Sweet’s Syndrome Simulating Systemic Lupus Erythematosus

Dermatology ◽  
1972 ◽  
Vol 144 (6) ◽  
pp. 321-324 ◽  
Author(s):  
Rida Frayha ◽  
Muna Matta ◽  
A. Kurban
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
J. L. Barton ◽  
L. Pincus ◽  
J. Yazdany ◽  
N. Richman ◽  
T. H. McCalmont ◽  
...  

Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.


Lupus ◽  
2009 ◽  
Vol 18 (4) ◽  
pp. 377-378 ◽  
Author(s):  
N Gollol-Raju ◽  
M Bravin ◽  
D Crittenden

2013 ◽  
Vol 40 (8) ◽  
pp. 641-648 ◽  
Author(s):  
Hideaki Tsuji ◽  
Hajime Yoshifuji ◽  
Ran Nakashima ◽  
Yoshitaka Imura ◽  
Naoichiro Yukawa ◽  
...  

Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.


2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI

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