Diurnal Variation in Onset of Hemorrhagic Stroke Is Independent of Risk Factor Status: Takashima Stroke Registry

2010 ◽  
Vol 34 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Tanvir Chowdhury Turin ◽  
Yoshikuni Kita ◽  
Nahid Rumana ◽  
Naoyuki Takashima ◽  
Masaharu Ichikawa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Diurnal Variation ◽  
Hemorrhagic Stroke ◽  
Stroke Registry ◽  
Risk Factor Status

scholarly journals The comparison of traditional vascular risk factor between hemorrhagic and non-hemorrhagic stroke

2017 ◽  
Vol 8 (6) ◽  
pp. 5-8
Author(s):  
Rizaldy Taslim Pinzon ◽  
Rosa De Lima Renita Sanyasi ◽  
Andre Dharmawan Wijono
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Protective Factor ◽  
Hemorrhagic Stroke ◽  
Sample Size Calculation ◽  
Vascular Risk Factor ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Significance Level ◽  
Stroke Registry

Background: Understanding about risk factors of stroke based on its pathology is very important. Previous study about the vascular risk factors in patients with stroke in Indonesia is very limited.Aims and Objective: Measure the comparison between traditional vascular risk factors in patients with hemorrhagic stroke and non-hemorrhagic (ischemic) stroke.Materials and Methods: This was a nested case-control study using secondary data from electronic medical record and electronic stroke registry of Bethesda Hospital Yogyakarta Indonesia. The stroke was diagnosed with standard way by well-trained neurologist and confirmed with CT Scan. The traditional risk factors were defined systematically. We used Dupont Power and Sample Size calculation software and StatCal EpiInfo software with significance level 0,05.Result: The data of 200 subjects consisted of 100 patients with hemorrhagic stroke and 100 patients with non-hemorrhagic stroke. Hypertension was main vascular risk factor in both Group but it was more common in hemorrhagic stroke (OR: 2,528, 95% CI: 0,069 ; 0,316, p < 0,002). Dyslipidemia was a protective factor against hemorrhagic stroke (OR: 0,147, 95% CI: 1,415 ; 4,516, p < 0,001). Diabetes was more common in ischemic stroke compared with hemorrhagic stroke (68% and 32%) respectively.Conclusion: Hypertension, dyslipidemia, and diabetes were modifiable traditional vascular risk factors which significantly had effect on stroke. Asian Journal of Medical Sciences Vol.8(6) 2017 5-8

Stroke Case Fatality Shows Seasonal Variation Regardless of Risk Factor Status in a Japanese Population: 15-Year Results from the Takashima Stroke Registry

2009 ◽  
Vol 32 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Tanvir Chowdhury Turin ◽  
Yoshikuni Kita ◽  
Nahid Rumana ◽  
Yoshitaka Murakami ◽  
Masaharu Ichikawa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Seasonal Variation ◽  
Japanese Population ◽  
Case Fatality ◽  
Stroke Registry ◽  
Stroke Case ◽  
Risk Factor Status

Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry

2022 ◽  
Vol 240 ◽  
pp. 113908
Author(s):  
Andrew Fu Wah Ho ◽  
Mervyn Jun Rui Lim ◽  
Huili Zheng ◽  
Aloysius Sheng-Ting Leow ◽  
Benjamin Yong-Qiang Tan ◽  
...  
Keyword(s):  
Air Pollution ◽  
Hemorrhagic Stroke ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Stroke Registry ◽  
Case Crossover ◽  
Crossover Analysis

Is breathing our polluted air a risk factor for stroke?

