Linear Localized Coumarin Necrosis

Dermatology ◽  
1984 ◽  
Vol 168 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Robert Allen Schwartz ◽  
Christopher Moore III ◽  
Clark Lambert
Keyword(s):  
1980 ◽  
Vol 116 (4) ◽  
pp. 444-445 ◽  
Author(s):  
S. M. Schleicher
Keyword(s):  

1982 ◽  
Vol 48 (03) ◽  
pp. 245-246 ◽  
Author(s):  
V Hofmann ◽  
P G Frick

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.


1973 ◽  
Vol 2 (2) ◽  
pp. 76-77 ◽  
Author(s):  
R. G. MOSES ◽  
J. R. WARREN
Keyword(s):  

1980 ◽  
Vol 116 (4) ◽  
pp. 444 ◽  
Author(s):  
Stephen M. Schleicher
Keyword(s):  

Author(s):  
Yavuz Harmanyeri ◽  
Oktay Taşkapan ◽  
Bilal Do?lan ◽  
Hüseyin Balo?lu ◽  
Mesut Başak
Keyword(s):  

1986 ◽  
Vol 14 (5) ◽  
pp. 797-802 ◽  
Author(s):  
Mary Seabury Stone ◽  
Ted Rosen
Keyword(s):  

1985 ◽  
Vol 60 (10) ◽  
pp. 673-674 ◽  
Author(s):  
Francis J. Kazmier
Keyword(s):  

1989 ◽  
Vol 141 (4) ◽  
pp. 946-948 ◽  
Author(s):  
Craig Barkley ◽  
Robert A. Badalament ◽  
Earl N. Metz ◽  
John Nesbitt ◽  
Joseph R. Drago
Keyword(s):  

VASA ◽  
2001 ◽  
Vol 30 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Hans-Jürgen Seyfarth ◽  
A. Siegemund ◽  
L. Helling ◽  
M. Woinke ◽  
D. Pfeiffer ◽  
...  

Die Cumarinnekrose ist eine seltene, aber klinisch bedeutsame Komplikation der Therapie mit Cumarinderivaten. Wir berichten über einen Patienten, der in der Einstellungsphase auf Phenprocoumon eine Cumarinnekrose erlitt. Als Ursache fand sich ein heterozygoter Protein S-Mangel vom Typ II. Anhand wichtiger Literaturdaten werden diagnostische Probleme und therapeutische Alternativen der Antikoagulation nach Cumarinnekrose diskutiert.


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