Postnatal Changes in the Blood Serum Content of Glycerol and Free Fatty Acids in Premature Infants

Neonatology ◽  
1967 ◽  
Vol 11 (1-2) ◽  
pp. 50-60 ◽  
Author(s):  
V. Melichar ◽  
H. Wolf
Keyword(s):  
Fatty Acids ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Premature Infants

scholarly journals The effect of oil phytopreparations on the lipid status in an experiment

2012 ◽  
Vol 93 (4) ◽  
pp. 561-563
Author(s):  
A K Berdgaleeva ◽  
N T Aldiyarova ◽  
S K Sakhanova
Keyword(s):  
Fatty Acids ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Phospholipid Content ◽  
Low Density ◽  
Cholesterol Diet ◽  
Lipid Status ◽  
Oil Extract

Aim. To study the effect of oil extracts of the burdock root and elecampane on the lipid profile in an experimental model of cholesterolosis. Methods. Experiments were performed on 60 white nonlinear rats, weighing 180-300 g. The oil extract from the burdock root was administered intragastrically at a dose of 2.5 ml/kg, and an extract from the root of elecampane - at a dose of 1.0 ml/kg during the last 30 days on the background of a cholesterol diet. After removal of the animals from the experiment the levels of cholesterol, triglycerides, high and low density lipoproteins, phospholipids, free fatty acids were determined in the blood serum and in liver homogenates with the use of standardized sets. Results. Administration of oil extracts of the burdock root and elecampane on the background of a cholesterol diet resulted in a significant reduction in serum cholesterol level by average of 1.48 times, triglycerides level - by 1.9 times, low-density lipoproteins level - by 1.8 times, as well as in a significant increase in the level of high-density lipoproteins on average by 1.5 times compared with the pathology model. In the same conditions the oil extracts of the burdock root and elecampane significantly increased the phospholipid content in the liver tissue by 1.4 and 1.7 times, respectively, the content of free fatty acids - by 2 times in average, the content of esterified cholesterol - by about 1.5 times as compared with the pathology model. Conclusion. The studied oils have a unidirectional positive effect on the lipid content in blood serum and liver in an experimental cholesterolosis; the oil extract from the root of elecampane has a more pronounced effect.

scholarly journals EFFECTS OF GROSSHEMIN AND GROSSMISIN ON THE ACUTE HYPERLIPIDEMIA MODEL INDUCED BY ETHANOL

2014 ◽  
Vol 13 (1) ◽  
pp. 67-72 ◽  
Author(s):  
A. V. Ratkin ◽  
O. A. Kaidash ◽  
V. V. Ivanov ◽  
A. I. Vengerovsky ◽  
S. M. Adekenov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Total Cholesterol ◽  
Sesquiterpene Lactones ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density

Objective: study sesquiterpene lactones grosshemin and grossmisin lipid-lowering properties on the model of acute hyperlipidemia induced by ethanol in rats.Materials and methods. Rats during 7 days injected into the stomach grosshemin and grossmisin in a dose 10 mg/kg or reference drug nicotinic acid in a dose 25 mg/kg. Hyperlipidemia caused by single introduction of ethanol into the stomach in a dose 5 g/kg. In blood serum of tail vein measured the triacylglycerols, total cholesterol, high density and low density lipoproteins cholesterol, also the level of free fatty acids. Calculated the ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol and the index of atherogenicity.Results. A single dose of ethanol increased serum level of triacylglycerols in 1.9 times, free fatty acids – in 3.2 times, low density lipoproteins – on 44% in comparison with the intact animals indices. It shows the development of acute hyperlipidemia. Serum total cholesterol, high density lipoproteins cholesterol and the index of atherogenicity were not changed. Course sesquiterpene lactones grosshemin and grossmisin introduction against the background of acute hyperlipidemia was accompanied by a decrease in the serum of triacylglycerols levels respectively by 19.8% and 34.1%. Nicotinic acid lowered the content of triacylglycerols by 42.4%. Grosshemin and nicotinic acid reduced the increased level of free fatty acids in the blood serum by 60.7–67.9%. Grossmisin and nicotinic acid decreased by 14.6–17.2% of total cholesterol in the blood serum. In acute hyperlipidemia grosshemin and grossmisin reduced low density lipoproteins cholesterol by 17.6% and 20%, respectively, nicotinic acid – by 15.7%. Both of sesquiterpene lactone and nicotinic acid did not modify the content of high density lipoproteins cholesterol. When introduction grosshemin, grossmisin and nicotinic acid ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol significantly increased by 42.8%, 38,6% and 22.1% respectively.Conclusion. Sesquiterpene lactones grosshemin and grossmisin posses hypolipidemic effect in acute experimental hyperlipidemia caused by the ethanol introduction. Lactones normalize many indices of lipid metabolism, which can be caused by different biochemical targets of these molecules. Lactones, as nicotinic acid, in the model of acute hyperlipidemia decrease in blood serum triacylglycerols, total cholesterol, and low density lipoproteins cholesterol content. Grosshemin and nicotinic acid also reduce the free fatty acids level.

