Detection of Lymphovascular Invasion in Vulvar Cancer by D2-40 (Podoplanin) as a Predictor for Inguinal Lymph Node Metastases

Onkologie ◽  
2009 ◽  
Vol 32 (12) ◽  
pp. 732-738 ◽  
Author(s):  
Michael Braun ◽  
Eva Wardelmann ◽  
Manuel Debald ◽  
Gisela Walgenbach-Bruenagel ◽  
Tobias Höller ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Lymphovascular Invasion ◽  
Vulvar Cancer ◽  
Inguinal Lymph Node ◽  
Node Metastases

scholarly journals PD53-07 RISK OF INGUINAL LYMPH NODE METASTASES IN MEN WITH T1G2 PENILE CANCER STRATIFIED BY LYMPHOVASCULAR INVASION

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
Christian Fankhauser ◽  
Hielke M. de Vries ◽  
Eduard Roussel ◽  
Jakob Kristian Jakobsen ◽  
Allaudin Issa ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Penile Cancer ◽  
Lymphovascular Invasion ◽  
Inguinal Lymph Node ◽  
Node Metastases

Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases

2005 ◽  
Vol 96 (1) ◽  
pp. 227-231 ◽  
Author(s):  
Filippo Bellati ◽  
Roberto Angioli ◽  
Natalina Manci ◽  
Marzio Angelo Zullo ◽  
Ludovico Muzii ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Vulvar Cancer ◽  
Inguinal Lymph Node ◽  
Single Agent ◽  
Node Metastases

An Intriguing Case: Malignant Mesothelioma Presenting as Inguinal Lymph Node Metastases

2004 ◽  
Vol 28 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Judy A. C. King ◽  
Catherine M. Listinsky ◽  
J. Allan Tucker
Keyword(s):  
Lymph Node ◽  
Malignant Mesothelioma ◽  
Lymph Node Metastases ◽  
Inguinal Lymph Node ◽  
Node Metastases

Prognostic Role of Lymph Node Metastases in Vulvar Cancer and Implications for Adjuvant Treatment

2012 ◽  
Vol 22 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Linn Woelber ◽  
Christine Eulenburg ◽  
Matthias Choschzick ◽  
Andreas Kruell ◽  
Cordula Petersen ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adjuvant Treatment ◽  
Lymph Node Metastases ◽  
Adjuvant Radiotherapy ◽  
Vulvar Cancer ◽  
Disease Free Survival ◽  
Free Survival ◽  
Node Negative ◽  
Node Metastases ◽  
Disease Free

ObjectiveLymph node metastases are the most important prognostic factor for recurrence and survival in vulvar cancer. However, information regarding the impact of the number of positive nodes in vulvar cancer is inconsistent, and so are recommendations when to apply adjuvant radiotherapy.MethodsOne hundred fifty-seven consecutive patients with primary squamous cell cancer of the vulva treated at our center were analyzed. All patients underwent primary surgery by triple incision resulting in complete tumor resection.ResultsMedian age was 61 years; 49 patients (31%) had lymph node metastases; 21 patients had 1, 13 had 2, and 15 had more than 2 positive lymph nodes. Thirty-two percent of the patients received adjuvant radiotherapy. The risk of lymph node metastases increased with age, greater tumor size, deeper invasion, and higher tumor grade. Median follow-up was 36 months; 23 patients (14.6%) developed disease recurrence (61% vulva, 35% groins, and 4% both). Compared with node-negative patients, survival in all node-positive patients was significantly impaired (P < 0.001; disease-free patients after 2 years: 88% in node-negative patients; 60%, 43%, and 29% in patients with 1, 2, and >2 affected nodes, respectively), whereas no significant difference between the node-positive subgroups could be demonstrated regarding disease-free survival. In multivariate analysis, lymph node status remained the most important prognostic factor regarding disease-free survival, but the effect of positive nodes differed significantly dependent on adjuvant treatment (P = 0.001). In patients without adjuvant radiotherapy to the groins/pelvis, the number of metastatic nodes was highly relevant for prognosis (hazard ratio, 1.752; P < 0.001), whereas this effect disappeared in patients who were treated with adjuvant radiotherapy (hazard ratio, 0.972; P = 0.828).ConclusionsThe negative impact of lymph node metastases is already evident in patients with only 1 affected lymph node. In patients receiving adjuvant radiotherapy, the negative effect of additional lymph node metastases is reduced; adjuvant treatment might therefore be beneficial in patients with only 1 positive node.

MP11-04 CONTEMPORARY INCIDENCE AND PREDICTORS OF OCCULT INGUINAL LYMPH NODE METASTASES IN MEN WITH CN0 PENILE CANCER

2020 ◽  
Vol 203 ◽  
pp. e136
Author(s):  
Pooja Unadkat* ◽  
Aaron Fleishman ◽  
Aria Olumi ◽  
Andrew Wagner ◽  
Peter Chang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Penile Cancer ◽  
Inguinal Lymph Node ◽  
Node Metastases

scholarly journals A Case of Heterochronously Occurred Bilateral Inguinal Lymph Node Metastases of Unknown Origin.

2002 ◽  
Vol 63 (11) ◽  
pp. 2815-2819 ◽  
Author(s):  
Toru KIMURA ◽  
Hideki KANAZAWA ◽  
Yasuhiko NISHIYAMA ◽  
Goro KANEDA ◽  
Noriyoshi AKIYAMA ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Inguinal Lymph Node ◽  
Unknown Origin ◽  
Node Metastases

A Critical Assessment of Adjuvant Radiotherapy for Inguinal Lymph Node Metastases from Melanoma

2004 ◽  
Vol 11 (12) ◽  
pp. 1079-1084 ◽  
Author(s):  
Matthew T. Ballo ◽  
Gunar K. Zagars ◽  
Jeffrey E. Gershenwald ◽  
Jeffrey E. Lee ◽  
Paul F. Mansfield ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Adjuvant Radiotherapy ◽  
Inguinal Lymph Node ◽  
Critical Assessment ◽  
Node Metastases
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