Total Glycosylated Hemoglobin in Mothers of Large-for-Gestational-Age Infants: A Postpartum Test for Undetected Maternal Diabetes?

Neonatology ◽  
1981 ◽  
Vol 40 (3-4) ◽  
pp. 129-135 ◽  
Author(s):  
Arnold Pollak ◽  
Roland Brehm ◽  
Liselotte Havelec ◽  
Gert Lubec ◽  
A. Malamitsi-Puchner ◽  
...  
Keyword(s):  
Gestational Age ◽  
Glycosylated Hemoglobin ◽  
Maternal Diabetes ◽  
Large For Gestational Age

scholarly journals Association between maternal diabetes, being large for gestational age and breast-feeding on being overweight or obese in childhood

Diabetologia ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Padma Kaul ◽  
Samantha L. Bowker ◽  
Anamaria Savu ◽  
Roseanne O. Yeung ◽  
Lois E. Donovan ◽  
...  
Keyword(s):  
Breast Feeding ◽  
Gestational Age ◽  
Maternal Diabetes ◽  
Large For Gestational Age

scholarly journals Risk factors for congenital hypothyroidism: results of a population case-control study (1997–2003)

2005 ◽  
Vol 153 (6) ◽  
pp. 765-773 ◽  
Author(s):  
Emanuela Medda ◽  
Antonella Olivieri ◽  
Maria Antonietta Stazi ◽  
Michele E Grandolfo ◽  
Cristina Fazzini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Hypothyroidism ◽  
Gestational Age ◽  
Case Control Study ◽  
Female Gender ◽  
Maternal Diabetes ◽  
Case Control ◽  
Large For Gestational Age ◽  
Increased Risk ◽  
Control Study

Objective: To identify risk factors for permanent and transient congenital hypothyroidism (CH). Design: A population-based case-control study was carried out by using the network created in Italy for the National Register of Infants with CH. Methods: Four controls were enrolled for each new CH infant; 173 cases and 690 controls were enrolled in 4 years. In order to distinguish among risk factors for permanent and transient CH, diagnosis was re-evaluated 3 years after enrolment when there was a suspicion of transient CH being present. Familial, maternal, neonatal and environmental influences were investigated. Results: An increased risk for permanent CH was detected in twins by a multivariate analysis (odds ratio (OR) = 12.2, 95% confidence interval (CI): 2.4–62.3). A statistically significant association with additional birth defects, female gender and gestational age >40 weeks was also confirmed. Although not significant, an increased risk of CH was observed among infants with a family history of thyroid diseases among parents (OR = 1.9, 95% CI: 0.7–5.2). Maternal diabetes was also found to be slightly associated with permanent CH (OR = 15.7, 95% CI: 0.9–523) in infants who were large for gestational age. With regard to transient CH, intrauterine growth retardation and preterm delivery were independent risk factors for this form of CH. Conclusion: This study showed that many risk factors contribute to the aetiology of CH. In particular, our results suggested a multifactorial origin of CH in which genetic and environmental factors play a role in the development of the disease.

Adipokines in umbilical cord blood from children born large for gestational age

2016 ◽  
Vol 29 (1) ◽  
Author(s):  
Ulrik Lausten-Thomsen ◽  
Michael Christiansen ◽  
Paula Louise Hedley ◽  
Jens-Christian Holm ◽  
Kjeld Schmiegelow
Keyword(s):  
Childhood Obesity ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Maternal Diabetes ◽  
Large For Gestational Age ◽  
Intrauterine Environment ◽  
Appropriate For Gestational Age ◽  
Commercial Kits

AbstractThe etiology of childhood obesity and the associated morbidity is multifactorial. Recently, data suggesting a prenatal programming towards later childhood obesity and metabolic deregulation through the intrauterine environment has emerged. This study explored the concentrations of adipokines and their mutual relationship at birth in children born to non-diabetic mothers.Adiponectin, leptin and sOB-R were measured using ELISA-based commercial kits in umbilical cord blood from 60 neonates (30 born large for gestational age [LGA] and 30 born appropriate for gestational age [AGA]). Children exposed to maternal diabetes, chronic disease and preeclampsia were excluded.The LGA group exhibited significantly elevated concentrations of leptin (p<0.001) and of free leptin index (p<0.001) and decreased sOB-R concentrations (p=0.005) when compared to the AGA group, which persisted in multiple regression analysis after taking the gestational age into account (p=0.048, p<0.001 and p<0.001, respectively). Only a trend towards a difference in adiponectin was demonstrated (p=0.057) regardless of adjustment (p=0.150). However, the leptin/adiponectin ratio was elevated in the LGA group (p=0.008), regardless of adjustment (p=0.039).The data indicate a disturbance of adipokines in macrosomic newborns and that the mutual ratios between adipokines may provide a more sensitive marker of metabolic disturbance than any isolated adipokine.

Postpartum glycosylated hemoglobin levels in mothers of large-for-gestational age infants

1980 ◽  
Vol 136 (3) ◽  
pp. 380-382 ◽  
Author(s):  
Ronald W. Coen ◽  
Richard Porreco ◽  
Larry Cousins ◽  
Jeffrey A. Sandler
Keyword(s):  
Gestational Age ◽  
Glycosylated Hemoglobin ◽  
Large For Gestational Age

Abstract #91: Comparison of Cord Blood Insulin in Large-for-Gestational-Age Infants and Appropriate-for-Age Filipino Infants of Nondiabetic Mothers: A Pilot Study

2004 ◽  
Vol 10 ◽  
pp. 31
Author(s):  
Florence M. Amorado-Santos ◽  
Maria Honolina S. Gomez ◽  
Maria Victoria R. Olivares ◽  
Zayda N. Gamilla
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Blood Insulin
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