scholarly journals Blood concentrations of thyroid hormones and lipids and histological changes in the liver in dairy cows in post-parturient period

2009 ◽  
Vol 63 (5-6) ◽  
pp. 285-297
Author(s):  
Radojica Djokovic
Keyword(s):  
Fatty Acids ◽  
Thyroid Hormones ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Histological Changes ◽  
Blood Concentrations ◽  
Thyroidal Status ◽  
Biochemical Examination

The triiodthyronine (T3), thyroxine (T4), glucose, free fatty acids (FFA), triacylglycerols (TAG) and total cholesterol concentrations were estimated in the blood serum and content of lipids in the liver in healthy (n=10) and ketotic (n=10) dairy cows in the post parturient period. Samples of liver and blood tissues were taken from all the cows. Pathohistoligical examination of liver tissues showed statistically significant higher (p<0.01) lipid infiltration in ketotic cows compared to healthy ones. Biochemical examination of blood serum showed significantly higher values (p<0.01) of free fatty acids in ketotic cows such as significantly lower concentrations of glucose (p<0.01), triacylglycerols (p<0.01), total cholesterol (p<0.05), triiodthyronine (p<0.05) and thyroxine (p<0.05) compared to values of these parameters in the blood serum in healthy cows. Significant increase of concentration of free fatty acids, such as positive correlation (r=0.51; p<0.05) between the free fatty acids in blood and the content of lipids in liver in ketotic cows compared to healthy ones, as well as pathohistological report, shows that during intensive lipomobilisation newly synthesized triacylglycerols accumulated in the hepatocytes. In ketotic cows hypo thyroidal status is established and it can be a significant factor in the development of fatty liver. .

scholarly journals INDICES OF FATTY ACIDS SPECTRUM OF LIPIDS IN THE BLOOD SERUM OF STERLET OF DIFFERENT AGE

2018 ◽  
Vol 2 ◽  
pp. 3-8 ◽  
Author(s):  
Roza Suleimanova ◽  
Dmytro Melnychuk ◽  
Liliia Kalachniuk
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Acid Composition ◽  
Moderate Increase ◽  
National Academy Of Sciences ◽  
Fa Composition ◽  
Lipid Fractions

As the only sturgeon living in freshwater, sterlet is important for breeding in industrial fish farms, where lately cases of early mortality of this species have been detected. Hence, in order to preserve the species, it is important to study the parameters of fatty acid (FA) composition of lipid fractions of the blood serum of sterlet. Here we present changes of fatty acid composition in different lipid fractions of the blood serum of sterlets of different age (namely two-, three- and nine-year-old) with the masses 0.3–0.4, 0.5–0.6 and 5–6 kgfor the age-groups of fish, respectively. Fatty acid (FA) composition was determined using gas-chromatography on HRGC 5300 (Italy) in Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU). Fatty acid composition of starlet blood serum is presented by saturated and unsaturated high-molecular weight carboxylic acids, mostly palmic, stearic, oleic and linoleic. In the phospholipids fraction, there was a moderate increase in saturated and monounsaturated fatty acids and a slight decrease in polyunsaturated fatty acids depending on the age of fish. As for free fatty acids, there was a drop in the saturated ones depending on the starlet age. Among the free fatty acids of sterlet blood serum, we identified 28 acids, of them 39 %, 35 % and 30 % were saturated in 2-, 3-year-old and mature fish, respectively. Monounsaturated FA content was 14 %, 23 % and 23 % in 2-, 3-year-old and adult sterlet fish, and polyunsaturated FA content –46 %, 41 % and 36 %, respectively. The data can be used for the theoretical verification of correcting supplementary feed and premixes.

