scholarly journals Another Approach to Assisted Ventilation in the Treatment of Hyaline Membrane Disease (HMD)

Neonatology ◽  
1970 ◽  
Vol 16 (1-3) ◽  
pp. 87-87
Author(s):  
H.S. Gruber ◽  
M.H. Klaus
Radiology ◽  
1973 ◽  
Vol 106 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Stuart S. Sagel ◽  
Penington Wimbush ◽  
David B. Goldenberg

1984 ◽  
Vol 12 (1) ◽  
pp. 41-45 ◽  
Author(s):  
P. D. Sly ◽  
J. H. Drew

A review of 9401 consecutive live births at the Mercy Maternity Hospital, Melbourne, was performed to determine the incidence of air leak in those with respiratory distress syndrome. Respiratory distress was detected in 552 (5.9%) infants and hyaline membrane disease was the most common cause occurring in 238 (2.5%) infants. Air leak developed in 22% of infants with respiratory distress, 8% had pulmonary interstitial emphysema alone, 14% had pneumomediastinum or pneumothorax and 7% had emphysema with pneumomediastinum or pneumothorax. Mortality increased from 12% in infants without air leak to 31% (p < 0.001) in infants with air leak. Ninety-five per cent of air leak developed in infants with hyaline membrane, and these were smaller, less mature and sicker than those without air leak. Eighty-seven per cent of air leak developed in infants treated with assisted ventilation and was commoner with mechanical ventilators with a more rapid rise in inspiratory pressure.


1970 ◽  
Vol 76 (2) ◽  
pp. 174-182 ◽  
Author(s):  
Mildred T. Stahlman ◽  
Atties F. Malan ◽  
Frank M. Shepard ◽  
Willard J. Blankenship ◽  
William C. Young ◽  
...  

1964 ◽  
Vol 39 (207) ◽  
pp. 481-484 ◽  
Author(s):  
M. Delivoria-Papadopoulos ◽  
P. R. Swyer

1978 ◽  
Vol 53 (11) ◽  
pp. 878-881 ◽  
Author(s):  
F P Manginello ◽  
A E Grassi ◽  
S Schechner ◽  
A N Krauss ◽  
P A Auld

Two methods of providing assisted ventilation were compared in infants severely ill with hyaline membrane disease (HMD). 10 infants were assigned to each group. One group received ventilation with a volume-cycled respirator, and the other was ventilated using a pressure-limited ventilator and reversed I:E ratio. Both groups were well matched for severity of illness in terms of pH and blood gases. pH and PO2 were quickly corrected by both ventilators. However, the pressure-cycled ventilator group had higher survival and lower complication rates. PAO2 after one hour was substantially improved at the same FIO2 in the pressure-limited group and after 8 hours the FIO2 required to maintain a PaO2 of 50--70 mmHg (6.6--9.3 kPa) was significantly decreased compared with the volume-cycled group. No effects on blood pressure were detected in either group. The study shows that the pressure-limited method is significantly better.


PEDIATRICS ◽  
1970 ◽  
Vol 46 (1) ◽  
pp. 117-119
Author(s):  
Jean-Marie Matthieu ◽  
Daniel Nussle ◽  
Antonio Torrado ◽  
Hossein Sadeghi

Pneumopericardium complicating the course of hyaline membrane disease in a newborn, premature infant is reported. The details of other instances of neonatal pneumopericardium although unassociated with hyaline membrane disease are reviewed. The clinical manifestations, similar to those of pneumomediastinum, appear very suddenly and can lead to cardiac tamponade. Most cases described in the newborn infant are a complication of assisted ventilation by intermittent positive pressure. The chest x-ray characteristically shows a zone of diminished density surrounding the cardiac silhouette. The prognosis is bad unless emergency treatment (puncture and aspiration) is promptly performed.


PEDIATRICS ◽  
1983 ◽  
Vol 71 (4) ◽  
pp. 588-593
Author(s):  
Richard L. Naeye ◽  
M. Jeffrey Maisels ◽  
Robert P. Lorenz ◽  
John J. Botti

A study was undertaken to determine why there is such variability in morbidity and mortality in neonates exposed to antenatal chorioamnionitis. Villous edema provides a clue. It was present in 72/83 placentas with chorioamnionitis. The extent and severity of the edema had a strong, positive correlation with cord arterial blood pH values, low Apgar scores, the need to resuscitate vigorously at birth, the subsequent need for assisted ventilation, the frequency of hyaline membrane disease, and neonatal mortality. Most of the difference in morbidity and mortality between preterm and full-term infants was related to the greater severity and extent of villous edema in those born prematurely.


2021 ◽  
pp. 26-27
Author(s):  
Rakesh Kumar

Background & Objective: Mechanical ventilation is the standard treatment for hyaline membrane disease (HMD) and has increased neonatal survival. However this increased survival has come at the expense of increased morbidity in the form of chronic lung disease, longer duration of hospitals stay and at the cost of expensive technology. Alternate form of respiratory support is early nasal CPAP. Hence present study aims at managing increasing number of preterm babies with HMD with a non-invasive approach in the form of early nasal CPAP. Methods: 50 babies of 28-34 weeks gestational age admitted in neonatal ICU of pediatrics Department at Patna Medical collage & hospital, Patna with clinical diagnosis of HMD, requiring respiratory support were treated with early nasal CPAP and studied prospectively from 01.12.2019 to 30.11.2020. Chi-square and other appropriate tests. We found a succ Statistical analysis: Results: ess rate of 80% in babies with HMD, who were managed with early nasal CPAP alone. Remaining 20% needed intubation and higher mode of ventilation. Mild and moderate grade HMD were effectively managed with early nasal CPAP (P<0.05). It was also found to be effective in babies of mothers who have received antenatal steroids (P<0.05). Prematurity is the commonest predi Conclusion: sposing cause for HMD. Early nasal CPAP is safe, inexpensive and effective means of respiratory support in HMD. it is useful in mild and moderate grade disease. It may not be a replacement for assisted ventilation in severe disease. It is also found to be effective in babies of mothers who have received antenatal steroids


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