2019 ◽  
Vol 14 (4) ◽  
pp. 340-350 ◽  
Author(s):  
Conrado J Estol
Keyword(s):  
Air Pollution ◽  
Risk Factor ◽  
Hemorrhagic Stroke ◽  
Preventive Measures ◽  
Geographical Location ◽  
Vascular Risk ◽  
Lipid Levels ◽  
Ample Evidence ◽  
Academy Of Sciences ◽  
Acute And Chronic Exposure

The conference “Climate change, air pollution and health” was held at the Pontifical Academy of Sciences. The data presented highlighted that air pollution is a major, under-recognized and modifiable risk factor for stroke and heart disease. Air pollution causes 7.6% of all deaths making it the fifth cause of death globally, and this figure is expected to increase by 50% by 2050. Particulate matter causes endothelial dysfunction and induces thrombosis by altering reactive oxygen species, nitric oxide, insulin resistance, and lipid levels. Thirty-three articles published since 2002 were reviewed to assess the relation between air pollution and stroke with age, geographical location, particulate and gaseous matter type, duration of exposure, previous stroke, and comorbidities. It remains to be defined if air pollution has pathophysiological effects that preferentially predispose individuals to ischemic or hemorrhagic stroke. There is ample evidence showing an association between acute and chronic exposure to PM2.5 or gaseous pollutants with stroke. This potentially avoidable scenario and its dramatic consequences are heavily under-recognized by health professionals and the wider public. Preventive measures in people at high vascular risk are warranted. Procrastination in implementing efforts to stop the current worldwide course of worsening air pollution is the seed of a potential global health catastrophe.

scholarly journals Risk factors and clinical outcomes in chronic coronary and peripheral artery disease: An analysis of the randomized, double-blind COMPASS trial

2019 ◽  
Vol 27 (3) ◽  
pp. 296-307 ◽  
Author(s):  
Thomas Vanassche ◽  
Peter Verhamme ◽  
Sonia S Anand ◽  
Olga Shestakovska ◽  
Keith AA Fox ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Peripheral Artery Disease ◽  
Low Dose ◽  
Cardiovascular Death ◽  
Peripheral Artery ◽  
Double Blind ◽  
Artery Disease ◽  
Risk Factor Status ◽  
Ischemic Events

Aims Secondary prevention in patients with coronary artery disease and peripheral artery disease involves antithrombotic therapy and optimal control of cardiovascular risk factors. In the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) study, adding low-dose rivaroxaban on top of aspirin lowered cardiovascular events, but there is limited data about risk factor control in secondary prevention. We studied the association between risk factor status and outcomes, and the impact of risk factor status on the treatment effect of rivaroxaban, in a large contemporary population of patients with coronary artery disease or peripheral artery disease. Methods and results We reported ischemic events (cardiovascular death, stroke, or myocardial infarction) in participants from the randomized, double-blind COMPASS study by individual risk factor (blood pressure, smoking status, cholesterol level, presence of diabetes, body mass index, and level of physical activity), and by number of risk factors. We compared rates and hazard ratios of patients treated with rivaroxaban plus aspirin vs aspirin alone within each risk factor category and tested for interaction between risk factor status and antithrombotic regimen. Complete baseline risk factor status was available in 27,117 (99%) patients. Status and number of risk factors were both associated with increased risk of ischemic events. Rates of ischemic events (hazard ratio 2.2; 95% confidence interval 1.8–2.6) and cardiovascular death (hazard ratio 2.0; 1.5–2.7) were more than twofold higher in patients with 4–6 compared with 0–1 risk factors ( p < 0.0001 for both). Rivaroxaban reduced event rates independently of the number of risk factors ( p interaction 0.93), with the largest absolute benefit in patients with the highest number of risk factors. Conclusion More favorable risk factor status and low-dose rivaroxaban were independently associated with lower risk of cardiovascular events.

scholarly journals Traffic-borne pollution as a risk factor for acute vascular events: a population study in Milan

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
P Magnoni ◽  
R Murtas ◽  
A G Russo
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Hemorrhagic Stroke ◽  
Proportional Hazards ◽  
Traffic Noise ◽  
Cox Proportional Hazards ◽  
Positive Trend ◽  
Traffic Intensity ◽  
Vascular Events ◽  
Remarkable Effect