Lipid release by liver slices

1961 ◽  
Vol 201 (6) ◽  
pp. 1030-1034 ◽  
Author(s):  
Margit Hamosh ◽  
B. Shapiro
Keyword(s):  
Fatty Acids ◽  
Serum Albumin ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Intravenous Injection ◽  
Salt Solutions ◽  
Protein Solution ◽  
Relative Contribution ◽  
Liver Slices ◽  
Fat Fraction

Slices were prepared from livers of rats which had received an intravenous injection of 1-C14-palmitate 20 min prior to the removal of the livers. The labeled acids were found predominantly in the neutral fat fraction (61%), smaller amounts (32%) in the phospholipids, and only 6% as unesterified fatty acids. When such slices were incubated in salt solutions, labeled lipids were released into the medium. This release could be promoted by the use of blood serum as medium or by the addition of α- or ß-lipoproteins to the salt solutions. Serum albumin was less effective. Release came rapidly to an end when an equilibrium was established between the liver and the medium and could be renewed by replacing the medium with a fresh protein solution. When unlabeled liver slices were incubated in media with labeled triglycerides, the labeled compound was assimilated by the liver. The presence of blood serum and lipoproteins increased the relative contribution of the phospholipids to the lipids released. Serum albumin and blood serum promoted the release of free fatty acids by the liver. The physiological significance of this latter process is discussed.

scholarly journals Blood Concentrations of Thyroid Hormones and Lipids and Content of Lipids in the Liver of Dairy Cows in Transitional Period

2007 ◽  
Vol 76 (4) ◽  
pp. 525-532 ◽  
Author(s):  
R. Djoković ◽  
H. Šamanc ◽  
M. Jovanović ◽  
Z. Nikolić
Keyword(s):  
Fatty Acids ◽  
Thyroid Hormones ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Clinical Symptoms ◽  
Liver Steatosis ◽  
Transitional Period ◽  
Blood Concentrations

The aim of the present investigation was to determine the correlation in the blood concentrations of thyroid hormones, lipids and glucose as well as the content of lipids in the liver of dairy cows in the transitional period. The animals (n = 40) were divided into four groups: the first group included late pregnant cows (n = 10) from the 10th to 4th day before calving; the second group included late pregnant cows (n = 10) from the 4th to 1st day before calving; the third group included clinically puerperal healthy cows (n = 10), whereas the fourth group included puerperal cows with clinical symptoms of ketosis (n = 10). Samples of liver and blood tissues were taken from all cows. Pathohistological examination of liver samples showed statistically significantly higher (p < 0.01) lipid infiltration in ketotic cows compared to healthy cows in late pregnancy and puerperium. Biochemical examination of blood serum showed significantly higher values (p < 0.01) of free fatty acids in ketotic cows, such as significantly lower blood concentrations of glucose (p < 0.01), triacylglycerols (p < 0.01), total cholesterol (p < 0.05), triiodthyronine (p < 0.05) and thyroxine (p < 0.05), compared to the values obtained in the blood serum in the groups of healthy cows before and after calving. In this study, significantly positive correlations were determined between the content of lipids in the liver and blood concentration of free fatty acids (r = 0.51; p < 0.05) as well as the negative ones between the content of lipids in the liver and blood concentrations of glucose (r = -0.69; p < 0.05), triacylglycerols (r = -0.55; p < 0.05) and total cholesterol (r = -0.50; p < 0.05) in the group of ketotic cows. Our investigations suggested that a hypothyroidal status was established in ketotic cows and that the blood concentrations of free fatty acids, triacylglycerols, total cholesterol and glucose served as major biochemical indicators in determining liver steatosis in the dairy cows in the transitional period.

scholarly journals Changes in the Spectrum of Free Fatty Acids in Blood Serum of Dairy Cows during a Prolonged Summer Heat Wave

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3391
Author(s):  
Roman Mylostyvyi ◽  
Veerasamy Sejian ◽  
Olena Izhboldina ◽  
Olena Kalinichenko ◽  
Lina Karlova ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Dairy Cows ◽  
Heat Wave ◽  
Negative Energy ◽  
Control Group ◽  
Fa Composition ◽  
Humidity Index

This experiment was conducted to study the effect of a prolonged hot period on the fatty acid (FA) composition in blood serum of dairy cows. Eighteen multiparous Holstein cows were randomly assigned to the hyperthermia group (HYP, n = 8) in August (summer season) and the control group (CON, n = 10) in October (autumn season). Blood from animals of the HYP group was collected in one heat wave, which was preceded by a long period of heat stress (HS, temperature-humidity index (THI ≥ 72)). Blood from cows of the CON group was collected under thermal comfort conditions (THI < 68). The spectrum of free fatty acids (FFA) in the blood serum was analyzed by gas chromatography. The concentration of FFA increased, including saturated FAs and monounsaturated FAs, in the blood serum of cows under conditions of prolonged HS. This was associated with the mobilization of FA into the bloodstream from adipose tissue, as a consequence of negative energy balance. An increase in the ratio of n-6/n-3 polyunsaturated FAs may indicate biomembrane dysfunction and adversely affect dairy cows. This study showed that prolonged periods of heat can affect the FA composition of blood. How much this leads to changes in the FA composition of milk and the quality of food products remains to be seen in further research.

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