A Prospective Study on the Development of Alzheimer’s Disease with Regard to Thyroid-Stimulating Hormone and Homocysteine

2009 ◽  
Vol 28 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Sylvia Annerbo ◽  
Miia Kivipelto ◽  
Johan Lökk
Keyword(s):  
Prospective Study ◽  
Thyroid Stimulating Hormone ◽  
A Prospective Study ◽  
Stimulating Hormone

scholarly journals Decrease of Free Thyroxine Levels after Controlled Ovarian Hyperstimulation1

2000 ◽  
Vol 85 (2) ◽  
pp. 545-548 ◽  
Author(s):  
A. F. Muller ◽  
A. Verhoeff ◽  
M. J. Mantel ◽  
F. H. de Jong ◽  
A. Berghout
Keyword(s):  
Controlled Ovarian Hyperstimulation ◽  
Thyroid Stimulating Hormone ◽  
Psychomotor Development ◽  
Ovarian Hyperstimulation ◽  
Free T4 ◽  
Before And After ◽  
Maternal Thyroid ◽  
A Prospective Study ◽  
Opposing Effects ◽  
Stimulating Hormone

Controlled ovarian hyperstimulation could lead to opposing effects on thyroid function. Therefore, in a prospective study of 65 women undergoing controlled ovarian hyperstimulation, thyroid hormones, T4-binding globulin, TPO antibodies, gonadotropins, estradiol, and PRL were measured before and after controlled ovarian hyperstimulation. After ovarian stimulation (mean ± se of mean): free T4 decreased, 14.4 ± 0.2 vs. 12.9 ± 0.2 pmol/L (P < 0.0001); thyroid-stimulating hormone increased, 2.3 ± 0.3 vs. 3.0 ± 0.4 mU/L (P < 0.0001); T4-binding globulin increased, 25.2 ± 0.7 vs. 33.9 ± 0.9 mg/L (P < 0.0001); total T4 increased, 98.1 ± 2.3 vs. 114.6 ± 2.5 nmol/L (P < 0.0001); total T3 increased, 2.0 ± 0.04 vs. 2.3 ± 0.07 nmol/L (P < 0.0001); TPO antibodies decreased, 370 ± 233 U/mL vs. 355 ± 224 U/mL (P < 0.0001); LH decreased, 8.1 ± 1.1 vs. 0.4 ± 0.1 U/L (P < 0.0001); FSH did not change, 6.5± 0.6 vs. 7.9 ± 0.9 U/L (P = 0.08); human CG increased, <2 ± 0.0 vs. 195 ± 16 U/L (P < 0.0001); estradiol increased, 359.3 ± 25.9 pmol/L vs. 3491.8 ± 298.3 pmol/L (P < 0.0001); and PRL increased, 0.23 ± 0.02 vs. 0.95 ± 0.06 U/L (P < 0.0001). Because low maternal free T4 and elevated maternal thyroid-stimulating hormone levels during early gestation have been reported to be associated with impaired psychomotor development in the offspring, our findings indicate the need for additional studies in the children of women who where exposed to high levels of estrogens around the time of conception.

Automated Requests for Thyroid-Stimulating Hormone and Ferretin Tests in Young Primary Care Patients with Anorexia as an Intervention to Improve Detection of Underlying Conditions

2019 ◽  
Vol 50 (3) ◽  
pp. 268-272 ◽  
Author(s):  
Maria Salinas ◽  
Maite López-Garrigós ◽  
Emilio Flores ◽  
Carlos Leiva-Salinas
Keyword(s):  
Primary Care ◽  
Clinical Laboratory ◽  
Demographic Data ◽  
Young Patients ◽  
Information Management System ◽  
Thyroid Stimulating Hormone ◽  
Primary Care Patients ◽  
A Prospective Study ◽  
Laboratory Information Management ◽  
Stimulating Hormone

Abstract Objective To improve clinical laboratory contribution to the treatment of primary care patients with anorexia through automated computerized strategies. Methods We recorded the number of laboratory requests due to anorexia; the demographic data, laboratory values, and presence of pathological values for the applicable patients. In a prospective study, the laboratory information management system (LIMS) automatically added thyroid-stimulating hormone (TSH) and/or ferritin testing when it was not requested by general practitioners for all primary care patients with anorexia who were younger than 16 years. Results A total of 3562 patients underwent laboratory testing due to anorexia, of whom 47% were younger than 16 years. The tests in which the results most frequently were abnormal were hemoglobin, ferritin, and TSH. TSH results were abnormal in 20% of patients younger than 16 years. Through the intervention, we detected 3 low ferritin values and 7 cases of pathological TSH levels. Conclusions The LIMS required TSH and ferritin testing in young patients even when not requested, potentially avoiding the adverse effects of iron deficiency and thyroid disorders on neurological development and cognition in those patients.

A prospective study of the effects of lithium on thyroid function and on the prevalence of antithyroid antibodies

1985 ◽  
Vol 15 (1) ◽  
pp. 55-61 ◽  
Author(s):  
D. H. Myers ◽  
R. A. Carter ◽  
B. H. Burns ◽  
A. Armond ◽  
S. B. Hussain ◽  
...  
Keyword(s):  
Prospective Study ◽  
Antibody Titre ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Thyroid Autoantibodies ◽  
Trh Test ◽  
Significant Difference ◽  
Free Thyroxine Index ◽  
A Prospective Study

SynopsisTests of thyroid function and pathology were carried out on 133 patients before they were treated with lithium (Li+). Of the 12 patients who subsequently became hypothyroid during treatment with lithium 9 had, before the commencement of treatment, thyroid autoantibodies and/or an exaggerated thyroid stimulating hormone (TSH) response to thyrotropin releasing hormone (TRH), whereas 3 patients had neither of these indicators. Lithium administration was accompanied by a rise in thyroid antibody titre in 20 patients but a fall in only 5, a statistically significant difference. Evidence that it may be an immunostimulant is discussed. Li+-induced thyroid failure cannot be accurately predicted, and may occur suddenly. The best minimum safeguard, therefore, is serial thyroxine (T4) (or free T4) estimation, supplemented if equivocal by a free thyroxine index (FTI), a basal TSH and, if doubt remains, by a TRH test.

Anxiety, depression and stressful life events among medical students: a prospective study in Antalya, Turkey

2001 ◽  
Vol 35 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Mehmet Aktekin ◽  
Taha Karaman ◽  
Yesim Yigiter Senol ◽  
Sukru Erdem ◽  
Hakan Erengin ◽  
...  
Keyword(s):  
Medical Students ◽  
Prospective Study ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
A Prospective Study ◽  
Anxiety Depression
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