Skin Barrier Properties in the Newborn

Neonatology ◽  
1977 ◽  
Vol 32 (3-4) ◽  
pp. 177-182 ◽  
Author(s):  
Robert L. Cunico ◽  
Howard I. Maibach ◽  
Hazoor Khan ◽  
Ernest Bloom
Keyword(s):  
Skin Barrier ◽  
Barrier Properties

Changes in corneocyte element concentrations occur in skin inner stratum corneum

1990 ◽  
Vol 48 (2) ◽  
pp. 146-147
Author(s):  
R. R. Warner
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Element Concentration ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Brick Wall ◽  
Inorganic Elements ◽  
Dry Skin ◽  
Skin Biopsies ◽  
Intercellular Lipid

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.

Short-Chain Ceramides Decrease Skin Barrier Properties

2009 ◽  
Vol 22 (1) ◽  
pp. 22-30 ◽  
Author(s):  
J. Novotný ◽  
B. Janůšová ◽  
M. Novotný ◽  
A. Hrabálek ◽  
K. Vávrová
Keyword(s):  
Skin Barrier ◽  
Barrier Properties ◽  
Short Chain

scholarly journals Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 684 ◽  
Author(s):  
Christian Gorzelanny ◽  
Christian Mess ◽  
Stefan W. Schneider ◽  
Volker Huck ◽  
Johanna M. Brandner
Keyword(s):  
Drug Delivery ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Multiphoton Microscopy ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Transepidermal Water Loss ◽  
Hair Follicles

Although, drugs are required in the various skin compartments such as viable epidermis, dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the skin is still challenging. An improved understanding of skin barrier physiology is mandatory to optimize drug penetration and permeation. The various barriers of the skin have to be known in detail, which means methods are needed to measure their functionality and outside-in or inside-out passage of molecules through the various barriers. In this review, we summarize our current knowledge about mechanical barriers, i.e., stratum corneum and tight junctions, in interfollicular epidermis, hair follicles and glands. Furthermore, we discuss the barrier properties of the basement membrane and dermal blood vessels. Barrier alterations found in skin of patients with atopic dermatitis are described. Finally, we critically compare the up-to-date applicability of several physical, biochemical and microscopic methods such as transepidermal water loss, impedance spectroscopy, Raman spectroscopy, immunohistochemical stainings, optical coherence microscopy and multiphoton microscopy to distinctly address the different barriers and to measure permeation through these barriers in vitro and in vivo.

Skin Barrier Properties in Different Body Areas in Neonates

PEDIATRICS ◽  
2000 ◽  
Vol 106 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Gil Yosipovitch ◽  
Ayala Maayan-Metzger ◽  
Paul Merlob ◽  
Lea Sirota
Keyword(s):  
Skin Barrier ◽  
Barrier Properties

The Influence of a Non-Occlusive Bi-Layer Composite Membrane on Skin Barrier Properties

2008 ◽  
Vol 21 (1) ◽  
pp. 50-55 ◽  
Author(s):  
V. Brazzelli ◽  
E. Berardesca ◽  
C. Rona ◽  
G. Borroni
Keyword(s):  
Composite Membrane ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Layer Composite

Human β-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis

2013 ◽  
Vol 169 (3) ◽  
pp. 587-593 ◽  
Author(s):  
M.-L. Clausen ◽  
J.M. Jungersted ◽  
P.S. Andersen ◽  
H.-C. Slotved ◽  
K.A. Krogfelt ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Skin Barrier ◽  
Barrier Properties
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