Levels ◽  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

scholarly journals Serum Cytokines Correlated with The Disease Severity of Generalized Pustular Psoriasis

2013 ◽  
Vol 34 (3) ◽  
pp. 153-161 ◽  
Author(s):  
Masaaki Yamamoto ◽  
Yasutomo Imai ◽  
Yoshiko Sakaguchi ◽  
Takashi Haneda ◽  
Kiyofumi Yamanishi
Keyword(s):  
Serum Levels ◽  
Pustular Psoriasis ◽  
Clinical Markers ◽  
Serum Samples ◽  
Protein Levels ◽  
Serum Cytokines ◽  
Cell Counts ◽  
Severity Scores ◽  
Generalized Pustular Psoriasis ◽  
White Blood Cell Counts

To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 serum samples from 6 cases with GPP during the course of the disease. Serum levels of IL-4, IL-8, CXCL1 and CCL3 were positively correlated with the severity scores of GPP, white blood cell counts and serum C-reactive protein levels. Serum levels of IL-1β, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-γand VEGF showed strong positive correlations (r> 0.4,p< 0.01) with all those 3 clinical markers. Of those, IL-10 and IL-22 were significantly decreased after treatment in parallel with the GPP score and therefore those two serum cytokines might be useful to evaluate the efficacy of treatment for GPP.

Generalized pustular psoriasis

1979 ◽  
Vol 115 (10) ◽  
pp. 1215-1216 ◽  
Author(s):  
F. R. Murphy
Keyword(s):  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

An Examination of Generalized Pustular Psoriasis in Pregnancy Based on the Serum Cytokine Levels.

1999 ◽  
Vol 61 (2) ◽  
pp. 144-147
Author(s):  
Miyako KUDO ◽  
Yoshihiro UMEBAYASHI ◽  
Tomoe KOTSUJI ◽  
Fujio OTSUKA
Keyword(s):  
Pustular Psoriasis ◽  
Serum Cytokine ◽  
Cytokine Levels ◽  
Generalized Pustular Psoriasis ◽  
In Pregnancy

A Case of Postpartum Severe Generalized Pustular Psoriasis Treated with Infliximab

2013 ◽  
Vol 75 (6) ◽  
pp. 504-507
Author(s):  
Reiko TSUTSUMI ◽  
Koji ADACHI ◽  
Yuichi YOSHIDA ◽  
Osamu YAMAMOTO
Keyword(s):  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

Generalized Pustular Psoriasis during Pregnancy.

2001 ◽  
Vol 63 (3) ◽  
pp. 248-251 ◽  
Author(s):  
Tomomi NAKATANI ◽  
Minoru TAKATA ◽  
Shigeru KAWARA ◽  
Kiyoshi UCHIDA
Keyword(s):  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis
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