BMP-7 Blocks the Cyclosporine-A-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells

2010 ◽  
Vol 114 (1) ◽  
pp. e23-e31 ◽  
Author(s):  
Yanfang Xu ◽  
Jianxin Wan ◽  
Dewen Jiang ◽  
Xiaonan Wu
Keyword(s):  
Epithelial Cells ◽  
Cyclosporine A ◽  
Epithelial To Mesenchymal Transition ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Mesenchymal Transition ◽  
Renal Tubular

Inhibitory Effect of Gliquidone on Epithelial-to-Mesenchymal-Transition of Renal Tubular Epithelial Cells Under Diabetic Nephropathy Mouse Model

2022 ◽  
Vol 12 (1) ◽  
pp. 71-80
Author(s):  
Ting Liu ◽  
Jie Chen ◽  
Yiying Ying ◽  
Ling Shi ◽  
Zhengyue Chen
Keyword(s):  
Diabetic Nephropathy ◽  
Epithelial Cells ◽  
Body Mass ◽  
Renal Fibrosis ◽  
Epithelial To Mesenchymal Transition ◽  
Inhibitory Effect ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Mesenchymal Transition ◽  
Renal Tubular

This research aimed to study the inhibitory effect of Glurenorm (gliquidone) on epithelial-to-mesenchymal-transition (EMT) of renal tubular epithelial cells based on the diabetic nephropathy (DN) model. In this study, 30 specific pathogen-free (SPF) mice were selected to construct DN model and randomly rolled into groups A, B, and C, with 10 mice in each group. Low-dose, mediumdose, and high-dose Glurenorm were administered intragastrically. The results showed that the serum urea nitrogen content (7.23±0.39 mmol/L, 6.18±0.46 mmol/L) of control and C group was considerably inferior to A group (8.01±0.48 mmol/L), and the content of C group was greatly lower than controls (P < 0.05). The creatinine clearance rate (2.97±0.44 mL/min, 4.02±0.31 mL/min) of mice in control and C group was notably superior to A group (2.18±0.38 mL/min), and that of C group was obviously higher versus controls (P < 0.05). After 5 weeks of intragastric intervention by Glurenorm, the body mass of the mice in control and C group was evidently lower relative to A group, and that of C group was obviously higher versus controls (P < 0.05). Mice in control and C group were remarkably lower in body mass at the 7th week after Glurenorm intervention versus A group, and C group was relatively lower versus controls (P < 0.05). In short, EMT played an important role in promoting the occurrence and progression of renal fibrosis. Glurenorm can reduce the progression of renal fibrosis, inhibit EMT of renal tubular epithelial cells, and effectively protect kidney function.

Sign in / Sign up

Export Citation Format

Share Document