Hepatic Cellular Development in the Rabbit

Neonatology ◽  
1981 ◽  
Vol 40 (3-4) ◽  
pp. 204-208 ◽  
Author(s):  
R.D.G. Milner ◽  
L. Pownall
Keyword(s):  
Cellular Development

scholarly journals CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis

2021 ◽  
Vol 22 (5) ◽  
pp. 2233
Author(s):  
Jilly Frances Evans ◽  
Kseniya Obraztsova ◽  
Susan M. Lin ◽  
Vera P. Krymskaya
Keyword(s):  
Integration Site ◽  
Cancer Development ◽  
Mechanistic Target Of Rapamycin ◽  
Complex Interactions ◽  
Signal Transduction Networks ◽  
Evolutionarily Conserved ◽  
Future Potential ◽  
Cellular Development ◽  
Wnt Signal ◽  
Disease Focus

The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments.

A model for cellular development in morphogenetic fields

1992 ◽  
pp. 351-370 ◽  
Author(s):  
Martin J. M. de Boer ◽  
F. David Fracchia ◽  
Przemyslaw Prusinkiewicz
Keyword(s):  
Cellular Development ◽  
Morphogenetic Fields

scholarly journals Cellular development in muscle differs between Angus steers from low and high muscle score selection lines1

2019 ◽  
Vol 97 (8) ◽  
pp. 3199-3212
Author(s):  
Paul L Greenwood ◽  
Brendon A O’Rourke ◽  
Joe Brunner ◽  
William H Johns ◽  
Paul F Arthur ◽  
...  
Keyword(s):  
Total Protein ◽  
Principal Component ◽  
Sectional Area ◽  
Loss Of Function ◽  
Cross Sectional ◽  
Longissimus Lumborum ◽  
Cellular Development ◽  
Selection For ◽  
Line P

Abstract This study assessed cellular characteristics of longissimus lumborum (LL) and semitendinosus (ST) muscles in steers genetically selected for low (Low) or high (High) muscling using live muscle scoring, and High steers with 1 copy of the loss-of-function 821 del11 MSTN allele (HighHet). We hypothesized High and HighHet have altered muscle cellular characteristics and mechanisms influencing muscling compared with Low steers. Angus steers 25 mo old comprising 14 High, 19 Low, and 11 HighHet were backgrounded to 20 mo of age, grain finished for 150 d, and then slaughtered. Body and carcass weights did not differ due to muscling line (P = 0.46). Weight of LL was 16% greater (P = 0.004) and total protein in LL was 18% greater (P = 0.012) in HighHet than Low steers. ST weight in HighHet was 10% and 13% greater than in High and Low steers (P = 0.007), respectively, and of total ST protein 12% and 17% greater in HighHet than High or Low (P = 0.002). Cross-sectional area (CSA) of LL was greater in HighHet than in High and greater in High than in Low (85.0 vs. 77.0 vs. 70.4 cm2, P < 0.001). Apparent number of myofibers and myofibers per unit CSA did not differ between the muscling lines in LL (P = 0.14) or ST (P = 0.47). Myofiber CSA was greater in the ST of Low than of High and HighHet for type 1 (36% and 31% respectively, P = 0.005) and 2A (22% and 25%, P < 0.001). HighHet steers had greater area of glycolytic (type 2X) relative to more oxidative myofiber types within LL (P = 0.02; 11% and 43% more than High and Low, respectively) and ST (P < 0.001; 27% and 75%). Concentration of RNA in LL was 13% and 10% greater (P = 0.005) in High than in Low and HighHet, respectively, and total amount of RNA in LL was 22% greater in High and 20% greater in HighHet than in Low (P < 0.001). The LL of High steers had less protein to RNA (P = 0.03; 57.4 vs. 65.6) and more RNA to DNA (P = 0.007; 9.03 vs. 7.83) than Low. HighHet steers had 11% more DNA in ST than High (P = 0.04) and 19% more RNA in ST than Low (P = 0.012). The shift towards glycolytic myofibers was consistent with loadings in a principal component that explained 39% of the variation in LL and 38% in ST. Overall, these findings show that selection for increased muscling using live cattle muscle scoring, and 1 copy of the 821 del11 MSTN allele, results in more glycolytic muscle. They also suggest that increased muscling of the High compared with Low steers may be associated with increased translational capacity in the LL.

Sign in / Sign up

Export Citation Format

Share Document