Cerebral Hemodynamics and Oxygenation in Preterm Infants after Low- vs. High-Dose Surfactant Replacement Therapy

Neonatology ◽  
1993 ◽  
Vol 64 (4) ◽  
pp. 193-200 ◽  
Author(s):  
Caroline A. Dorrepaal ◽  
Manon J.N.L. Benders ◽  
Paul Steendijk ◽  
Margot van de Bor ◽  
Frank van Bel
Keyword(s):  
Replacement Therapy ◽  
Preterm Infants ◽  
Cerebral Hemodynamics ◽  
High Dose ◽  
Surfactant Replacement ◽  
Surfactant Replacement Therapy

Surfactant Replacement Therapy in Preterm Infants: A European Survey

Neonatology ◽  
2011 ◽  
Vol 100 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Anton H. van Kaam ◽  
Anne P. De Jaegere ◽  
Dorine Borensztajn ◽  
Peter C. Rimensberger
Keyword(s):  
Replacement Therapy ◽  
Preterm Infants ◽  
Surfactant Replacement ◽  
European Survey ◽  
Surfactant Replacement Therapy

Reintubation and risk of morbidity and mortality in preterm infants after surfactant replacement therapy

2011 ◽  
Vol 4 (2) ◽  
pp. 101-109 ◽  
Author(s):  
C.G. Guardia ◽  
F.R. Moya ◽  
S. Sinha ◽  
J. Gadzinowski ◽  
S.M. Donn ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Preterm Infants ◽  
Morbidity And Mortality ◽  
Surfactant Replacement ◽  
Surfactant Replacement Therapy

scholarly journals Evaluation of surfactant replacement therapy effects: A new potential role of lung ultrasound

2015 ◽  
Vol 143 (11-12) ◽  
pp. 669-675 ◽  
Author(s):  
Jovan Lovrenski ◽  
Erich Sorantin ◽  
Sanja Stojanovic ◽  
Aleksandra Doronjski ◽  
Aleksandra Lovrenski
Keyword(s):  
Replacement Therapy ◽  
Preterm Infants ◽  
Distress Syndrome ◽  
Lung Ultrasound ◽  
Grading System ◽  
Surfactant Replacement ◽  
Surfactant Replacement Therapy ◽  
Surfactant Administration ◽  
Us Findings

Introduction. Previous studies suggested that effects of the surfactant administration in preterm infants with respiratory distress syndrome cannot be followed by lung ultrasound (L-US). Objective. The aim of the paper is to evaluate the surfactant replacement therapy effects using a new, proposed grading system for L-US findings. Methods. We report the series of 12 preterm infants with clinical and radiographic signs of respiratory distress syndrome, in whom L-US examinations were performed prior to, and within the first 24 hours after surfactant administration. To evaluate the surfactant replacement therapy effects, we proposed a new grading system (1 to 6) for L-US findings at each examined lung area, based on the presence of normal finding, the amount of B-lines and subpleural consolidations. Results. All preterm infants had an improvement of L-US findings from one to four grades observed within the first 24 hours after surfactant administration, which has not been previously reported. The improvement of L-US findings was most commonly observed in anterior lung areas. Conclusion. L-US might enable an early detection of the surfactant replacement therapy effects. Further prospective studies are necessary to define the role of L-US in this field.

scholarly journals Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Robert Qaqish ◽  
Yui Watanabe ◽  
Marcos Galasso ◽  
Cara Summers ◽  
A adil Ali ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Lung Lavage ◽  
Post Injury ◽  
Surfactant Replacement ◽  
Recruitment Maneuvers ◽  
Surfactant Replacement Therapy ◽  
Dosing Strategies ◽  
Yorkshire Pigs ◽  
Saline Lavage ◽  
Protective Systems

Abstract Background There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems that become deranged in ARDS such as surfactant. Although results of surfactant replacement therapy (SRT) in ARDS have been mixed, questions remain incompletely answered regarding timing and dosing strategies of surfactant. Furthermore, there are only few truly clinically relevant ARDS models in the literature. The primary aim of our study was to create a clinically relevant, reproducible model of severe ARDS requiring extracorporeal membrane oxygenation (ECMO). Secondly, we sought to use this model as a platform to evaluate a bronchoscopic intervention that involved saline lavage and SRT. Methods Yorkshire pigs were tracheostomized and cannulated for veno-venous ECMO support, then subsequently given lung injury using gastric juice via bronchoscopy. Animals were randomized post-injury to either receive bronchoscopic saline lavage combined with SRT and recruitment maneuvers (treatment, n = 5) or recruitment maneuvers alone (control, n = 5) during ECMO. Results PaO2/FiO2 after aspiration injury was 62.6 ± 8 mmHg and 60.9 ± 9.6 mmHg in the control and treatment group, respectively (p = 0.95) satisfying criteria for severe ARDS. ECMO reversed the severe hypoxemia. After treatment with saline lavage and SRT during ECMO, lung physiologic and hemodynamic parameters were not significantly different between treatment and controls. Conclusions A clinically relevant severe ARDS pig model requiring ECMO was established. Bronchoscopic saline lavage and SRT during ECMO did not provide a significant physiologic benefit compared to controls.

Surfactant Replacement Therapy and the Prevalence of Acute Retinopathy of Prematurity

Neonatology ◽  
1992 ◽  
Vol 61 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Richard J. Tubman ◽  
Simon J. Rankin ◽  
Henry L. Halliday ◽  
Stewart S. Johnston
Keyword(s):  
Replacement Therapy ◽  
Retinopathy Of Prematurity ◽  
Surfactant Replacement ◽  
Surfactant Replacement Therapy
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