In vitro Activity of Sparfloxacin (CI-978), a New Broad-Spectrum Fluoroquinolone

Chemotherapy ◽  
1992 ◽  
Vol 38 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Hussain Qadri ◽  
Yoshio Ueno ◽  
Joyce Burns ◽  
Edna Almodovar ◽  
Nada Rabea
Keyword(s):  
Broad Spectrum ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci

2007 ◽  
Vol 52 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Catherine Clark ◽  
Kathy Smith ◽  
Lois Ednie ◽  
Tatiana Bogdanovich ◽  
Bonifacio Dewasse ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
The Other ◽  
Quinolone Resistance ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Resistance Selection ◽  
Resistant Strains

ABSTRACT DC-159a yielded MICs of ≤1 μg/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci (resistance was defined as a levofloxacin MIC ≥4 μg/ml). Although the MICs for DC-159a against quinolone-susceptible pneumococci were a few dilutions higher than those of gemifloxacin, the MICs of these two compounds against 28 quinolone-resistant pneumococci were identical. The DC-159a MICs against quinolone-resistant strains did not appear to depend on the number or the type of mutations in the quinolone resistance-determining region. DC-159a, as well as the other quinolones tested, was bactericidal after 24 h at 2× MIC against 11 of 12 strains tested. Two of the strains were additionally tested at 1 and 2 h, and DC-159a at 4× MIC showed significant killing as early as 2 h. Multistep resistance selection studies showed that even after 50 consecutive subcultures of 10 strains in the presence of sub-MICs, DC-159a produced only two mutants with maximum MICs of 1 μg/ml.

scholarly journals In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

1992 ◽  
Vol 36 (1) ◽  
pp. 100-107 ◽  
Author(s):  
K Andries ◽  
B Dewindt ◽  
J Snoeks ◽  
R Willebrords ◽  
K van Eemeren ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Vitro Activity ◽  
In Vitro Activity
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