Hydrogen Peroxide Generation in the Erythrocytes of Newborn Infants

Neonatology ◽  
1970 ◽  
Vol 15 (3-4) ◽  
pp. 135-141 ◽  
Author(s):  
R. Bracci ◽  
P.A. Benedetti ◽  
V. Ciambellotti
Keyword(s):  
Hydrogen Peroxide ◽  
Newborn Infants ◽  
Hydrogen Peroxide Generation ◽  
Erythrocytes Of Newborn Infants

Hydrogen Peroxide Generation with 100% Faradaic Efficiency on Metal-Free Carbon Black

ACS Catalysis ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2454-2459
Author(s):  
Zhe Wang ◽  
Qin-Kun Li ◽  
Chenhao Zhang ◽  
Zhihua Cheng ◽  
Weiyin Chen ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Carbon Black ◽  
Free Carbon ◽  
Faradaic Efficiency ◽  
Metal Free ◽  
Hydrogen Peroxide Generation

scholarly journals Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration

Redox Biology ◽  
2021 ◽  
Vol 43 ◽  
pp. 101980
Author(s):  
Andree G. Pearson ◽  
Juliet M. Pullar ◽  
John Cook ◽  
Emma S. Spencer ◽  
Margreet CM. Vissers ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Vitamin C ◽  
High Dose ◽  
Peroxiredoxin 2 ◽  
Hydrogen Peroxide Generation ◽  
High Dose Vitamin

scholarly journals Hydrogen Peroxide Generation Induces pp60srcActivation in Human Platelets

2003 ◽  
Vol 279 (3) ◽  
pp. 1665-1675 ◽  
Author(s):  
Juan A. Rosado ◽  
Pedro C. Redondo ◽  
Ginés M. Salido ◽  
Emilio Gómez-Arteta ◽  
Stewart O. Sage ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Human Platelets ◽  
Hydrogen Peroxide Generation

Hydrogen Peroxide Generation by Eosinophils in Allergic Rhinitis

1991 ◽  
Vol 18 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Hiroshi Ogasawara ◽  
Shiro Yoshimura ◽  
Takeo Kumoi
Keyword(s):  
Hydrogen Peroxide ◽  
Allergic Rhinitis ◽  
Hydrogen Peroxide Generation

RED CELL METABOLISM IN THE NEWBORN INFANT. IV. TRANSMEMBRANE POTASSIUM FLUX

PEDIATRICS ◽  
1969 ◽  
Vol 43 (3) ◽  
pp. 396-401
Author(s):  
Stuart F. Blum ◽  
Frank A. Oski
Keyword(s):  
Membrane Permeability ◽  
Cell Metabolism ◽  
Newborn Infants ◽  
Red Cell ◽  
Membrane Injury ◽  
Red Cell Metabolism ◽  
Potassium Flux ◽  
Potassium Influx ◽  
Normal Adults ◽  
Erythrocytes Of Newborn Infants

Measurements of transmembrane potassium flux in the erythrocytes of newborn infants and normal adults demonstrated an increased net loss of potassium in the infants. This loss appeared to be a consequence of decreased active potassium influx rather than an increased membrane permeability. These studies suggest that the erythrocytes of newborn infants may be more vulnerable to destruction resulting from membrane injury because of their reduced capacity for active transport.

PHYSIOLOGIC HYPERBILIRUBINEMIA AND HEMOLYSIS OF ERYTHROCYTES BY HYDROGEN PEROXIDE SOLUTION IN THE NEWBORN: INVESTIGATION OF A POSSIBLE RELATIONSHIP

PEDIATRICS ◽  
1957 ◽  
Vol 20 (1) ◽  
pp. 92-97
Author(s):  
Jo-Anne E. Richards ◽  
Richard B. Goldbloom ◽  
Ronald L. Denton
Keyword(s):  
Hydrogen Peroxide ◽  
Statistical Analysis ◽  
Vitamin E ◽  
Clinical Significance ◽  
Newborn Infant ◽  
Newborn Infants ◽  
Control Group ◽  
Term Infants ◽  
Mean Values ◽  
Relative Deficiency

Forty-three full-term infants have been studied with respect to hemolysis of erythrocytes in solutions of hydrogen peroxide and concentrations of bilirubin in the serum. Mean values for concentration of bilirubin in the serum and percentage of hemolysis followed similar patterns in the first few days of life. However, statistical analysis of the data in individual cases showed no significant correlation between the degree of hemolysis in solutions of hydrogen peroxide and the concentrations of bilirubin in the serum. Administration of vitamin E prevented an increase in hemolysis of erythrocytes in solutions of hydrogen peroxide but failed to produce any significant change in concentrations of bilirubin as compared with the control group. The evidence suggests that the relative deficiency of vitamin E which exists in most newborn infants does not play a part in the causation or maintenance of physiologic hyperbilirubinemia. The clinical significance of increased hemolysis of the erythrocytes of the newborn infant in solutions of hydrogen peroxide remains a mystery. Possible approaches to the clarification of this problem are suggested.

scholarly journals Multienzymatic in situ hydrogen peroxide generation cascade for peroxygenase-catalysed oxyfunctionalisation reactions

2019 ◽  
Vol 74 (3-4) ◽  
pp. 101-104 ◽  
Author(s):  
Milja Pesic ◽  
Sébastien Jean-Paul Willot ◽  
Elena Fernández-Fueyo ◽  
Florian Tieves ◽  
Miguel Alcalde ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Formate Dehydrogenase ◽  
Flavin Mononucleotide ◽  
Candida Boidinii ◽  
Reaction Parameters ◽  
Old Yellow Enzyme ◽  
Hydroxylation Reaction ◽  
In Situ Generation ◽  
Hydrogen Peroxide Generation

Abstract There is an increasing interest in the application of peroxygenases in biocatalysis, because of their ability to catalyse the oxyfunctionalisation reaction in a stereoselective fashion and with high catalytic efficiencies, while using hydrogen peroxide or organic peroxides as oxidant. However, enzymes belonging to this class exhibit a very low stability in the presence of peroxides. With the aim of bypassing this fast and irreversible inactivation, we study the use of a gradual supply of hydrogen peroxide to maintain its concentration at stoichiometric levels. In this contribution, we report a multienzymatic cascade for in situ generation of hydrogen peroxide. In the first step, in the presence of NAD+ cofactor, formate dehydrogenase from Candida boidinii (FDH) catalysed the oxidation of formate yielding CO2. Reduced NADH was reoxidised by the reduction of the flavin mononucleotide cofactor bound to an old yellow enzyme homologue from Bacillus subtilis (YqjM), which subsequently reacts with molecular oxygen yielding hydrogen peroxide. Finally, this system was coupled to the hydroxylation of ethylbenzene reaction catalysed by an evolved peroxygenase from Agrocybe aegerita (rAaeUPO). Additionally, we studied the influence of different reaction parameters on the performance of the cascade with the aim of improving the turnover of the hydroxylation reaction.

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