Abstract Background Traffic-borne noise and air pollution have both been associated with cardiovascular and cerebrovascular diseases, albeit with inconsistent findings and issues of collinearity/mutual confounding. The present study aims at evaluating the role of long-term exposure to traffic-borne pollution as a risk factor for acute vascular events in a highly urbanized setting. Methods This is a population-based retrospective dynamic cohort study including all residents aged &gt;35 years in the municipality of Milan over the years 2011-2018 (N = 1087110). A noise predictive model and a NO2 land-use regression model were used to assign mean values of traffic noise at the day-evening-night level (Lden, dB) and NO2 concentration (µg/m3) to the residential address of each subject. Cox proportional hazards models were performed to assess the incidence of acute vascular events, with adjustment for potential confounders (age, sex, nationality, a socio-economic deprivation index) and sub-analyses for different outcomes (acute myocardial infarction, ischemic stroke, hemorrhagic stroke). Results A total of 27282 subjects (2.5%) had an acute vascular event. Models using NO2 yielded inconsistent results. When using Lden as a proxy of traffic intensity, there was a positive trend in risk with increasing levels of exposure, with an optimal cut-off for dichotomization set at 70 dB (HR 1.025, 95% C.I. 1.000-1.050). The association was observed specifically for ischemic stroke (HR 1.043, 95% C.I. 1.003-1.085) and hemorrhagic stroke (HR 1.036, 95% C.I. 0.969-1.107). When stratifying by age group and sex, a remarkable effect was found for hemorrhagic stroke in men aged &lt;60 (HR 1.439, 95% C.I. 1.156-1.792). Conclusions Living close to high-traffic roads was found to exert a small but tangible effect on the risk of stroke. The varying effects observed for specific outcomes and in different age and sex groups are likely due to different pathogenetic mechanisms at play, which warrant further investigation. Key messages Residential proximity to roads with high traffic intensity (mean traffic noise level over 70 dB) is a risk factor for stroke, especially for hemorrhagic stroke in middle-aged men. Further interventions aimed at reducing traffic intensity in highly urbanized cities may be justified in order to reduce morbidity and mortality from stroke.

scholarly journals Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Sintaroo Watanabe ◽  
Yuya Kawasaki ◽  
Kazuaki Kawai
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Diurnal Variation ◽  
Life Style ◽  
Oxidative Stress Marker ◽  
Diurnal Pattern ◽  
Average Amount ◽  
Stress Marker ◽  
Oxidative Stress Status ◽  
The Individual

Abstract Introduction Oxidative stress is a risk factor for life-style related diseases, including cancer. We recently reported that the oxidative stress marker 8-hydroxyguanine (8-OHGua) can be measured in saliva non-invasively. Understanding the diurnal pattern of salivary 8-OHGua levels is crucial for evaluating the oxidative stress. In this study, we analyzed the diurnal variation of salivary 8-OHGua levels. Findings The salivary 8-OHGua levels were relatively stable in the daytime (10:00–22:00). The daytime 8-OHGua levels seemed to represent the individual oxidative stress status. The average amount and the variation of the salivary 8-OHGua levels immediately after awakening were higher than those of the daytime levels. Conclusions The 8-OHGua levels in saliva exhibited diurnal variation. The levels were higher at the time of awakening. At this point, the daytime levels of salivary 8-OHGua may be appropriate for evaluating the individual oxidative stress status. Further study is needed for understanding and utilizing the 8-OHGua levels at the time of awakening.

scholarly journals Association between breast-feeding and anthropometry and CVD risk factor status in adolescence and young adulthood: the Young Hearts Project, Northern Ireland

2009 ◽  
Vol 13 (06) ◽  
pp. 771-778 ◽  
Author(s):  
Valerie A Holmes ◽  
Chris Cardwell ◽  
Michelle C McKinley ◽  
Ian S Young ◽  
Liam J Murray ◽  
...  
Keyword(s):  
Risk Factor ◽  
Northern Ireland ◽  
Young Adulthood ◽  
Breast Feeding ◽  
Cvd Risk ◽  
Adolescence And Young Adulthood ◽  
Risk Factor Status
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