Dysplastic Nevi and Germ Cell Tumors of the Testis – a Possible Further Tumor in the Spectrum of Associated Malignancies in Dysplastic Nevus Syndrome

Dermatology ◽  
1988 ◽  
Vol 176 (3) ◽  
pp. 109-110 ◽  
Author(s):  
Christian Sigg ◽  
Francesco Pelloni
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Dysplastic Nevus ◽  
Dysplastic Nevi ◽  
Dysplastic Nevus Syndrome

Lower Frequency of Sister Chromatid Exchanges and Altered Frequency of HLA B-region Alleles among Individuals with Sporadic Dysplastic Nevi

1997 ◽  
Vol 12 (3) ◽  
pp. 118-124
Author(s):  
M.T. Illeni ◽  
D. Rovini ◽  
M. Di Lernia ◽  
N. Cascinelli ◽  
A. Ghidoni
Keyword(s):  
Sister Chromatid ◽  
Hla Class I ◽  
Peripheral Blood Lymphocytes ◽  
Sister Chromatid Exchanges ◽  
Surgical Removal ◽  
Dysplastic Nevus ◽  
Dysplastic Nevi ◽  
Dysplastic Nevus Syndrome ◽  
Radiation Treatments ◽  
Chromatid Exchanges

Sister chromatid exchanges (SCE) were analyzed in peripheral blood lymphocytes of 24 individuals, following diagnosis, and prior to surgical removal, of a sporadic dysplastic nevus (DN). Lower SCE values and variability were found in 23 sporadic DN individuals compared with controls (2.52+0.12 and 3.76±0.22 SCE/cell, respectively). These DN individuals, contrarily to healthy controls and some types of tumor patients whose cells are hypersensitive to mutagenic agents, did not show increased SCE rates as a consequence of cigarette smoking, alcohol consumption and diagnostic radiation treatments. These observations are in contrast with clinical evidence that similar lesions are both markers or risk and precursors of malignancy in individuals with multiple nevi, affected by the dysplastic nevus syndrome (DNS) or belonging to FMM (familial malignant melanoma) families. Three HLA class I alleles out of 72 tested were found more frequently in sporadic DN individuals compared with controls: B37 (p<0.05), B52 (p<0.01) and B70 (p<0.01). Whether the greater chromosomal stability (as shown by the SCE analysis), and/or the altered frequency of some HLA alleles could influence the chance of developing cutaneous malignancy in DN individuals is yet to be evaluated.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

Chemotherapy for good-risk germ-cell tumors

2002 ◽  
Vol 20 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Charles J. Ryan ◽  
Dean F. Bajorin
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Good Risk

c-Kit gene mutations in intracranial germ cell tumors

2010 ◽  
Vol 222 (03) ◽  
Author(s):  
B Steiger ◽  
O Schmidt ◽  
T Pietsch
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Gene Mutations ◽  
Intracranial Germ Cell Tumors ◽  
Kit Gene

MR Imaging Findings of Pineal Germinoma: Focus on Differential Diagnosis from Other Germ Cell Tumors

1998 ◽  
Vol 39 (4) ◽  
pp. 639
Author(s):  
Hyun Jin Kim ◽  
Ho Kyu Lee ◽  
Jae Kyun Kim ◽  
Ji Hoon Shin ◽  
Choong Gon Choi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Imaging Findings ◽  
Pineal Germinoma

Sonographic Diagnosis of Unilateral Synchronous Testicular Tumors

2019 ◽  
Vol 2 ◽  
pp. 2
Author(s):  
Allison Forrest ◽  
Numbereye Numbere ◽  
Jerome Jean-Gilles ◽  
Thomas Frye ◽  
Vikram Dogra
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Histological Type ◽  
Synchronous Tumors ◽  
Testicular Tumors ◽  
Sonographic Diagnosis ◽  
Histological Types ◽  
Common Cancer

Testicular cancer accounts for 1% of all male cancers yet is the most common cancer affecting men aged 15–44 years. Most testicular cancers are seminomas or non-seminomatous germ cell tumors. Rarely, multiple testicular cancers may occur simultaneously, most often of the same histological type. However, synchronous tumors of different histological types may occur, although rarely. In this case study, we present the sonographic features with histopathologic correlation in a case of unilateral synchronous testicular tumors of discordant histology.

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