A Study of the Permeability of the Guinea Pig Placenta to Citrate Using Recirculating Placental Perfusion Technique

Neonatology ◽  
1976 ◽  
Vol 29 (5-6) ◽  
pp. 299-305 ◽  
Author(s):  
Enid Fenton ◽  
H.G. Britton ◽  
D.A. Nixon †
Keyword(s):  
Guinea Pig ◽  
Perfusion Technique ◽  
Placental Perfusion ◽  
Guinea Pig Placenta ◽  
Pig Placenta

PLACENTAL TRANSFER OF 131I-LABELLED IODIDE IN THE GUINEA-PIG

1964 ◽  
Vol 28 (3) ◽  
pp. 247-252 ◽  
Author(s):  
W. T. LONDON ◽  
W. L. MONEY ◽  
R. W. RAWSON
Keyword(s):  
Guinea Pig ◽  
Placental Transfer ◽  
Sodium Thiocyanate ◽  
Perfusion Technique ◽  
Maternal Circulation ◽  
Guinea Pig Placenta ◽  
Small Discharge ◽  
High Concentrations ◽  
Pig Placenta

SUMMARY The transfer of radioactive iodide (131I) across the guinea-pig placenta has been investigated, using an in situ perfusion technique. From these studies, it can be concluded that iodide is actively transported from the maternal side to the foetal side of the placenta, and is concentrated on the foetal side. Radio-iodide accumulates on the foetal side because the foetal placenta concentrates iodide from the maternal circulation and transfers little to the maternal circulation. High concentrations of stable iodide perfused on the foetal side did not affect the transfer of radio-iodide from the maternal circulation to the foetal side of the placenta. Sodium thiocyanate, on the other hand, blocked the concentration of iodide on the foetal side, and caused a small discharge of radio-iodide from the placenta.

Placental calcium and phosphorus transfer in the guinea pig: lack of effect of modulators of Ca-ATPase and alkaline phosphatase activity

1983 ◽  
Vol 61 (11) ◽  
pp. 1354-1360 ◽  
Author(s):  
H. G. McKercher ◽  
L. O. Derewlany ◽  
I. C. Radde
Keyword(s):  
Alkaline Phosphatase ◽  
Guinea Pig ◽  
Placental Transfer ◽  
Placental Perfusion ◽  
Perfusion Solution ◽  
Guinea Pig Placenta ◽  
Calcium And Phosphorus ◽  
Pig Placenta

The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into the mother (1.0 or 10.0 mg∙kg−1) or added to the solution perfusing the fetal side of the placenta (0.25 or 2.0 mM). These two drugs have previously been shown to inhibit placental Ca-ATPase and enhance AP activity in vitro. D-Penicillamine, which inhibits placental AP but not Ca-ATPase activity in vitro, also had no significant effect on net calcium and phosphorus transfer from mother to fetus either when given to the mother (50 mg∙kg−1) or added to the placental perfusion solution (0.25 or 2.0 mM). These results suggest that placental transfer of calcium and phosphorus in the guinea pig may not be directly related to placental Ca-ATPase and AP activities.

Transfer of lipids across the guinea pig placenta

1969 ◽  
Vol 104 (4) ◽  
pp. 564-572 ◽  
Author(s):  
Herbert J. Kayden ◽  
Joseph Dancis ◽  
William L. Money
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Placenta ◽  
Pig Placenta

Molecular charge effects on the protein permeability of the guinea-pig placenta

Placenta ◽  
1987 ◽  
Vol 8 (4) ◽  
pp. 365-380 ◽  
Author(s):  
A. Berhe ◽  
W.G. Bardsley ◽  
A. Harkes ◽  
C.P. Sibley
Keyword(s):  
Guinea Pig ◽  
Charge Effects ◽  
Guinea Pig Placenta ◽  
Molecular Charge ◽  
Pig Placenta ◽  
Protein Permeability
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