Regulation of Enzyme Development for Glycerol Utilization by Neonatal Rat Liver

Neonatology ◽  
1973 ◽  
Vol 23 (5-6) ◽  
pp. 403-413 ◽  
Author(s):  
Jane Ward ◽  
D.G. Walker
Keyword(s):  
Rat Liver ◽  
Neonatal Rat ◽  
Enzyme Development ◽  
Glycerol Utilization

scholarly journals Factors affecting the premature induction of phosphopyruvate carboxylase in neonatal rat liver

1968 ◽  
Vol 108 (2) ◽  
pp. 325-331 ◽  
Author(s):  
D. Yeung ◽  
I. T. Oliver
Keyword(s):  
Rat Liver ◽  
Actinomycin D ◽  
Blood Glucose Concentration ◽  
Enzyme Synthesis ◽  
Neonatal Rat ◽  
Carboxylase Activity ◽  
Factors Affecting ◽  
Glucose Injection ◽  
Enzyme Development ◽  
Amino Acid Analogues

1. Phosphopyruvate carboxylase activity rapidly appears in the liver of prematurely delivered rats and development of activity is prevented by injection of actinomycin D just before delivery. 2. The activity is considerably decreased by puromycin and amino acid analogues and thus appears to be due to enzyme synthesis. 3. Newborn or premature animals show a transient intense phase of hypoglycaemia after delivery. 4. When the hypoglycaemic phase is prevented by glucose injection little phosphopyruvate carboxylase activity appears in the liver, but galactose, mannose and fructose, which have no effect on the blood glucose concentration, also repress enzyme development. 5. Lactate, pyruvate and glycerol injections repress the premature development of phosphopyruvate carboxylase. 6. Injections of glucagon, adrenalin and noradrenalin into the rat foetus in utero result in development of phosphopyruvate carboxylase activity. 7. These findings are discussed in relation to the mechanism of initiation of enzyme synthesis in neonatal rat liver.

Electron microscopy and histochemistry of canalicular differentiation in fetal and neonatal rat liver

1972 ◽  
Vol 4 (3) ◽  
pp. 379-388 ◽  
Author(s):  
C. De Wolf-Pesters ◽  
R. De Vos ◽  
V. Desmet *
Keyword(s):  
Electron Microscopy ◽  
Rat Liver ◽  
Neonatal Rat

scholarly journals Mitochondriogenesis in the neonatal rat liver.

1987 ◽  
Vol 54 (4) ◽  
pp. 453-461
Author(s):  
Yuichiro Yoshida
Keyword(s):  
Rat Liver ◽  
Neonatal Rat

scholarly journals Factors that prevent the premature appearance of glucokinase in neonatal rat liver

1980 ◽  
Vol 186 (3) ◽  
pp. 817-826 ◽  
Author(s):  
M J O Wakelam ◽  
M B Allen ◽  
D G Walker
Keyword(s):  
Angiotensin Ii ◽  
Cyclic Amp ◽  
Insulin Release ◽  
Rat Liver ◽  
Neonatal Rat ◽  
Oral Glucose ◽  
Dibutyryl Cyclic Amp ◽  
Simultaneous Treatment ◽  
Physiological Factors ◽  
Glucose Administration

1. The physiological factors that prevent the precocious appearance of glucokinase activity in the 13-day-old rat that can be induced by oral glucose administration were explored. 2. Evidence is presented that the galactose component of milk sugar is inhibitory. In the absence of this inhibitory galactose, the amount of glucose necessary to effect appreciable induction is greater than that present in milk. 3. The induction is prevented both by administration of mannoheptulose, which inhibits insulin release, and by excess insulin; the amount of insulin available therefore seems to be critical. 4. The inhibition of induction by galactose does not appear to be via competition with glucose but by enhancing insulin release and thereby making this excessive. The relative amounts of glucose and insulin appear to be important in regulating glucokinase induction. 5. The precocious induction of glucokinase by glucose is inhibited by simultaneous treatment with approriate amounts of adrenaline, glucagon, dibutyryl cyclic AMP or isoprenaline but not by vasopressin or angiotensin II. 6. No single cause of glucokinase induction in neonatal rat liver can be recognized. The process is subject to regulation by many factors at a time subsequent to when competence to synthesize the enzyme has been established.

Differentially expressed transcripts in neoplastic hepatic nodules and neonatal rat liver studied by cDNA microarray analysis

2003 ◽  
Vol 104 (2) ◽  
pp. 131-138 ◽  
Author(s):  
�sa Tellgren ◽  
Timothy J.J. Wood ◽  
Amilcar Flores-Morales ◽  
Ulla-Britta Torndal ◽  
Lennart Eriksson ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Rat Liver ◽  
Cdna Microarray ◽  
Differentially Expressed ◽  
Neonatal Rat ◽  
Cdna Microarray Analysis

Toxic effect of chlorisondamine in neonatal rat liver

1982 ◽  
Vol 31 (9) ◽  
pp. 1798-1801 ◽  
Author(s):  
Cynthia M. Kuhn ◽  
Saul M. Schanberg
Keyword(s):  
Toxic Effect ◽  
Rat Liver ◽  
Neonatal Rat

scholarly journals Utilization of Dietary Amino Acids for Energy Production in Neonatal Rat Liver

1976 ◽  
Vol 10 (3) ◽  
pp. 158-164 ◽  
Author(s):  
Patricia Kreutler White ◽  
Sanford A Miller
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Energy Production ◽  
Neonatal Rat ◽  
Dietary Amino Acids
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