Solar Urticaria without Inhibitory Spectrum: Demonstration of Both Circulating Photoallergen and Reaginic Antibodies

Dermatology ◽  
1986 ◽  
Vol 173 (3) ◽  
pp. 116-119 ◽  
Author(s):  
Wakio Torinuki ◽  
Hachiro Tagami
Keyword(s):  
Solar Urticaria ◽  
Inhibitory Spectrum ◽  
Reaginic Antibodies

Solar urticaria

1979 ◽  
Vol 115 (6) ◽  
pp. 759-759 ◽  
Author(s):  
E. Van Hecke
Keyword(s):  
Solar Urticaria

scholarly journals Molecular Basis of AmpC β-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants

2021 ◽  
Vol 22 (6) ◽  
pp. 3051
Author(s):  
Silvia López-Argüello ◽  
María Montaner ◽  
Antonio Oliver ◽  
Bartolome Moya
Keyword(s):  
Time Course ◽  
Clinical Isolates ◽  
Live Cells ◽  
Cell Binding ◽  
Penicillin Binding Proteins ◽  
New Class ◽  
Inhibitory Spectrum ◽  
Mechanistic Basis ◽  
Outer Membrane Permeability ◽  
Strain Dependent

Avibactam belongs to the new class of diazabicyclooctane β-lactamase inhibitors. Its inhibitory spectrum includes class A, C and D enzymes, including P. aeruginosa AmpC. Nonetheless, recent reports have revealed strain-dependent avibactam AmpC induction. In the present work, we wanted to assess the mechanistic basis underlying AmpC induction and determine if derepressed PDC-X mutated enzymes from ceftazidime/avibactam-resistant clinical isolates were further inducible. We determined avibactam concentrations that half-maximally inhibited (IC50) bocillin FL binding. Inducer β-lactams were also studied as comparators. Live cells’ time-course penicillin-binding proteins (PBPs) occupancy of avibactam was studied. To assess the ampC induction capacity of avibactam and comparators, qRT-PCR was performed in wild-type PAO1, PBP4, triple PBP4, 5/6 and 7 knockout derivatives and two ceftazidime/avibactam-susceptible/resistant XDR clinical isolates belonging to the epidemic high-risk clone ST175. PBP4 inhibition was observed for avibactam and β-lactam comparators. Induction capacity was consistently correlated with PBP4 binding affinity. Outer membrane permeability-limited PBP4 binding was observed in the live cells’ assay. As expected, imipenem and cefoxitin showed strong induction in PAO1, especially for carbapenem; avibactam induction was conversely weaker. Overall, the inducer effect was less remarkable in ampC-derepressed mutants and nonetheless absent upon avibactam exposure in the clinical isolates harboring mutated AmpC variants and their parental strains.

Solar urticaria treated with intravenous immunoglobulins

2011 ◽  
Vol 65 (2) ◽  
pp. 336-340 ◽  
Author(s):  
Henri Adamski ◽  
Christophe Bedane ◽  
Annie Bonnevalle ◽  
Pierre Thomas ◽  
Jean-Louis Peyron ◽  
...  
Keyword(s):  
Intravenous Immunoglobulins ◽  
Solar Urticaria

Active Bronchial Anaphylaxis in the Rat

1974 ◽  
Vol 52 (6) ◽  
pp. 1114-1118 ◽  
Author(s):  
L. M. Stotland ◽  
N. N. Share
Keyword(s):  
Allergic Asthma ◽  
Specific Antigen ◽  
Female Rats ◽  
Sprague Dawley ◽  
Egg Albumin ◽  
Tracheal Pressure ◽  
Resultant Increase ◽  
Dose Responses ◽  
Reaginic Antibodies ◽  
Anaphylactic Response

Sprague–Dawley female rats were immunized with egg albumin (EA) in aluminum hydroxide gel (AHG) and with or without Bacillus pertussis vaccine (BPV). Fourteen days later, the animals were anesthetized and challenged with EA intravenously. The resultant increase in tracheal pressure was recorded as an index of anaphylactic bronchoconstriction. Ventilation with tracheal pressures of 6 cm H2O (588 N/m2) allowed maximal development of bronchoconstrictor responses to specific antigen challenge that were similar in both pithed and pentobarbital-anesthetized preparations. Forced reinflation of the lungs did not affect the magnitude of the response but did facilitate its recovery. Serum titers evaluated by 3-h and 72-h passive cutaneous anaphylactic reactions indicated that reaginic antibodies were primarily involved, although other immunoglobulins may have played a contributory role. Antigen dose-responses were similar for both the EA-AHG and EA-AHG-BPV immunized groups of animals despite lower reaginic serum titers for the former group. Thus, an immediate-type bronchial anaphylactic response mediated primarily by reaginic antibodies can be elicited in rats and quantitatively assessed. The potential immunologic similarity of these animals to human allergic asthma suggests their utility for further investigation.

scholarly journals Elevated blood histamine levels and mast cell degranulation in solar urticaria.

1980 ◽  
Vol 9 (2) ◽  
pp. 183-186 ◽  
Author(s):  
JL Hawk ◽  
RA Eady ◽  
AV Challoner ◽  
A. Kobza-Black ◽  
TM Keahey ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation ◽  
Elevated Blood ◽  
Solar Urticaria ◽  
Blood Histamine
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