Staphylococcus aureus Skin Colonization in Infants with Atopic Dermatitis

Dermatology ◽  
1996 ◽  
Vol 193 (2) ◽  
pp. 83-87 ◽  
Author(s):  
G. Monti ◽  
P. Tonetto ◽  
M. Mostert ◽  
R. Oggero
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Skin Colonization

scholarly journals Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy

2017 ◽  
Vol 137 (12) ◽  
pp. 2497-2504 ◽  
Author(s):  
Patrick Meylan ◽  
Caroline Lang ◽  
Sophie Mermoud ◽  
Alexandre Johannsen ◽  
Sarah Norrenberg ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Clinical Diagnosis ◽  
Skin Colonization

scholarly journals Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

2020 ◽  
Vol 12 (551) ◽  
pp. eaay4068 ◽  
Author(s):  
Yuumi Nakamura ◽  
Hiroki Takahashi ◽  
Akiko Takaya ◽  
Yuzaburo Inoue ◽  
Yuki Katayama ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Quorum Sensing ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Whole Genome ◽  
Skin Colonization ◽  
Japanese Infants

Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus in the affected skin. To understand the role of S. aureus in the development of AD, we performed whole-genome sequencing of S. aureus strains isolated from the cheek skin of 268 Japanese infants 1 and 6 months after birth. About 45% of infants were colonized with S. aureus at 1 month regardless of AD outcome. In contrast, skin colonization by S. aureus at 6 months of age increased the risk of developing AD. Acquisition of dysfunctional mutations in the S. aureus Agr quorum-sensing (QS) system was primarily observed in strains from 6-month-old infants who did not develop AD. Expression of a functional Agr system in S. aureus was required for epidermal colonization and the induction of AD-like inflammation in mice. Thus, retention of functional S. aureus agr virulence during infancy is associated with pathogen skin colonization and the development of AD.

Staphylococcus aureus Skin Colonization in Atopic Dermatitis Patients

Dermatology ◽  
1985 ◽  
Vol 170 (1) ◽  
pp. 35-39 ◽  
Author(s):  
C. Hauser ◽  
B. Wuethrich ◽  
L. Matter ◽  
J.A. Wilhelm ◽  
W. Sonnabend ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Skin Colonization

scholarly journals THE FUNCTIONAL STATUS OF THE SKIN BARRIER IN CHILDREN WITH ATOPIC DERMATITIS

2013 ◽  
Vol 10 (1) ◽  
pp. 52-57
Author(s):  
E T Kindeeva ◽  
E E Varlamov ◽  
A N Pampura
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Topical Therapy ◽  
Skin Barrier ◽  
Specific Ige ◽  
Transepidermal Water Loss ◽  
Severe Atopic Dermatitis ◽  
Skin Ph ◽  
Skin Colonization

Introduction. One of the factors in the pathogenesis of atopic dermatitis is a dysfunction of the skin barrier. Background. To reveal the features of the barrier function of the skin in children with atopic dermatitis by measuring transepidermal water loss (TEWL) and the pH of the skin. Methods. The study included 98 children with atopic dermatitis. All patients measurement was performed by TEWL (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (Skin-pHMeter, Multi Probe Adapter MPA 5/9, Courage + Khazaka). Results. TEWL value was significantly higher in children with severe atopic dermatitis (p=0,00001), in children up to 3 years (p=0,002), in patients with skin colonization of Staphylococcus aureus (p=0,006) and with specific IgE to staphylococcal enterotoxins. Skin pH was significantly higher in children with severe atopic dermatitis (p=0,0001), and in children under the age of 3 years (p=0,04). Conclusion. The determination of the level of TEWL and skin pH to assess the degree of inflammation activity in atopic dermatitis and to justify use of topical therapy, aimed to restoring the epidermal barrier of the skin at children with atopic dermatitis, is substantiated.

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