Placental Transfer of Free Fatty Acids: Importance of Fetal Albumin Concentration and Acid-Base Status

Neonatology ◽  
1993 ◽  
Vol 63 (5) ◽  
pp. 273-280 ◽  
Author(s):  
Terence Stephenson ◽  
Julie Stammers ◽  
David Hull
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Placental Transfer ◽  
Albumin Concentration ◽  
Acid Base ◽  
Acid Base Status

The Placental Transfer and Fetal Effects of Levobupivacaine, Racemic Bupivacaine, and Ropivacaine

1999 ◽  
Vol 90 (6) ◽  
pp. 1698-1703. ◽  
Author(s):  
Alan C. Santos ◽  
Barry Karpel ◽  
George Noble
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Local Anesthetics ◽  
Placental Transfer ◽  
Well Being ◽  
The Other ◽  
Uterine Blood Flow ◽  
Acid Base ◽  
Fetal Serum ◽  
Acid Base Status

Background The purposes of this study were to assess the effects of levobupivacaine on uterine blood flow and fetal well-being and to compare its placental transfer with that of bupivacaine and ropivacaine. Methods After a control period, pregnant ewes that were fitted with instruments for long-term monitoring were randomized to receive a two-step intravenous infusion of levobupivacaine, bupivacaine, or ropivacaine, in a blinded manner, for 1 h. Maternal and fetal hemodynamics were monitored during the study. Arterial blood samples were drawn at 30 and 60 min of infusion from the mother and fetus to determine the acid-base status (60 min only) and serum drug concentrations. The fetal brain, heart, liver, lungs, adrenal glands, and kidneys were obtained to measure tissue drug levels. Results Maternal blood pressure, central venous and intraamniotic pressures, acid-base status and uterine blood flow were unaffected by any drug infusion. In contrast to the other two local anesthetics, the infusion of bupivacaine was associated with a small but significant decrease in the ewe's heart rate. At the end of the study, the heart rate in the bupivacaine-treated animals was significantly less than in the animals treated with the other two drugs. All fetuses were in good condition at the start of study, and none of the local anesthetics affected fetal well-being. No significant differences were found among the three drugs in the maternal serum, fetal serum, fetal tissue concentrations, and tissue:serum concentration ratios. Conclusions Levobupivacaine was similar to bupivacaine and ropivacaine in causing no important hemodynamic changes in the pregnant ewe and fetus. There were no significant differences in the fetal serum and tissue levels of the drugs.

Concentrations of iodothyronines in serum of patients with chronic renal failure and other nonthyroidal illnesses: role of free fatty acids.

1987 ◽  
Vol 33 (8) ◽  
pp. 1382-1386 ◽  
Author(s):  
K Liewendahl ◽  
S Tikanoja ◽  
H Mähönen ◽  
T Helenius ◽  
M Välimäki ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Free Fatty Acids ◽  
Serum Proteins ◽  
Molar Ratio ◽  
Similar Degree ◽  
Albumin Concentration ◽  
The Mean ◽  
Mean Concentration

Abstract The mean concentration of free thyroxin (FT4) in serum, as determined by direct equilibrium dialysis, was decreased in patients with chronic renal failure (CRF) and increased in patients with various other nonthyroidal illnesses (NTI). The mean concentration of dialyzable free triiodothyronine (FT3) in serum was equally low in both groups of patients. Patients with CRF of various etiology but a similar degree of renal failure as estimated from serum creatinine assay had very similar concentrations of FT4 and FT3 in their serum. Mean thyroxin (T4) and triiodothyronine (T3) concentrations in serum were decreased in CRF and NTI, whereas the mean reverse-T3 concentration in serum was normal in CRF and increased in NTI. T4-binding globulin and albumin were markedly decreased in CRF and NTI; T4-binding prealbumin was increased in CRF and decreased in NTI. The mean concentration of nonesterified free fatty acids (FFA) in serum was increased in NTI but not in CRF. The weak, but significant, positive correlation observed between FT4 and FFA in serum (r = 0.34, P less than 0.01) in NTI indicates that the increase in serum FT4 in this group of patients could be an effect, at least in part, of FFA competing with T4 for binding sites on serum proteins. The stronger correlation detected between the serum FT4 concentration and the FFA/albumin molar ratio in serum (r = 0.60, P less than 0.001) demonstrates the importance of a low albumin concentration for expression of the effect of FFA on FT4 in severe systemic illnesses.

scholarly journals Comparison between bicarbonate-based and Stewart methods to assess metabolic acid-base disorders in internistic patients. A pilot study

2017 ◽  
Vol 5 (2) ◽  
pp. 234
Author(s):  
Valenti Maria ◽  
Bruno Francesca ◽  
Demma Shirin ◽  
Bruno Cosimo Marcello
Keyword(s):  
Metabolic Acidosis ◽  
Traditional Method ◽  
Metabolic Alkalosis ◽  
Metabolic Disorders ◽  
Albumin Concentration ◽  
Strong Ion Gap ◽  
Acid Base ◽  
Chi Square ◽  
Significant Difference ◽  
Acid Base Status

Aim: To assess the acid-base status in a cohort of internistic patients, using traditional and “modern” methods, to compare their different sensitivity to detect metabolic disorders and to evaluate a possible relationship between classical and alternative parameters.Patients and Methods: 143 assessment of acid-base and electrolytes balance on 121 internistic patients (76 males and 45 females, mean age 73.9 ± 10,8 years) were examined according to bicarbonate-based and Stewart methods.Results: The traditional method detected 81 cases (56.6 %) of metabolic alkalosis and 15 cases (10.4 %) of metabolic acidosis. The Stewart method detected 92 cases (64.3 %) of metabolic alkalosis and 22 cases (15.3%) of metabolic acidosis.Traditional method failed to detect 11 cases of metabolic alkalosis (chi square = 1.443; p = 0.226), and 7 cases of metabolic acidosis (chi square = 1.118; p = 0.290) when compared to Stewart's method. A significant relationship was observed between Strong Ion Gap (SIG) and Anion Gap corrected for albumin concentration (AGcorr) (r= 0.53; p <0.001).Conclusions: Our result showed that traditional method is useful to assess acid-base status in internistic clinical setting as well as Stewart's method because no significant difference was found between the two approaches. Nevertheless, the light disagreement observed between the two methods suggests that in a small percentage of cases the traditional method can fail to detect metabolic acid-base abnormalities.

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